Hazards of Chloroprene and the Workplace Management

클로로프렌의 유해성과 작업환경 관리

Kim, Hyeon-Yeong;Lim, Cheol-Hong

  • Received : 2015.03.30
  • Accepted : 2015.05.08
  • Published : 2015.06.28


In this study, we performed risk assessment of chloroprene by hazard evaluation and workplace investigation. The chemical is used to manufacture of shoes, tires, adhesives, and classified as IARC category 2B (possibly carcinogenic to humans) and target organ systemic toxicity. It is used about 1,300 tons per year in 27 sites. It was calculated the risk of carcinogenesis with chloroprene by Monte-carlo simulation that the averages are 2,199 and 26,404 in each case of working less than 15 minutes per day with local exhaust ventilation and over 4 hours per day without local exhaust ventilation. The risk of target organ systemic toxicity are 4.10 and 169.06 with high correlation with working time to be longer and with ventilation system. Therefore, it is recommended that the local exhaust ventilation and respirators to prevent occupational cancer and target organ systemic toxicity with chloroprene. Especially it is determined that there is a need to strengthen the workplace exposure limit (TWA 10 ppm) in Korea since it is managed with TWA less than 5 ppm ($18mg/m^3$) by the United States Occupational Safety and Health Administration (OSHA) as well as it has carcinogenicity, reproductive toxicity.


chloroprene;hazard;eisk assessment;dose-response


  1. Chemical Management Association, Survey of chemical substances in circulation, Chemical Management Association, (2012)
  2. Joint government departments(Ministry of Education, Science and Technology, Ministry of Knowledge Economy, Ministry of Environment, Ministry of Employment and Labor), "Management of chemicals in the human health and environmental hazards decrease the level of advanced countries", National Chemicals Management Master Plan(2011-2020), (2011)
  3. Byeon S.H., Choi H.C., and Park H.J., hazard․risk assessment of toxic chemicals. Occupational Safety and Health Research Institute, (2010)
  4. OSHA, "Occupational Safety and Health Act", USA, (1990)
  5. AIHA, General procedures for limit of detection calculations in the industrial hygiene chemistry laboratory Appl Ind Hyg 1(3):153-155 Burkart-JA, (1986)
  6. NTP. "Toxicology and carcinogenesis studies of chloroprene (CAS No. 126-99-8) in F344/N rats and B6C3F1 mice (inhalation studies)", Research Triangle Park, NC, (1998)
  7. NTP. Report on carcinogens 11th ed, Research Triangle Park, NC, (2005)
  8. Dong Q.A., Xiao B.L., Hu Y.H., and Li S.Q., "Short-term test for the induction of lung tumor in mouse by chloroprene", Biomed Environ Sci, 2, 150-153, (1989)
  9. Trochimowicz H.J., Loser E., Feron V.J., Clary J.J., and Valentine R., "Chronic inhalation toxicity and carcinogenicity studies on ${\beta}$-chloroprene in rats and hamsters", Inhal Toxicol, 10, 443-472, (1998)
  10. Appelman L.M., and Dreef-van der Meulen H.C., Reproduction study with beta-chloroprene vapour in rats (Report No. 6225), Zeist, Netherlands, (1979)
  11. Sanotskii I.V., "Aspects of the toxicology of chloroprene: Immediate and long-term effects", Environ Health Perspect, 17, 85-93, (1976)
  12. Himmelstein M.W., Gladnick N.L., Donner E.M., Snyder R.D., and Valentine R., "In vitro genotoxicity testing of (1-chloroethenyl) oxirane a metabolite of beta-chloroprene" Chem Biol Interact, 703-713, (2001)
  13. Pell S., "Mortality of workers exposed to chloroprene", J Occup Environ Med, 20, 21-29, (1978)