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Effect of Angelica gigas extract powder on progress of osteoarthritis induced by monosodium iodoacetate in rats

참당귀 추출분말이 Monosodium Iodoacetate로 유발된 흰쥐의 골관절염에 대한 효과

  • Kwon, Jin-Hwan (Natural Products Medical Research Institute, Nutragen Co.) ;
  • Han, Min-Seok (Natural Products Medical Research Institute, Nutragen Co.) ;
  • Lee, Bu-Min (College of Pharmacy, Chungbuk National University) ;
  • Lee, Yong-Moon (College of Pharmacy, Chungbuk National University)
  • 권진환 (뉴트라젠 천연물의학연구소) ;
  • 한민석 (뉴트라젠 천연물의학연구소) ;
  • 이부민 (충북대학교 약학대학 생물분석화학교실) ;
  • 이용문 (충북대학교 약학대학 생물분석화학교실)
  • Received : 2015.01.09
  • Accepted : 2015.02.23
  • Published : 2015.02.25

Abstract

To study the efficacy of extract powder of Angelica gigas in preventing and treating degeneration of the articular cartilage in rats with monosodium iodoacetate (MIA)-induced osteoarthritis, A total of 30 six-week-old Sprague-Dawley rats were randomly divided into normal control group, untreated group and Angelica gigas treated group, with 10 rats in each group. During the treatment period, body weight were measured in each four days interval from starting date. The rat were sacrificed at the end of 3rd week after daily administration of Angelica gigas and then rat tibia articular cartilage was removed. In articular cartilages, glycosaminoglycan (GAG) amount increased by MIA treatment were reduced while proteoglycan (PG) amount decreased by MIA treatment were fairly recovered by Angelica gigas treatment, respectively. The content of TNF-a was also slightly reduced sections of the cartilage were stained with safranin-0 were also partially recovered by Angelica gigas treatment. By HPLC analysis, the content of main compounds decursin and decursinol angelate was analyzed as $10.5{\pm}0.2%$ of total extracts.

Keywords

Angelica gigas;monosodium iodoacetate;osteoarthritis;glycosaminoglycan;proteoglycan

Acknowledgement

Supported by : 충북대학교

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