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Inhibitory Activities of Ethanol Extracts from Saururus chinensis L. against Stress-Induced Hemorrhagic Gastritis

삼백초 에탄올 추출물의 위출혈성 스트레스 위염 억제 효과

  • Park, So-Young (Department of Physiology/Aging-associated Vascular Disease Research Center, College of Medicine, Yeungnam University) ;
  • Cho, Young-Je (School of Food Science & Biotechnology/Food & Bio-Industry Research Institute, Kyungpook National University)
  • 박소영 (영남대학교 의과대학 생리학교실) ;
  • 조영제 (경북대학교 식품공학부/식품생물산업연구소)
  • Received : 2015.02.24
  • Accepted : 2015.03.31
  • Published : 2015.06.30

Abstract

In this study, gastritis inhibitory substance was ethanol-extracted from Saururus chinensis in order to examine the effect as a part of natural bioactive substance research. In an oral administration experiment, S. chinensis was administered at doses of 0.25 g/kg B.W. to 2 g/kg B.W., resulting in stabilization at 1.5 g/kg B.W. and an $LD_{50}$ of 1.81 g/kg B.W. In a chronic toxicity experiment, 0.5 g/kg B.W. of S. chinensis was administered for 13 weeks, but toxicity was not observed. S. chinensis ethanol-extracts were administered at a concentration of 250 or 500 mg/kg B.W. before induction of gastritis. Gastrorrhagia, stomach edema, cytokine production, and cell damage were reduced in a concentration-dependent manner. Therefore, S. chinensis ethanol extracts inhibit cell damage by stress-induced hemorrhagic gastritis in a concentration-dependent manner via inhibition of cytokine expression.

Acknowledgement

Supported by : 지식경제부

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