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Family History of Cancer and Head and Neck Cancer Risk in a Chinese Population

  • Huang, Yu-Hui Jenny (Division of Public Health, Department of Family and Preventive Medicine, and Huntsman Cancer Institute, University of Utah School of Medicine) ;
  • Lee, Yuan-Chin Amy (Division of Public Health, Department of Family and Preventive Medicine, and Huntsman Cancer Institute, University of Utah School of Medicine) ;
  • Li, Qian (Department of Preventive Medicine: Icahn School of Medicine at Mount Sinai) ;
  • Chen, Chien-Jen (Genomics Research Center, Academia Sinica) ;
  • Hsu, Wan-Lun (Genomics Research Center, Academia Sinica) ;
  • Lou, Pen-Jen (Graduate Institute of Epidemiology and Preventive Medicine, National Taiwan University) ;
  • Zhu, Cairong (Department of Otolaryngology, National Taiwan University Hospital) ;
  • Pan, Jian (Department of Epidemiology and Biostatistics, West China School of Public Health, Sichuan University) ;
  • Shen, Hongbing (Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University) ;
  • Ma, Hongxia (Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University) ;
  • Cai, Lin (Department of Epidemiology and Biostatistics, School of Public Health, Fujian Medical University) ;
  • He, Baochang (Department of Epidemiology and Biostatistics, School of Public Health, Fujian Medical University) ;
  • Wang, Yu (Department of Head and Neck Surgery, Fudan University) ;
  • Zhou, Xiaoyan (Department of Pathology, Fudan university Shanghai Cancer Center, Shanghai, China Department of Oncology, Shanghai Medical College, Fudan University) ;
  • Ji, Qinghai (Department of Head and Neck Surgery, Fudan University) ;
  • Zhou, Baosen (School of Public Health, China Medical University) ;
  • Wu, Wei (School of Public Health, China Medical University) ;
  • Ma, Jie (Department of Head & Neck Oncology, Henan Cancer Hospital) ;
  • Boffetta, Paolo (Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai) ;
  • Zhang, Zuo-Feng (Department of Epidemiology and Center for Environmental Genomics, UCLA Fielding School of Public Health) ;
  • Dai, Min (National Office of Cancer Prevention & Control Cancer Institute & Hospital) ;
  • Hashibe, Mia (Division of Public Health, Department of Family and Preventive Medicine, and Huntsman Cancer Institute, University of Utah School of Medicine)
  • Published : 2015.12.03

Abstract

Background: The aim of this study was to investigate whether family history of cancer is associated with head and neck cancer risk in a Chinese population. Materials and Methods: This case-control study included 921 cases and 806 controls. Recruitment was from December 2010 to January 2015 in eight centers in East Asia. Controls were matched to cases with reference to sex, 5-year age group, ethnicity, and residence area at each of the centers. Results: We observed an increased risk of head and neck cancer due to first degree family history of head and neck cancer, but after adjustment for tobacco smoking, alcohol drinking and betel quid chewing the association was no longer apparent. The adjusted OR were 1.10 (95% CI=0.80-1.50) for family history of tobacco-related cancer and 0.96 (95%CI=0.75-1.24) for family history of any cancer with adjustment for tobacco, betel quid and alcohol habits. The ORs for having a first-degree relative with HNC were higher in all tobacco/alcohol subgroups. Conclusions: We did not observe a strong association between family history of head and neck cancer and head and neck cancer risk after taking into account lifestyle factors. Our study suggests that an increased risk due to family history of head and neck cancer may be due to shared risk factors. Further studies may be needed to assess the lifestyle factors of the relatives.

Keywords

Head and neck cancer;family history of cancer

Acknowledgement

Supported by : National Institutes of Health

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