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Anti-asthmatic activities of Cypress oil in a mouse model of allergic asthma

마우스 모델을 이용한 사이프러스 오일의 알러지성 천식 억제 효과

  • 승윤철 (대전대학교 보건스포츠 대학원 대체의학과) ;
  • 정규진 (충남대학교 약학대학 약학과) ;
  • 정광조 (대전대학교 뷰티건강관리학과)
  • Received : 2014.10.07
  • Accepted : 2015.01.20
  • Published : 2015.01.28

Abstract

This study was aimed to evaluate the effects of Cypress oil(CS) on anti-asthmatic activities in a mouse model of allergic asthma. Using an Ovalbumin-induced allergic asthma mouse model, 0.3% of CS was administered to experimental group using a nebulizer for 3 weeks on a basis of 3 times per week and 30min each time. The degree of airway hypersensitivity, the number of eosinophil in white blood cells, the number of immune cells and the change of cytokine in lung tissue were evaluated. The degree of airway hypersensitivity, the number of eosinophil, IL-5 and IL-13 levels in lung tissue, IgE in serum, the number of CCR3, CD3, CD4 cells were significantly decreased in experimental group treated with CS. These results suggested that CS may have a positive effects on Th2 cytokine and eosinophils which are major factors of asthma responses. Therefore CS might be of therapeutic value in treating asthma.

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