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Development of a LC-MS/MS method for simultaneous analysis of 20 antihistamines in dietary supplements

LC-MS/MS를 이용한 건강기능식품 내 항히스타민 20종 동시분석법 개발

  • Do, Jung-Ah (Advanced Analysis Team, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) ;
  • Kim, Jung Yeon (Advanced Analysis Team, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) ;
  • Choi, Ji Yeon (Advanced Analysis Team, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) ;
  • Lee, Ji Hyun (Advanced Analysis Team, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) ;
  • Kim, Hyung Joo (Advanced Analysis Team, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) ;
  • Noh, Eunyoung (Advanced Analysis Team, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) ;
  • Cho, So-Hyun (Advanced Analysis Team, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) ;
  • Yoon, Chang-Yong (Advanced Analysis Team, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) ;
  • Kim, Woo-Seong (Advanced Analysis Team, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
  • 도정아 (식품의약품안전처, 식품의약품안전평가원, 독성평가연구부, 첨단분석팀) ;
  • 김정연 (식품의약품안전처, 식품의약품안전평가원, 독성평가연구부, 첨단분석팀) ;
  • 최지연 (식품의약품안전처, 식품의약품안전평가원, 독성평가연구부, 첨단분석팀) ;
  • 이지현 (식품의약품안전처, 식품의약품안전평가원, 독성평가연구부, 첨단분석팀) ;
  • 김형주 (식품의약품안전처, 식품의약품안전평가원, 독성평가연구부, 첨단분석팀) ;
  • 노은영 (식품의약품안전처, 식품의약품안전평가원, 독성평가연구부, 첨단분석팀) ;
  • 조소현 (식품의약품안전처, 식품의약품안전평가원, 독성평가연구부, 첨단분석팀) ;
  • 윤창용 (식품의약품안전처, 식품의약품안전평가원, 독성평가연구부, 첨단분석팀) ;
  • 김우성 (식품의약품안전처, 식품의약품안전평가원, 독성평가연구부, 첨단분석팀)
  • Received : 2015.01.15
  • Accepted : 2015.03.06
  • Published : 2015.04.25

Abstract

Recently, the consumption of dietary supplements has increased because of people’s greater interest in health. Unfortunately, the sales of dietary supplements containing unauthorized substances such as drugs have also increased. We developed a rapid, accurate method for the simultaneous determination of antihistamines using liquid chromatography tandem mass spectrometry with a multiple reaction monitoring mode. The limit of detection (LOD) and limit of quantification (LOQ) of the instrument used in this method were in the ranges 0.0003-0.3 and 0.0009-0.6 µg mL−1, respectively. The linearity of the method was > 0.99. The precision levels of the method were 0.1-9.8% (intra-day) and 0.3-9.6% (inter-day), and the levels of accuracy of the method were 82.7-115.0% (intra-day) and 84.3-113.0% (inter-day). The mean of recovery of the method was in the range of 83.9-117.9% and the RSD of the stability was less than 5.9%.

Keywords

LC-MS/MS;antihistamines;dietary supplements;unauthorized substances;multiple reaction monitoring

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