DOI QR코드

DOI QR Code

Effects of 60-Hz Magnetic Fields on DNA Damage Responses in HT22 Mouse Hippocampal Cell Lines

Mun, Gil-Im;Lee, Seungwoo;Kim, Nam;Lee, Yun-Sil

  • 투고 : 2015.04.06
  • 심사 : 2015.05.21
  • 발행 : 2015.07.31

초록

Previously, we investigated extremely low-frequency magnetic fields (ELF-MFs) on diverse DNA damage responses, such as phosphorylated H2AX (${\gamma}H2AX$), comet tail moments, and aneuploidy production in several non-tumorigenic epithelial or fibroblast cell lines. However, the effect of ELF-MF on DNA damage responses in neuronal cells may not be well evaluated. Here, we investigated the effects of ELF-MF on the DNA damage responses in HT22 non-tumorigenic mouse neuronal cells. Exposure to a 60-Hz, 2 mT ELF-MF did not produce any increased ${\gamma}H2AX$ expression, comet tail moments, or aneuploidy formation. However, 2 mT ELF-MF transiently increased the cell number. From the results, ELF-MF could affect the DNA damage responses differently, depending on the cell lines.

키워드

Aneuploidy;Cell Lines;Comet Tail;Extremely Low Frequency;${\gamma}H2AX$

참고문헌

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과제정보

연구 과제 주관 기관 : Ministry of Food and Drug Safety