Analysis of Image for Liver Disease using Blood Test in the Ultrasound Fibroscan

Fibroscan에서의 혈액검사를 이용한 간질환의 영상분석

  • 이정현 (인제대학교 부산백병원) ;
  • 김동현 (부산가톨릭대학교 보건과학대학 방사선학과) ;
  • 김창수 (부산가톨릭대학교 보건과학대학 방사선학과)
  • Received : 2015.03.16
  • Accepted : 2015.05.29
  • Published : 2015.08.28


The liver fibrosis is a disease we often see in clinical medicine, and the persistence and repeatition of inflammation and necrosis of liver cells continue for several years, and it is proceeded to cirrhosis. So decrease of death rate and prevalence rate by complications of cirrhosis and hepatocellular carcinoma is main task of clinical medicine by protection of chronic liver ailment patients from proceeding to cirrhosis and hepatocellular carcinoma. So this study tried to represent the ultrasonic image, blood test, the relationship with liver stiffness of diffuse liver ailment patients as numbers. This study was performed with patients from whom the image was taken by ultrasonic and 141 people who were treated by fibroscan, the basic data for blood test was obtained from the test results at the time when ultrasonic image and liver fibroscan was performed. The statistical analysis was performed by One-way analysis of variance(ANOVA) to verify difference between groups. The value of liver stiffness was increased in the order of normal, chronic liver disease and cirrhosis. As a results, ALT and Albumin have no statistical difference between object groups, and there are statistical differences in the results of ultrasonic decoding at age, AST, ALP, Bilirubin, PLT, PT, and kPa, and they are statistically meaningful(p<0.005). And the value of liver stiffness of chronic liver ailment was presented only as over 12.5kPa in other study, but it was represented as numbers for quantitative diagnosis by presenting average kPa threshold value according to disease in this study. And by presenting relationship of diagnosed results, it is considered that it could be used as first tool to diagnose chronic liver ailment patients according to their disease.


Ultrasound;Liver Stiffness;Liver Function Test


  1. chun-Tao Wai, Joel K. Greenson, Robert J. Fontana, John D. Kalbfleisch, Jorge A. Marrer, Hari S. Conjeevaram, and Anna S. F. Lok, "A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C," Journal of hepatology, Vol.38, No.2, 2003.
  2. Sheila Sherlock, James Dooley, Diseases of the liver and biliary system 10th ed. Malden: Blackwell Science, pp.371-373, 1997.
  3. 김동욱, "간조직 생검으로 확진된 초기 간경변 환자들의 임상 및 검사실 성적들에 대한 5년 후 추적비교", 대한간학회지, 제8권, 제3호, pp.256-263, 2002.
  4. T. L. Wright, "Introduction to chronic hepatitis B infection," The american journal of gastroenterology, Vol.101, Suplemnet.1-6, 2006.
  5. F. Piccinino, E. Sagnelli, G. Pasquale, and G. Giusti, Complications following percutaneous liver biopsy, A multicentre retrospective study on 68,276 biopsies," Journal of hepatology, Vol.2, No.2, pp.165-173, 1986.
  6. D. B. McGill, J. Rakela, A. R. Zinsmeister, and B. J. Ott, "A 21-year experience with major hemorrhage after percutaneous liver biopsy," The american journal of gastroenterology, Vol.10, pp.1396-1400, 1990.
  7. 조윤정, 급성 간염 환자에서 $Fibroscan^{(R)}$을 이용한 Liver stiffness Measurement (LSM)의 변화, 가천대학교, 학위논문, 2010.
  8. Coco B, Oliveri F, Maina A. M, Ciccorossi P, Sacco R, Colombatto P, Colombatto F, Bonino, and M. R. Brnetto, "Transient elastography: a new surrogate marker of liver fibrosis influenced by major changes of transaminases," Journal of viral hepatitis, Vol.14, pp.360-369, 2007.
  9. L. Sandrin, B. Fourquet, and J. M. Hasquenoph, "A new non-invasive method for assessment of hepatic fibrosis," Official Journal of the World Federation for Ultrasound in Medicine and Biology, Vol.29, pp.1705-1713, 2003.
  10. 이미연, 초음파 검진에서 간질환의 유병률 및 발생요인에 관한 연구, 한서대학교 건강증진 대학원, 학위논문, 2007.
  11. 이홍섭, 만성 바이러스성 간염 환자에서 초음파 및 일반 혈액 검사를 이용한 대상 간경변증 예측, 아주대학교 대학원, 학위논문, 2011.
  12. N. Ganne-Carrie, M. Zio, V. de Ledinghen, C. Douvin, P. Marcellin, L. Castera, D. Dhumeaux, J. C. Trinchet, and M. Beauqrand, "Accuracy of liver stiffness measurement for the diagnosis of cirrhosis in patients with chronic liver disease," Journal of hepatology, Vol.44, No.6, 2006.
  13. L. Castera, J. Vergniol, J. Foucher, B. Le Bail, E. Chanteloup, M. Haaser, M. Darriet, P. Couzigou, and V. de Ledinghen, "Prospective comparison of transient elastography, FibroTest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C," The american journal of gastroenterology, Vol.12, 2005.
  14. A. Kettaneh, P. Marcellin, C. Douvin, R. Poupon, M. Ziol, M. Beaugrand, and V. de Lédinghen, "Features associated with success rate and performance of FibroScan measurements for the diagnosis of cirrhosis in HCV patients," Journal of hepatology, Vol.46, pp.628-634, 2007.
  15. U. Arena, F. Vizzutti, G. Corti, S. Ambu, C. Stasi, S. Bresci, S. Moscarella, V. Boddi, A. Petrarca, G. Laffi, F. Marra, and M. Pinzani, "Acute viral hepatitis increases liver stiffness values measured by transient elastography," Journal of hepatology, Vol.47, pp.380-384, 2008.