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Prediction of Hypoxia-inducible Factor Binding Site in Whale Genome and Analysis of Target Genes Regulated by Predicted Sites

고래의 게놈에서 hypoxia-inducible factor binding site의 예측과 target gene에 대한 분석

  • Received : 2015.10.26
  • Accepted : 2015.11.03
  • Published : 2015.12.31

Abstract

Whales are marine mammals that are fully adapted to aquatic environment. Whales breathe by lungs so they require adaptive system to low oxygen concentration (hypoxia) while deep and prolonged diving. However, the study for the molecular mechanism underlying cetacean adaptation to hypoxia has been limited. Hypoxia-inducible factor (HIF) is the central transcription factor that regulates hypoxia-related gene expression. Here we identified HIF-binding sites in whale genome by phylogenetic footprinting and analyzed HIF-target genes to understand how whales cope with hypoxia. By comparison with the HIF-target genes of terrestrial mammals, it was suggested that whales may retain unique adaptation mechanisms to hypoxia.

Keywords

whale;hypoxia;HIF (hypoxia-inducible factor);HIF-target gene;adaptation mechanism

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Acknowledgement

Supported by : 한국해양과학기술원