Anti-protozoal effect of organic acids against Azumiobodo hoyamushi that causes soft tunic syndrome to Halocynthia roretzi

멍게 물렁증의 원인충인 Azumiobodo hoyamushi에 대한 유기산의 살충효과 연구

Lee, Ji Hoon;Park, Kyung Il;Park, Kwan Ha

  • Received : 2015.09.08
  • Accepted : 2015.12.10
  • Published : 2015.12.30


Economic loss by soft tunic syndrome of edible ascidian, Halocynthia roretzi has become a serious problem. Recently, it has discovered that the cause of this syndrome is infection by a protozoan parasite Azumiobodo hoyamushi. However, only a few studies have been conducted to control this parasitic disease. In a previous research, non-specific disinfectants have been found to be effective in controling the causative parasite. In an attempt to eradicate this causative parasite, organic acids were tested in this study to evaluate their in vitro and in vivo efficacy. In vitro tests showed that 8 different organic acids used in this study were moderately or highly effective with protozoan-killing effects ($EC_{50}=153{\sim}275{\mu}g/ml$). Despite weak in vivo penetration of organic acids into the tunic tissues, treatment with high concentration reduced the mortality of ascidian caused by infection the parasite, indicating that we might be able to develop a disinfection method using environmentally-friendly organic acids.


Ascidian Halocynthia roretzi;Azumiobodo hoyamushi;Organic acids;Anti-parasitic effect


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