Experimental Research of ZrO2/BCP/PCL Scaffold with Complex Pore Pattern for Bone Tissue Regeneration

골 조직 재생을 위한 복합 공극 패턴을 가진 ZrO2/BCP/PCL 인공지지체의 실험적 평가

  • Sa, Min-Woo (Dept. of Mechanical Engineering, Andong Nat'l Univ.) ;
  • Shim, Hae-Ri (Dept. of Mechanical Engineering, Andong Nat'l Univ.) ;
  • Kim, Jong Young (Dept. of Mechanical Engineering, Andong Nat'l Univ.)
  • 사민우 (안동대학교 기계공학과) ;
  • 심해리 (안동대학교 기계공학과) ;
  • 김종영 (안동대학교 기계공학과)
  • Received : 2015.06.25
  • Accepted : 2015.07.23
  • Published : 2015.11.01


Recently, synthetic biopolymers and bioceramics such as poly (${\varepsilon}$-caprolactone)(PCL), hydroxyapatite, tricalcium phosphate, biphasic calcium phosphate(BCP), and zirconia have been used as substrates to generate various tissues or organs in tissue engineering. Thus, the purpose of this study was the characterization of $ZrO_2$/BCP/PCL(ZBP) scaffold for bone tissue regeneration. Based on the result of single-line test, blended 3D ZBP scaffolds with fully interconnected pores and new complex pore pattern of $45^{\circ}+135^{\circ}$-type and staggered-type were successfully fabricated using a polymer deposition system. Furthermore, the effect of ZBP scaffold on mechanical property was analyzed. In addition, in vitro cell interaction of ZBP scaffold on MG63 cells was evaluated using a cell counting kit-8(CCK-8) assay.


Polymer Deposition System;Complex Pore Pattern;$ZrO_2$/BCP/PCL;Scaffold


Supported by : 안동대학교


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