Ameliorate Effect of Black Ginseng on HepG2 Cell transplanted in BALB/c Nude Mice

HepG2 세포주를 이식한 BALB/c Nude Mice에서 흑삼의 고형암 개선효과

  • Kang, Shin-Jyung (Dept. of Oriental Pharmaceutical Science, Joongbu University) ;
  • Han, Jung-Soon (Dept. of Alternative Medicine, Kyonggi University) ;
  • Kim, Ae-Jung (Dept. of Alternative Medicine, Kyonggi University)
  • 강신정 (중부대학교 한방제약과학과) ;
  • 한정순 (경기대학교 대체의학대학원) ;
  • 김애정 (경기대학교 대체의학대학원)
  • Received : 2015.01.29
  • Accepted : 2015.04.08
  • Published : 2015.04.30


The aim of this study was to examine the ameliorating effect of black ginseng on the growth of the HepG2 cell transplanted tumor in BALB/c nude mice. 27 male BALB/c nude mice (all six weeks old) were randomly divided into three groups: the control group, the first treatment group (HepG2300RG, using 300 mg/kg red ginseng), and the second treatment group (HepG2300BG, using 300 mg/kg black ginseng). The HepG2300BG in the HePG2 cells showed increased mean survival time than that of red ginseng group. The size and volume of the tumor in the 300BG group showed significant reduction compared to those of the HepG2300RG group (p<0.05). The body weight and liver weight of the HepG2300RG group was not significantly different with control and HepG2300BG group. The serum levels of ALT and AST in the HepG2300RG and HepG2300BG group were significantly lower than those of the control group. In conclusion, these results suggest that the black ginseng may have possible anti-tumor activities.


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