Cell proliferation effect of brown marine algae extracts on Mouse Fibroblast

해조류 추출물이 섬유아세포의 증식에 미치는 영향

Ko, Ju-Young;Lee, Ji-Hyeok;Kim, Hyun-Soo;Kim, Hyung-Ho;Jeon, You-Jin

  • Received : 2015.07.06
  • Accepted : 2015.07.20
  • Published : 2015.06.30


We examined cell regeneration efficiency of brown marine algae living in Jeju coast for search of a novel therapeutic device with cutaneous wound healing materials. The five algae were collected and compared with epidermal growth factor (EGF) as a positive control in the assays of cell proliferation and cell migration of NIH3T3 fibroblast cells. Among the 80% methanol extracts of these brown algae, the two algal extracts from Ishige foliacea and Colpomenia bullosa showed the proliferative effects of the cells similar to the effect of EGF. Besides it was found that Colpomenia bullosa extract significantly enhanced cell migration of NIH3T3 cell. In the study, therefore, we confirmed that the Colpomenia bullosa extract improved proliferation of NIH3T3 cell and a potential candidate for cultaneous wound healing.


Brown marine algae;Epidermal growth factor;Cell proliferation;Fibroblast


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