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Synergistic Anti-diabetic Effect of Cirsium setidens Combined with Other Plants in vitro and in vivo

  • Huifang, Guo ;
  • Jiang, Yunyao ;
  • Wang, Myeong-Hyeon
  • Received : 2015.11.17
  • Accepted : 2015.12.07
  • Published : 2015.12.31

Abstract

The anti-diabetic effect of Cirsium setidens water extract and the combinations with Bletilla striata, Cymbidium kanran, and Sparganium stoloniferum Buch.-Ham. ethanolic extracts had been studied. The combination of four extracts (3:1:1:1) showed larger anti-diabetic activity in vitro and in vivo. It is notable that the single water extract from C. setidens exhibited more effective anti-diabetic effect than most of the combinations. We also investigated whether fermentation process was promoted the anti-diabetic activity. The data suggested the fermentation product of combination of four extracts (3:1:1:1) exhibited the strongest activity both in vitro and in vivo, which was higher than the non-fermented group. The result indicated the fermentation and the appropriate combination of extracts enhanced the anti-diabetes activity.

Keywords

Anti-diabetes;Cirsium setidens;Hypoglycemic;Synergistic

References

  1. Choi, J.W., W.B. Kim, J.H. Nam and H.J. Park. 2007. Antidiabetic effect of the methanolic extract of Ligularia stenocephala leaves in the streptozotocin-induced rat. Korean J. Plant Res. 20(4):362-366.
  2. Bhandari, M.R., N. Jong-Anurakkun, G. Hong and J. Kawabata. 2008. α-Glucosidase and α-amylase inhibitory activities of Nepalese medicinal herb Pakhanbhed (Bergenia ciliata, Haw.). Food Chem. 106(1):247-252. https://doi.org/10.1016/j.foodchem.2007.05.077
  3. Balon, T.W., A.P. Jasman and J.S. Zhu. 2002. A fermentation product of Cordyceps sinensis increases whole-body insulin sensitivity in rats. J. Altern. Complement. Med. 8(3):315-323. https://doi.org/10.1089/10755530260128005
  4. Atangwho, I.J., P.E. Ebong, E.U. Eyong, M.Z. Asmawi and M. Ahmad. 2012. Synergistic antidiabetic activity of Vernonia amygdalina and Azadirachta indica: Biochemical effects and possible mechanism. J. Ethnopharmacol. 141(3):878-887. https://doi.org/10.1016/j.jep.2012.03.041
  5. Martins, S., S.I. Mussatto, G. Martínez-Avila, J. Montañez-Saenz, C.N. Aguilar and J.A. Teixeira. 2011. Bioactive phenolic compounds: Production and extraction by solid-state fermentation. A review. Biotechnol. Adv. 29(3):365-373. https://doi.org/10.1016/j.biotechadv.2011.01.008
  6. Kim, Y.M., Y.K. Jeong, M.H. Wang, W.Y. Lee and H.I. Rhee. 2005. Inhibitory effect of pine extract on α-glucosidase activity and postprandial hyperglycemia. Nutrition 21(6): 756-761. https://doi.org/10.1016/j.nut.2004.10.014
  7. Kim, H.S., T.W. Kim, D.J. Kim, J.S. Lee, K.K. Kim and M. Choe. 2013. Antioxidant activities and α-glucosidase inhibitory effect of water extracts from medicinal plants. Korean J. Med. Crop. Sci. 21(3):197-203. https://doi.org/10.7783/KJMCS.2013.21.3.197
  8. Kim, H.Y., S.H. Lim, Y.H. Park, H.J. Ham, K.J. Lee, D.S. Park, K.H. Kim and S.M. Kim. 2011. Screening of α-amylase, α-glucosidase and lipase inhibitory activity with Gangwon-do wild plants extracts. J. Korean. Soc. Food. Sci. Nutr. 40(2): 308-315. https://doi.org/10.3746/jkfn.2011.40.2.308
  9. Gilbert, B. and L. Alves. 2003. Synergy in plant medicines. Curr. Med. Chem. 10(1):13-20. https://doi.org/10.2174/0929867033368583
  10. Ezuruike, U.F. and J.M. Prieto. 2014. The use of plants in the traditional management of diabetes in Nigeria: Pharmacological and toxicological considerations. J. Ethnopharmacol. 155(2): 857-924. https://doi.org/10.1016/j.jep.2014.05.055
  11. Ernst, E. 1997. Plants with hypoglycemic activity in humans. Phytomedicine 4(1):73-78. https://doi.org/10.1016/S0944-7113(97)80031-1
  12. Đorđević, T.M., S.S. Šiler-Marinković and S.I. Dimitrijević-Branković. 2010. Effect of fermentation on antioxidant properties of some cereals and pseudo cereals. Food Chem. 119(3): 957-963. https://doi.org/10.1016/j.foodchem.2009.07.049
  13. Cnop, M., N. Welsh, J.C. Jonas, A. Jörns, S. Lenzen and D.L. Eizirik. 2005. Mechanisms of pancreatic β-cell death in type 1 and type 2 diabetes many differences, few similarities. Diabetes 54 (suppl. 2):S97-S107. https://doi.org/10.2337/diabetes.54.suppl_2.S97
  14. Sharma, S., M. Choudhary, S. Bhardwaj, N. Choudhary and A.C. Rana. 2014. Hypoglycemic potential of alcoholic root extract of Cassia occidentalis L. in streptozotocin induced diabetes in albino mice. Bulletin of Faculty of Pharmacy. Cairo University. 52(2):211-217. https://doi.org/10.1016/j.bfopcu.2014.09.003
  15. Reddy, N.R. and M.D. Pierson. 1994. Reduction in antinutritional and toxic components in plant foods by fermentation. Food Res. Int. 27(3):281-290. https://doi.org/10.1016/0963-9969(94)90096-5
  16. Rasoanaivo, P., C.W. Wright, M.L. Willcox and B. Gilbert. 2011. Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions. Malar. J. 10(Suppl. 1):S4. https://doi.org/10.1186/1475-2875-10-S1-S4
  17. Park, J.H., Y. Yin and M.H. Wang. 2010. Antioxidant and anti-diabetes activities of methanolic extract and fractions of Astragalus membranaceus roots. J. Food. Nutr. 15(1):30-35. https://doi.org/10.3746/jfn.2010.15.1.030
  18. Park, H.J., D.H. Jung, H.M. Joo, N.S. Kang, S.A. Jang, J.G. Lee and E.H. Sohn. 2010. The comparative study of anti-allergic and anti-inflammatory effects by fermented red ginseng and red ginseng. Korean J. Plant Res. 23(5):415-422.
  19. nee’Nigam, P.S. 2009. Production of bioayctive secondary metabolites: In Nigam, P.S.N and A. Pandey (eds.), Biotechnology for Agro-Industrial Residues Utilisation, Springer Science & Business Media, Dordreeht, Netherlands. pp. 129-145.
  20. Mitra, A. 2008. Some salient points in dietary and life-style survey of rural Bengal particularly tribal populace in relation to rural diabetes prevalence. Ethno Med. 2(1):51-56. https://doi.org/10.1080/09735070.2008.11886315
  21. McCue, P.P. and K. Shetty. 2004. Inhibitory effects of rosmarinic acid extracts on porcine pancreatic amylase in vitro. Asia Pac. J. Clin. Nutr. 13(1):101-106.
  22. Mccue, P., Y.I. Kwon and K. Shetty. 2005. Anti‐amylase, anti‐glucosidase and anti‐angiotensin i‐converting enzyme potential of selected foods. J. Food Biochem. 29(3):278-294. https://doi.org/10.1111/j.1745-4514.2005.00020.x
  23. Yu, L., X. Nie, H. Pan, S. Ling, D. Zhang and K. Bian. 2011. Diabetes mellitus ulcers treatment with Bletilla striata polysaccharide. Zhongguo Zhong Yao Za Zhi 36(11):1487-1491.
  24. Xu, M.L., L. Wang, J.H. Hu and M.H. Wang. 2009. Antioxidant and α-glucosidase inhibitory activities of the extract from Sparganium stoloniferum Buch.-Ham. root and its constituent compounds. J. Food. Nutr. 14(4):354-357. https://doi.org/10.3746/jfn.2009.14.4.354
  25. Tiwari, A.K. and J. Madhusudanarao. 2002. Diabetes mellitus and multiple therapeutic approaches of phytochemicals: Present status and future prospects. Curr. Sci. 83(1):30-38.
  26. Sunil, C., G. Latha, P. Mohanraj, K. Kalichelvan and P. Agastian. 2009. α-Glucosidase inhibitory and antidiabetic activities of ethanolic extract of Pisonia alba Span. leaves. Int. J. Integr. Biol. 6(1):41-45.
  27. Shaw, J.E., R.A. Sicree and P.Z. Zimmet. 2010. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res. Clin. Pract. 87(1):4-14. https://doi.org/10.1016/j.diabres.2009.10.007