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Physical Properties of the Hydrogel Using Alginate

Alginate가 포함된 하이드로겔의 물리적 특성

  • Received : 2015.11.02
  • Accepted : 2015.12.22
  • Published : 2015.12.31

Abstract

Purpose: A hydrogel including alginate and $CaCl_2$ extracted from seaweed was manufactured, and their physical properties were investigated. Also, its applicability as contact lenses was examined. Methods: A film-type sample used in this experiment was manufactured using 2-hydroxyethyl methacrylate (HEMA), which is the raw material of hydrogel contact lenses; azobisiobutyonitile (AIBN), which is an initiator and ethylenglycoldimethacrylate (EGDMA), which is a cross-linking agent. It was hydrated in a PBS solution for 24 hours, and an interpenetrating polymer network (IPN) was formed in 1% and 2% alginate and 1%, 3%, and 5% $CaCl_2$ solutions for 24 hours, respectively. Results: The measurement of the physical properties of the film after the IPN showed that the moisture content was 30.89~36.89%, the refractive index was 1.431~1.441, the contact angle was $62.98{\sim}80.45^{\circ}$, and the tensile strength was 2.378~4.215 ($gf/mm^2$). Also, the physical properties hardly changed as the content of alginate increased, and the moisture content decreased as the content of $CaCl_2$ increased. As a result of the IPN, the moisture content and contact angle decreased compared to those of basic HEMA, but the tensile strength increased. The tensile strength of the second IPN was higher than that of the first IPN. In the case of $CaCl_2$, for the sample polymerized for 24 hours and the second IPN sample with 2% alginate, the contact angle decreased as the content of $CaCl_2$ increased. Conclusions: In this study, the tensile strength increased as the content of $CaCl_2$ increased, and the wettability increased as a result of IPN of alginate and $CaCl_2$. The hydrogel containing the alginate and $CaCl_2$ was confirmed possible utilization as contact lens material.

Keywords

Alginate;Hydrogel;IPN;Contact Angle;Water Contents;Tensile Strength

References

  1. Liesegang TJ. Physiologic Changes of the Cornea with Contact Lens Wear. CLAO J. 2002;28(1):12-27.
  2. Woo CM, Lee HM. Change of corneal shape with soft contact lens type. J Korean Ophthalmic Opt Soc. 2014;19(1):111-120. https://doi.org/10.14479/jkoos.2014.19.1.111
  3. Lee GJ, Park YJ, Park JJ. The Long-Term Effects of soft contact lens wear on corneal thickness, curvature and endothelium. J Koeran Ophthalmol soc. 2005;46(6):945-953.
  4. Tyagi G, Collins M, Read S, Davis B. Regional changes in corneal thickness and shape with soft contact lenses. Optom Vis Sci. 2010;87(8):567-575. https://doi.org/10.1097/OPX.0b013e3181e61b78
  5. Read SA, Collins MJ. Diurnal variation of corneal shape and thickness. Optom Vis Sci. 2009;86(3):170-80. https://doi.org/10.1097/OPX.0b013e3181981b7e
  6. Kim TH, Cho SA, Sung AY. Study on the physical properties of soft contact lens materials with isocyanate group for durability improvement. Korean J Vis Sci. 2011;13(2): 127-137.
  7. Lee HM, Park HJ. Changes in drug elution concentration and physical characteristicsof soft contact lenses depending on the initiator and crosslinker. J Korean Ophthalmic Opt Soc. 2014;19(2):145-151. https://doi.org/10.14479/jkoos.2014.19.2.145
  8. Jin J, Ryu GC, Jin MS, Chae SC, Kim IS. Elution properties of naringin from soft contact lens containing naringin. J Korean Ophthalmic Opt Soc. 2008;13(3): 45-50.
  9. Kang U, Kim SR, Seo BM, Park M. A study on dye elution from the circle contact lenses. J Korean Ophthalmic Opt Soc. 2014;19(2):171-177. https://doi.org/10.14479/jkoos.2014.19.2.171
  10. Nichols JJ. Contact lenses 2013. Contact Lens spectrum, 2014;29:22-28.
  11. Yang CH, Wang MX, Haider H, Yang JH, Sun JU, Chen YM et al. Strengthening alginate/polyacrylamide hydrogels using various multivalent cations. Applied Materials & Imterfaces. 2013;5(21):10418-104122. https://doi.org/10.1021/am403966x
  12. Olav Smidsrod, Gudmund Skjak-Brk. Alginate as Immobilization matrix for cells. trends in biotechnology. 1990; 8;71-78. https://doi.org/10.1016/0167-7799(90)90139-O
  13. Lee HM, Kim JK, Cho TS. Antimicrobial hydrogel contact lens containing alginate. Bull Kor Chem Soc. 2011; 32(12):4239-4243. https://doi.org/10.5012/bkcs.2011.32.12.4239
  14. Lee HM, Yoon YH, Lee WB, Kim JK. A gel-forming poly-L-gyluronic acid produced from no guluronate-rich marine algae using new hydrolysis method: test for endovascular emboization. J. Mater Sci: Mater Med. 2009;20:1917-1926. https://doi.org/10.1007/s10856-009-3758-5
  15. Eiselt P, Yeh J, Latvala RK, Shea LD, Mooney DJ. Porous carriers for biomedical applications based on alginate hydrogels. biomaterials, 2000;21(19):1921-1927. https://doi.org/10.1016/S0142-9612(00)00033-8
  16. Goh CH, Heng PW, Huang EP, Li BK, Chan LW. Interactions of antimicrobial compounds with cross-linking agents of alginate dressings. J Antimicrob Chemother. 2008;62(1):105-108. https://doi.org/10.1093/jac/dkn168
  17. Hennink WE, Talsma H, Borchert JCH, De Smedt SC, Demeester J. Controlled release of proteins from dextran hydrogels. Journal of controlled release. 1996;39(1):47-55. https://doi.org/10.1016/0168-3659(95)00132-8
  18. You BJ, Lim YS. Effect of emulsifying conditions and alginate concentration of encapsulation ester compounds on retention rate of core material in microcapsules prepared with sea tangle alginates. J Korean Fish Soc. 2002; 35(6):654-659.

Acknowledgement

Supported by : 한국연구재단