Roles of Signaling Pathways in the Epithelial-Mesenchymal Transition in Cancer

  • Liu, Xia (Department of Pathology,The First Affiliated Hospital of Inner Mongolia Medical University) ;
  • Yun, Fen (Department of Pathology,The First Affiliated Hospital of Inner Mongolia Medical University) ;
  • Shi, Lin (Department of Pathology,The First Affiliated Hospital of Inner Mongolia Medical University) ;
  • Li, Zhe-Hai (The Third Affiliated Hospital of Inner Mongolia Medical University) ;
  • Luo, Nian-Rong (Physical Examination Center, the Inner Mongolia Autonomous Region People's Hospital) ;
  • Jia, Yong-Feng (Department of Pathology,The First Affiliated Hospital of Inner Mongolia Medical University)
  • Published : 2015.10.06


The epithelial-mesenchymal transition (EMT) is a cellular process though which an epithelial phenotype can be converted into a phenotype of mesenchymal cells. Under physiological conditions EMT is important for embryogenesis, organ development, wound repair and tissue remodeling. However, EMT may also be activated under pathologic conditions, especially in carcinogenesis and metastatic progression. Major signaling pathways involved in EMT include transforming growth factor ${\beta}(TGF-{\beta})$, Wnt, Notch, Hedgehog and other signaling pathways. These pathways are related to several transcription factors, including Twist, Smads and zinc finger proteins snail and slug. These interact with each other to provide crosstalk between the relevant signaling pathways. This review lays emphasis on studying the relationship between EMT and signaling pathways in carcinogenesis and metastatic progression.


EMT;signaling pathway;cancer


Supported by : National Natural Science Foundation of China


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