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The analysis of endocrine distruptors in commercial cosmetics

유통 화장품 중 내분비계 장애물질 탐색 및 규명에 관한 연구

  • Koo, Heesoo (Busan Metropolitan City Institute of Health and Enviroment Department of Health Research Drug Analysis Division) ;
  • Na, Youngran (Busan Metropolitan City Institute of Health and Enviroment Department of Health Research Drug Analysis Division) ;
  • Lee, Seungju (Busan Metropolitan City Institute of Health and Enviroment Department of Health Research Drug Analysis Division) ;
  • Min, Sangkee (Busan Metropolitan City Institute of Health and Enviroment Department of Health Research Drug Analysis Division) ;
  • Kang, Jungmi (Busan Metropolitan City Institute of Health and Enviroment Department of Health Research Drug Analysis Division) ;
  • Jin, Sung Hyun (Busan Metropolitan City Institute of Health and Enviroment Department of Health Research Drug Analysis Division)
  • 구희수 (부산광역시 보건환경연구원 보건연구부 약품분석과) ;
  • 나영란 (부산광역시 보건환경연구원 보건연구부 약품분석과) ;
  • 이승주 (부산광역시 보건환경연구원 보건연구부 약품분석과) ;
  • 민상기 (부산광역시 보건환경연구원 보건연구부 약품분석과) ;
  • 강정미 (부산광역시 보건환경연구원 보건연구부 약품분석과) ;
  • 진성현 (부산광역시 보건환경연구원 보건연구부 약품분석과)
  • Received : 2015.03.24
  • Accepted : 2015.06.15
  • Published : 2015.06.25

Abstract

This study aims to identify the characteristics of phthalates (DMP, DEP, DBP, DEHA, BBP, DEHP, and DNOP) and heavy metals such as lead (Pb), cadmium (Cd), and mercury (Hg) in cosmetics and their containers. Phthalates and heavy metals may be endocrine distruptors. Sixty-five cosmetics were purchased from online and offline stores in Busan. This study developed a simultaneous method for the analysis of phthalates by GC-FID. The results showed that among the 65 cosmetics, DBP, DEHP, and DEP were detected at 20.0%, 7.7%, 1.5%, respectively. The amounts of DBP and DEHP detected in 18 samples were less than 100 μg/g, which satisfies the Regulations of Cosmetic Safety Standards in Korea. In order to detect phthalates in cosmetic containers, a dissolution test was conducted by extracting solutions, such as water, n-heptane, 20% ethanol, 50% ethanol and 4% acetic acid, which were prepared with different levels of pH, alcohol content, and fat content following the Korea Standards and Specifications for Utensils, Containers, and Packaging. The results showed that DMP, DBP, DEHA, BBP, DEHP, and DNOP were not detected, DEP was detected in plastics such as PE, PP, and others, when a 50% alcohol solvent was used. Phthalates may not be detected in cosmetic containers if they are not packaged with the above 20% alcohol constituent. We also analyzed the concentration of heavy metals, such as Pb, Cd, and Hg, by using ICP-OES and a mercury analyzer. The ranges of concentration were ND~2.71 μg/g for Pb, ND~0.31 μg/g for Cd, and ND~0.01 μg/g for Hg, which are below the regulated level.

Keywords

cosmetics;phthalate;heavy metal;endocrine disruptors;GC-FID

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