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Osteoarthritis Model Induced by Monosodium Iodoacetate: Good Model for Long-term Drug Efficacy Test

Monosodium Iodoacetate 유발 골관절염 모델: 장기적인 약물효능 평가에 적합한가?

  • Seo, Il-Bok (Department of Anatomy, College of Korean Medicine, Semyung University) ;
  • Park, Dong-Su (Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Semyung University)
  • 서일복 (세명대학교 한의과대학 해부학교실) ;
  • 박동수 (세명대학교 한의과대학 한방재활의학과교실)
  • Received : 2015.09.18
  • Accepted : 2015.10.04
  • Published : 2015.10.31

Abstract

Objectives This study was aimed to offer basic data in long term drug efficacy test using monosodium iodoacetate-induced osteoarthrits model. Methods Sixty male rats were divided into normal and osteoarthritic group. Rats of normal group were injected with 0.1 ml physiological saline, and rats of osteoarthritic group were inected with 0.1 ml monosodium iodoacetate (3 mg/ml) into each left and right knee joint cavities. Gross examination, proteoglycan contents and histopathological examination on the knee joint were performed at 10, 20, 40, and 60 days after injection. Results Grossly, degenerative changes at 10 days, desquamation at 40 days, and ulceration of articular cartilages at 60 days were observed. Proteoglycan contents in articular cartilages were decreased rapidly to 40 days, after than decreased gradually. Osteoarthritic scores were increased rapidly to 20 days, after than increased gradually to 60 days. Conclusions From above results, osteoarthritis model induced by a single intra-articular injection of monosodium iodoacetete is useful model for long term drug efficacy test.

Acknowledgement

Supported by : 세명대학교

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