Heating Characteristics Evaluation of Superposed Sonication Using Glycerol Tissue Mimic Phantom

글리세롤 조직유사 팬텀을 이용한 초음파 중첩 조사에 따른 가열 특성 평가

Noh, Si-Cheol;Kang, Sang-Sik;Park, Ji-Koon;Kim, Ju-Young;Jung, Bong-Jae

  • Received : 2015.10.23
  • Accepted : 2015.12.25
  • Published : 2015.12.31


In this study, we evaluated the heating characteristics of single sonication and superposed two low-intensity ultrasonic sonication. Compare the results, the superposed sonication was showed a superior thermal effect than single sonication. And the maximum temperature was increased as 120-150%. The starting time of temperature rising has been shortened in superposed sonication. In addition, the time up to the maximum temperature has been shortened, too. In generally, as the ultrasonic intensity is higher, the more surface damage is occurred. However, in the case of superposed sonication, the same thermal effect had be confirmed without surface damage. Through the results of the study, we thought that the superposed sonication will be able to reduce the intensity of the ultrasonic treatment. And, by using the low-intensity, the more safe and more effect therapy will be possible in therapeutic ultrasound application.


superposed sonication;heating characteristic;therapeutic ultrasound;glycerol tissue mimic phantom


  1. M. R. Bailey, V. A. Khokhlova, O. A. Sapozhnikov, et al., "Physical Mechanisms of the Therapeutic Effect of Ultrasuond(A Review)", Acoustic Physics, Vol. 49, No. 4, pp.437-464, 2003.
  2. Sanghvi Narendra T., R. H. Hawes, "High-intensity focused ultrasound." Gastrointest Endosc Clin N Am., Vol. 4, No. 2, pp.383-395, 1994.
  3. Iernetti G., Ciuti P., Dezhkunov, et al., "Enhancement of high-frequency acoustic cavitation effects by a low-frequency stimulation." Ultrasonics sonochemistry, Vol. 4, No. 3, pp.263-268, 1997.
  4. Feng Ruo, Yiyun Zhao, Changping Zhu, et al., "Enhancement of ultrasonic cavitation yield by multi-frequency sonication." Ultrasonics sonochemistry, Vol. 9, No. 5, pp.231-236, 2002.
  5. Y. S. Tung, H. L. Liu, C. C. Wu, et al., "Contrast-agentenhanced ultrasound thermal ablation.", Ultrasound in medicine & biology, Vol. 32, No. 7, pp.1103-1110, 2006.
  6. Holt, R. Glynn, Ronald A. Roy. "Measurements of bubbleenhanced heating from focused, MHz-frequency ultrasound in a tissue-mimicking material.", Ultrasound in medicine & biology, Vol. 27, No. 10, pp.1399-1412, 2001.
  7. Krasovitski, Boris, Hanoch Kislev, Eitan Kimmel, "Modeling photothermal and acoustical induced microbubble generation and growth.", Ultrasonics, Vol. 47, No. 1, pp.90-101, 2007.
  8. T. Yu, G. Wang, K. Hu, et al., "A microbubble agent improves the therapeutic efficiency of high intensity focused ultrasound: a rabbit kidney study", Urol Res. Vol. 32, pp.14-19, 2004.
  9. J. H. Min, J. Y. Kim, S. C. Noh, et. al., "Development of Human-Head-Mimicking Phantom for Brain Treatment Using Focused Ultrasound", J. Korean. Soc. Radiol., Vol. 7, No. 6, pp.433-439, 2013.
  10. Ran Fu, Tong-Yi Zhang, "Effects of an Electric Field on the Fracture Toughness of Poled Lead Zirconate Titanate Ceramics", J. Am. Ceram. Soc., Vol. 83, No. 5, pp.1215-18, 2000.


Supported by : International University of Korea