The Latest Trends of Treatment for Alopecia

탈모 치료에 관한 최신 동향

  • Received : 2015.10.14
  • Accepted : 2015.11.15
  • Published : 2015.11.25


Objective : The purpose of this study is to analyse research trend on alopecia including androgenetic alopecia, alopecia areata, etc.Methods : We searched Pubmed, CNKI and OASIS on the title "alopecia" in recent 5 years.Results : We found 23 studies on Pubmed, 20 on CNKI, and 3 on OASIS about treatments of alopecia. The subjects of them were about 5α-reductase inhibitor, Minoxidil, steroids, immunosuppression, laser therapy, PRP, microneedling, stem cell, herbal medicine, integrative medicine, external treatments and syndrome differentiation.Conclusions : In recent studies in western medicine were about combination therapy or safety and presented validities and superiorities about new treatments. Integrative medicine, external treatment and researches about patients' characteristics were reported in TCM. Korean medicine has advantages of considering whole body and phychological problems.


Alopecia;Treatment;Integrative medicine


  1. Jang HY, Choi KH, Kim SH, Kwon KR, Kim BW. Bibliographic Studies of Depilation. 2002;5(2):92-108.
  2. Jung JY, Han KH. Common Skin Disease in Korea. Seoul:MDWorld. 2009:495-522.
  3. Min BG. Diagnosis and treatment of hair &scalp disorders. Seoul:Hanmi Book. 2005:21-3,30.
  4. Messenger AG, Rundegren J. Minoxidil:mechanisms of action on hair growth. Br J Dermatol. 2004 Feb;150(2):186-94.
  5. Chandrashekar BS, Nandhini T, Vasanth V, Sriram R, Navale S. Topical minoxidil fortified with finasteride: An account of maintenance of hair density after replacing oral finasteride. Indian Dermatol Online J. 2015 Jan-Feb;6(1):17-20.
  6. Boersma IH, Oranje AP, Grimalt R, Iorizzo M, Piraccini BM, Verdonschot EH. The effectiveness of finasteride and dutasteride used for 3 years in women with androgenetic alopecia. Indian J Dermatol Venereol Leprol. 2014 Nov-Dec;80(6):521-5.
  7. Oliveira-Soares R, E Silva JM, Correia MP, André MC. Finasteride 5 ㎎/day Treatment of Patterned Hair Loss in Normo-androgenetic Postmenopausal Women. Int J Trichology. 2013 Jan;5(1):22-5.
  8. Levy LL, Emer JJ. Female pattern alopecia:current perspectives. Int J Womens Health. 2013;5:541–56.
  9. Kim HJ, Chae BY. A Clinical Study of Alopecia. J Orient Med Surg Opthalmol Otolaryngol. 1996;9(1):166-72.
  10. Jang HY, Choi KH, Kim SH, Kwon KR, Kim BW. Bibliographic Studies of Depilation. J Pharmacopuncture. 2002;5(2):92-108.
  11. Kim NW, Noh SS. A literatual studies on the yupung. J Orient Med Surg Opthalmol Otolaryngol. 1998;11(1):162-79.
  12. Lee YJ. A Bibliographical Study of Oriental Medical Records on Alopecia. J. of Kor Orient Med Society. 1995;16(1):141-59.
  13. Lee PR, Ahn KS. A Literatural Investigation into Pathology of Alopecia Areata. J. of Orient Med Pathol. 1991;7:111-20.
  14. Yim SBN, Choi GD, Kim SK. A literature study about the comparison of Oriental-Occidental medicine on the alopecia. The J of Jehan oriental medical academy. 1999;4(1):699-710.
  15. Ohtsuki A, Hasegawa T, Komiyama E, Takagi A, Kawasaki J, Ikeda S. 308-nm Excimer Lamp for the Treatment of Alopecia Areata:Clinical Trial on 16 Cases. Indian J Dermatol. 2013 Jul-Aug;58(4):326.
  16. Hammerschmidt M, Mulinari Brenner F. Efficacy and safety of methotrexate in alopecia areata. An Bras Dermatol. 2014 Sep-Oct;89(5):729-34.
  17. Jabbari A, Dai ZP, Xing LZ, Cerise JE, Ramot Y, Berkun Y et al. Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib. EBioMedicine. 2015 Apr; 2(4):351–5.
  18. Park KY, Jang WS, Son IP, Choi SY, Lee MY, Kim BJ et al. Combination therapy with cyclosporine and psoralen plus ultraviolet a in the patients with severe alopecia areata: a retrospective study with a self-controlled design. Ann Dermatol. 2013 Feb;25(1):12-6.
  19. Senila SC, Danescu SA, Ungureanu L, Candrea E, Cosgarea RM. Intravenous methylprednisolone pulse therapy in severe alopecia areata. Indian J Dermatol Venereol Leprol. 2015 Jan-Feb;81(1):95.
  20. Sardesai VR, Prasad S, Agarwal TD. A study to evaluate the efficacy of various topical treatment modalities for alopecia areata. Int J Trichology. 2012 Oct;4(4):265-70.
  21. Hsu CL, Liu JS, Lin AC, Yang CH, Chung WH, Wu WG. Minoxidil may suppress androgen receptor-related functions. Oncotarget. 2014 Apr 30;5(8):2187-97.
  22. Uprit S, Kumar Sahu R, Roy A, Pare A. Preparation and characterization of minoxidil loaded nanostructured lipid carrier gel for effective treatment of alopecia. Saudi Pharm J. 2013 Oct;21(4):379-85.
  23. Sakr FM, Gado AM, Mohammed HR, Adam ANI. Preparation and evaluation of a multimodal minoxidil microemulsion versus minoxidil alone in the treatment of androgenic alopecia of mixed etiology: a pilot study. Drug Des Devel Ther. 2013;7:413–23.
  24. Dhurat R, Sukesh M, Avhad G, Dandale A, Pal A, Pund P. A randomized evaluator blinded study of effect of microneedling in androgenetic alopecia: a pilot study. Int J Trichology. 2013 Jan;5(1):6-11.
  25. Singhal P, Agarwal S, Dhot PS, Sayal SK. Efficacy of platelet-rich plasma in treatment of androgenic alopecia. Asian J Transfus Sci. 2015 Jul-Dec;9(2):159-62.
  26. Singh S. Role of platelet-rich plasma in chronic alopecia areata: Our centre experience. Indian J Plast Surg. 2015Jan-Apr;48(1):57-9.
  27. Cervelli V, Garcovich S, Bielli A, Cervelli G, Curcio BC, Scioli MG et al. The effect of autologous activated platelet rich plasma(AA-PRP) injection on pattern hair loss:clinical and histomorphometric evaluation. Biomed Res Int. 2014;2014:760709.
  28. Gkini MA, Kouskoukis AE, Tripsianis G, Rigopoulos D, Kouskoukis K. Study of platelet-rich plasma injections in the treatment of androgenetic alopecia through an one-year period. J Cutan Aesthet Surg. 2014Oct-Dec;7(4):213-9.
  29. Khatu SS, More YE, Gokhale NR, Chavhan DC, Bendsure N. Platelet-rich plasma in androgenic alopecia: myth or an effective tool. J Cutan Aesthet Surg. 2014 Apr;7(2):107-10.
  30. Avci P, Gupta GK, Clark J, Wikonkal N, Hamblin MR. Low-level laser (light) therapy (LLLT) for treatment of hair loss. Lasers Surg Med. 2014 Feb;46(2):144-51.
  31. Jimenez JJ, Wikramanayake TC, Bergfeld W, Hordinsky M, Hickman JG, Hamblin MR, et al. Efficacy and safety of a low-level laser device in the treatment of male and female pattern hair loss: a multicenter, randomized, sham device-controlled, double-blind study. Am J Clin Dermatol. 2014 Apr;15(2):115-27.
  32. Munck A, Gavazzoni MF, Trüeb RM. Use of low-level laser therapy as monotherapy or concomitant therapy for male and female androgenetic alopecia. CMAJ. 2013 Dec 10;185(18):1579–85.
  33. Zou DM. The Clinical Observation of Integrative Medicine on Alopecia Areata. Contemporary Medicine. 2010;16(34):148-9.
  34. Wei XS. The Clinical Research on Treating Androgenic Alopecia with Traditional Chinese Medicine and Western Medicine. Master Dissertation. Guangzhou University of Chinese Medicine. 2009.
  35. Hong JA, Kang SJ, Jang JY, Kang YR. A Clinical Trial on Efficacy of Gagamchengyoung-tang(Jiājiǎnqīngyíng-tāng)in the Alopecia Patients with Febrile Tendency. Korean Med Opthalmol Otolaryngol Dermatol. 2013;26(2):19-29.
  36. Zhou JJ. The Observation of Clinical Efficacy on the Androgenic Alopecia Liver and Kidney Insufficiency Which Treatded by Bu Fa Yin Combined with Ce Bai Tincture. Master Dissertation. Shandong University of Traditional Chinese Medicine. 2014.
  37. Wen Q. Clinical Observation of Qushi Jianfa Decoction on Treating Alopecia Seborrheica(Damp-Heat Fumigating Upward Type). Master Dissertation. Heilungjiang University of Chinese Medicine. 2013.
  38. Han M. The Clinical Observation of Treating and Androgenetic Alopecia by Using the Huazhi Shengfa Decoction. Master Dissertation. Chengdu University of Traditional Chinese Medicine. 2012.
  39. Ren F. The Clinical Observation of Yi Ling Qu Shi Sheng Fa Decoction on Treating Androgenic Alopecia and Analysis of Content of Elements in Hair. Master Dissertation. Nanjing University of Chinese Medicine. 2012.
  40. Li Y, Yan B, Wang H, Li H, Li Q, Zhao D, et al. Hair regrowth in alopecia areata patients following Stem Cell Educator therapy. BMC Med. 2015 Apr 20;13:87.
  41. Fukuoka H, Suga H. Hair Regeneration Treatment Using Adipose-Derived Stem Cell Conditioned Medium: Follow-up With Trichograms. Eplasty. 2015 Mar 26;15:e10.
  42. Zuo YQ, Xu TT. Clinical Observation of TCM Five Elements Music Therapy on Alopecia Areata Patients’ Depression Emotion. Hubei Journal of Traditional Chinese Medicine. 2014;36(12):14-5.
  43. Wang ZJ, Guo BQ. Clinical observation on treating 108 cases of alopecia in TCM. Clinical Journal of Chinese Medicine. 2014;6(19):74-5.
  44. Shi ZH. Clinical Observation of Treatment with Shen Ying Yang Zhen Dan Compound 640-nm Red Light for the Blood Deficiency and Wind Dryness Type of Alopecia Areata. Master Dissertation. Nanjing University of Chinese Medicine. 2014.
  45. Lin KR, Jiang YF, Yu AS. Clinical observation of Chinese comprehensive therapy on androgenetic alopecia of damp and heat in the spleen and the stomach pattern. SH. J. TCM 2014;48(8):53-6.
  46. Xiao Q, Wang C, Zhang HL, Wang G. Clinical Observation on Dermal Needle and Self-made ShengFa Tincture for Alopecia Areata. West J of Traditional Chinese Medicine. 2013;26(11):102-3.
  47. Sun YC. Traditional Chinese Medicine (TCM)Syndrome Differentiation with Finasteride Piece of Clinical Research for the Treatment of Seborrheic Alopecia. Master Dissertation. HeNan University of Traditional Chinese Medicine. 2014.
  48. Liu JW. Effect of Ear Acupuncture and Glycyrrhizin capsule on Androgenetic Alopecia. Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine. 2013;12(5):325-6.
  49. Liu M, Xie XB. Effect of Glycyrrhizin capsule and Yangxueshengfa on alopecia areata. Med J West China. 2012;24(9):1766-7.
  50. Cheng ZQ. The Clinical Observation of integrative medicine on 58 cases of alopecia areata. China Journal of Modern Medicine. 2011;21(21):2630-2.
  51. Lee SW, Ko JM, Lee SY, et al. A Case Study of Beevenom Effect on Alopecia Universalis Started from Alopecia Areata. The Acupuncture. 2008;25(6);163-73.
  52. Oriental Medical School physiology professors. Oriental Oriental physiology. Paju:Jipmoondang. 2008;15,154,423,428.
  53. Lee JH, Jang JY, Yoon YJ, Cho AR, Shin HJ, Jung SU, et al. Retrospective Study about the Causes and the Effects of Korean Medicine Treatment on Alopecia. Focused on Acquired Febrile Alopecia. Korean Med Opthalmol Otolaryngol Dermatol. 2013;26(2):30-44.
  54. Lee TH, Moon JB, Jeong JH, Leem KH, Kim HT. A Study of Clinical features and classification of Alopecia patients in Korean medical clinic. J Korean Med Opthalmol Otolaryngol Dermatol. 2009;22(3);153-66.
  55. Qiu J, Zheng MX, Chen CP. The Clinical Observation of Chinese Medicine Syndrome Differentiation on 124 cases of Androgenic Alopecia. Nei Mongol Journal of Traditional Chinese Medicine. 2015;4:41-2.
  56. Park MJ, Zhao HZ, Zhao WB, Zeng WX, Yang DQ, Bai YP. Research on Constitution Types of Chinese Medicine and Psychological Assessment in Patients with Alopecia Areata and Relation Analysis. Chin J Dermato Venerol Integ Trad W Med. 2014;13(2):89-92.
  57. Qin Z. Correlation Research of Clinical Investigation of Androgenic Alopecia and Syndrome Differentiation Based on Chinese Medicine. Master Dissertation. Nanjing University of Chinese Medicine. 2014.
  58. Huang J. Investigation and Analysis on Syndrome Differentiation-type and Constitution of TCM of Androgenetic Alopecia. Master Dissertation. Guangzhou University of Chinese Medicine. 2012.
  59. Jiang Y. The Electron Telescope Study on Traditional Chinese Medicine and Western Medicine Syndrome Differentiation and Typing in Androgenetic Alopecia. Master Dissertation. Nanjing University of Chinese Medicine. 2009.
  60. Yoon HJ. A Case Study of Androgenetic Alopecia in woman Improved by Pharmacopuncture Therapy and Needleembedding Therapy. J Korean Med Ophthalmol Otolaryngol Dermatol. 2014;27(3):162-70.
  61. Yun JH, Kim KH, Jang SJ, Sin MS. One Case treated Alopecia Areata with Herbal Acupuncture. J Orient Med Surg Opthalmol Otolaryngol. 2001;14(1):105-10.
  62. Yi TH, Moon JB, Kim YJ, An KE. Oriental Medicine Therapy in the Treatment of Men with Androgenetic Alopecia. J Kor Acupunct & Moxibus Society. 2006;23(1):179-86.

Cited by

  1. A Statistical Analysis of Outpatients in Dermatology of Korean Medicine at Kyung Hee University Korean Medicine Hospital in 2011-2015 vol.29, pp.3, 2016,