- Volume 16 Issue 17
DOI QR Code
Serum Beta-2 Microglobulin: a Possible Marker for Disease Progression in Egyptian Patients with Chronic HCV Related Liver Diseases
- Ouda, SM (Department of Microbiology & Immunology, Faculty of Medicine, Cairo University) ;
- Khairy, AM (Department of Endemic Medicine, Faculty of Medicine, Cairo University) ;
- Sorour, Ashraf E (Department of Microbiology & Immunology, Faculty of Medicine, Cairo University) ;
- Mikhail, Mikhail Nasr (Department of Microbiology & Immunology, Faculty of Medicine, Cairo University)
- Published : 2015.12.03
Background: Egypt has the highest prevalence of HCV infection in the world (~14.7%). Around 10-15% of HCV-infected persons will advance to cirrhosis within the first 20 years. The incidence of HCC is expected to grow in the next two decades, largely due to HCV related cirrhosis, and detection of HCC at an early stage is critical for a favorable clinical outcome. No simple reliable non-invasive marker has been available till now. B2M, a non-glycosylated polypeptide composed of 99 amino acids, is one of the components of HLA class I molecules on the surfaces of all nucleated cells. It has been reported that the level of serum B2M is elevated in patients with chronic hepatitis C and HCV-related HCC when compared to HCV-negative patients or healthy donors. Determining the clinical utility of serum B2M as a marker for disease progression in Egyptian patients with HCV related chronic hepatitis, cirrhosis and hepatocellular carcinoma was the aim of the present study. Materials and Methods: In this analytical cross sectional study 92 participants were included in 4 equal groups: Group (1) non cirrhotic chronic HCV; Group (2) HCV related liver cirrhosis; Group (3) HCC on top of HCV,; and Group (4) healthy controls. History taking, clinical examination, routine labs and abdominal ultrasound were conducted for all patients, PCR and Metavir scores for group (1) patients, and triphasic CT abdomen and AFP for Group (3) patients. B2M levels were measured in serum with a fully-automated IMX system. Results: The mean serum B2M level of Group (1) was
- Agha S, Tanaka Y, Saudy N, et al (2004). Reliability of hepatitis C virus core antigen assay for detection of viremia in HCV genotypes 1, 2, 3, and 4 infected blood donors: a collaborative study between Japan, Egypt, and Uzbekistan. J Med Virol, 73, 216-22. https://doi.org/10.1002/jmv.20078
- Ancha Baranova, Priyanka Lal, Aybike Birerdinc, Zobair M Younossi (2011). Non-Invasive markers for hepatic fibrosis. Gastroenterol, 11, 91.
- Asanza Cilia G, Carmelo Garcia A-Monezo, Gerardo Clement, et al (1997). Immunohistochemical evidence of immunopathogenetic mechanisms in Chronic Hepatitis C Recurrence After Liver Transplantation. Hepatol, 26, 755-63. https://doi.org/10.1002/hep.510260331
- Behne Tara and Sitki M. Copur (2012). Biomarkers for Hepatocellular Carcinoma. Int J Hepatol, 859076.
Changhoon Yoo, Dok Hyun Yoon, Shinkyo Yoon, et al (2015). Prognostic impact of
$\beta$2-microglobulin in patients with non-gastric mucosa-associated lymphoid tissue lymphoma. Leukaemia Lymphoma, 56, 688-93. https://doi.org/10.3109/10428194.2014.917640
- Chatterjeea Reshmi and Mitra Abhisek (2015). An overview of effective therapies and recent advances in biomarkers for chronic liver diseases and associated liver cancer. Int Immunopharmacol, 24, 335-45. https://doi.org/10.1016/j.intimp.2014.12.024
- Chung Raymond T., and Baumert F (2014). Curing chronic hepatitis c. the arc of a medical triumph. N Engl J Med, 370, 1576-8. https://doi.org/10.1056/NEJMp1400986
- Cuadros Diego F, Branscum Adam J, Miller F. DeWolfe, Abu- Raddad Laith J (2014). Spatial epidemiology of hepatitis C virus infection in Egypt: Analyses and implications. Hepatol, 60, 1150-9. https://doi.org/10.1002/hep.27248
- ELGendy Saad M, Mohamed Hessien, Mahmoud M. EL Sherbiny (2005). A panel of molecular markers in hepatitis c virus-related hepatocellular carcinoma. J Egyptian Nat Cancer Inst, 17, 270-8.
- Feld Jordan J, Kowdley Kris V, Coakley Eoin, et al (2014). Treatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavirin. N Engl J Med, 370, 1594-603. https://doi.org/10.1056/NEJMoa1315722
- Flemming Jennifer A, Ju Dong Yang, Eric Vittinghoff, W. Ray Kim, Norah A (2014). Risk prediction of hepatocellular carcinoma in patients with cirrhosis: The Adress HCC risk model. Terrault Cancer, 120, 3485-93. https://doi.org/10.1002/cncr.28832
- Hajarizadeh Behzad, Jason Grebely, Gregory J. Dore (2013). Epidemiology and natural history of HCV infection. Nature Rev Gastroenterol Hepatol, 10, 553-62. https://doi.org/10.1038/nrgastro.2013.107
- Hamidreza Abdolsamadi, Peiman Eini , Kieslichova E, et al. (2013). Evaluation of salivary beta-2 microglobulin as HBV proliferation marker in HBS Ag+, HBV DNA PCR+ and HBV DNA PCR- subjects. J Gastroenterol Hepatol, 6, 105-11.
- Huang J (2002). HLA in hepatocellular carcinoma. World J Gastroenterol, 8, 1007-9327.
- Huckans Marilyn, Bret E. Fuller, Hannah Olavarria, et al (2014). Altered expression of peripheral immune factors is associated with neuro-psychiatric symptom severity in adults with and without chronic hepatitis C virus infection. Brain Behavior, 4, 123-42. https://doi.org/10.1002/brb3.200
- Kanwal Fasiha, Bacon Bruce R (2012). Does treatment alter the natural history of chronic HCV? Chronic Hepatitis C Virus, 103-12.
- Khalid SS, Hamid S, Siddiqui AA, Qureshi A, Qureshi N (2011). Gene profiling of early and advanced liver disease in chronic hepatitis C patient. J Hepatol Int, 5, 782-8. https://doi.org/10.1007/s12072-011-9252-4
- Kim JW, Wang XW (2003). Gene expression profiling of preneoplastic liver diseases and liver cancer. A new era for early detection and treatment of these deadly diseases. Carcinogenesis, 24, 363-9. https://doi.org/10.1093/carcin/24.3.363
- Malaguarnera M, Di Fazio I, Ferlito L (2000). Increase of serum beta 2-microglobulin in patients affected by HCV correlated hepatocellular carcinoma. Eur J Gastroenterol Hepatol, 12, 937-9. https://doi.org/10.1097/00042737-200012080-00014
- Migliaresia Sergio, Alessandro Bresciania, Luci Ambrosone, et al (2000). Increased serum concentrations of soluble HLA-class I antigens in hepatitis C virus related mixed cryoglobulinaemia. Ann Rheum Dis, 59, 20-5. https://doi.org/10.1136/ard.59.1.20
- Mourad Wesam, Basuni Ashraf, Fouad Tarekb, et al (2013). The value of PIVKA-II and AFP-L3% in the diagnosis of hepatocellular carcinoma with normal and abnormal AFP levels. Egypt Liver J, 3, 1-5. https://doi.org/10.1097/01.ELX.0000424246.18235.c5
- Quiroga J, Martin J, Pardo M, Carreno V (1994). Serum levels of soluble immune factors and pathogenesis of chronic hepatitis C, and their relation to therapeutic response to interferonalpha. Dig Dis Sci, 39, 2485-96 https://doi.org/10.1007/BF02087671
- Riolobos Laura, Hirata Roli K, Turtle Cameron J, et al (2013). HLA engineering of human pluripotent stem cells. Molecular Therapy, 21, 1232-41. https://doi.org/10.1038/mt.2013.59
Saito Yumi , Nobukui Oba, Syuta Nishinakagawa, et al (2010). Identification of
$\beta$2-microgloblin as a candidate for early diagnosis of imaging-invisible hepatocellular carcinoma in patient with liver cirrhosis. Oncol Reports, 23, 1325-30.
- Saleh M (2012). Study the expression level of beta 2 microglobulin gene on hepatitis C patients before and after treatment with Interferon. Baghdad Sci J, 9, 504-10.
- Tabayoyong William B. and Zavazava Nicholas (2007). Soluble HLA revisited. Leuk Res, 31, 121-5. https://doi.org/10.1016/j.leukres.2006.06.008
- Ward DG, Cheng Y, N'Kontchou G, et al (2006). Preclinical and post-treatment changes in the HCC-associated serum proteome. British J Cancer, 95, 1379-83. https://doi.org/10.1038/sj.bjc.6603429
- A noninvasive diagnosis of hepatic fibrosis by BioFibroScore® in chronic hepatitis C patients vol.33, pp.1, 2017, https://doi.org/10.1111/jgh.13834
- How best to estimate glomerular filtration rate? Novel filtration markers and their application pp.1062-4821, 2018, https://doi.org/10.1097/MNH.0000000000000444
- Does hepatic impairment influence renal function parameters in liver cirrhosis? vol.6, pp.2, 2018, https://doi.org/10.2478/jtim-2018-0017