Effect of Dropwort (Oenanthe javanica) Extracts on Memory Improvement in Alzheimer's Disease Animal Model, Tg2576 mice

알츠하이머질병 모델동물인 Tg2576 마우스를 이용한 미나리 알코올추출물의 기억력 개선 효능

  • Won, Beom Young (Research & Development Center, Braintropia Co., Ltd.) ;
  • Shin, Ki Young (Department of Microbiology, College of Natural Science, Dankook University) ;
  • Ha, Hyun Jee (Research & Development Center, Braintropia Co., Ltd.) ;
  • Chang, Keun-A (Department of Pharmacology, Gachon University of Medicine and Science) ;
  • Yun, Yeo Sang (Research & Development Center, Braintropia Co., Ltd.) ;
  • Kim, Ye Ri (Research & Development Center, Braintropia Co., Ltd.) ;
  • Park, Yong Jin (Research & Development Center, Braintropia Co., Ltd.) ;
  • Lee, Hyung Gun (Research & Development Center, Braintropia Co., Ltd.)
  • 원범영 ((주)브레인트로피아 기업부설연구소) ;
  • 신기영 (단국대학교 자연과학대학 미생물학과) ;
  • 하현지 ((주)브레인트로피아 기업부설연구소) ;
  • 장근아 (가천대학교 메디컬캠퍼스 약리학과) ;
  • 윤여상 ((주)브레인트로피아 기업부설연구소) ;
  • 김예리 ((주)브레인트로피아 기업부설연구소) ;
  • 박용진 ((주)브레인트로피아 기업부설연구소) ;
  • 이형근 ((주)브레인트로피아 기업부설연구소)
  • Received : 2015.10.12
  • Accepted : 2015.12.10
  • Published : 2015.12.31


This study was conducted to investigate the effect of herbs on memory improvement by focusing on their cholinergic functions in Tg2576 mice. Seven herbs were used to obtain extracts by using alcohol and water. In screening test for cholinergic activities of the extracts, acetylcholinesterase (AChE) activity was highly inhibited in Oenanthe javanica alcohol extract (OJAE, 18.76%) as compared with the others. The OJAE-treated Tg2576 (Tg-OJAE) groups showed the statistically significant increases of latency time in passive avoidance test. Also, it was found that the concentration of $A{\beta}1-42$ was significantly reduced in Tg-OJAE groups compared to non-treated Tg2576 groups. In the additional enzyme test, it was found that $IC_{50}$ of OJAE was $991.77{\mu}g/mL$ and OJAE acted as an uncompetitive inhibitor of AChE. Therefore, it seemed that OJAE can be used for the development of processed foods for memory improvement.


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