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Arsenic Exposure and Haematological Derangement in Cervical Cancer Cases in India

  • Kumar, Rahul (National Institute of Pharmaceutical Education & Research) ;
  • Trivedi, Vinita (Mahavir Cancer Sansthan & Research Centre) ;
  • Murti, Krishna (National Institute of Pharmaceutical Education & Research) ;
  • Dey, Akalanka (National Institute of Pharmaceutical Education & Research) ;
  • Singh, Jitendra Kumar (S.S.Hospital & Research Centre) ;
  • Nath, A (S.S.Hospital & Research Centre) ;
  • Das, P (Rajendra Memorial Research Institute of Medical Sciences)
  • Published : 2015.10.06

Abstract

Cervical cancer is the second most common gynecological malignancy worldwide. According to HPV Information Centre, Spain (Aug'2014), in India approximately 1,22,844 women are diagnosed with the disease every year and of them 67,477 die due to the disease. CaCx is said to be mediated by HPV but recent data published reveal the role of Oxidative Stress in different Cancers. Arsenic is also one of the agents for causing Oxidative Stress. Arsenic has been linked with different types of cancer. Arsenic is considered responsible for generation of free radicals and eventually for apoptosis. Early diagnosis of CaCx is presently a matter of concern and clinical presentation in advanced stages become difficult for complete clinical response. For determination of oxidative stress, Malondialdehyde (MDA) was taken as an identifier and arsenic estimation was performed with the help of Atomic Absorption Spectrometer (AAS). RBC count and Haemoglobin levels were performed according to standard protocol. MDA was in direct proportion with arsenic concentration and inversely proportional to RBC and Haemoglobin in CaCx patients. Arsenic is one of the major causative agents for oxidative stress and hence may be a risk factor leading to cancer including CaCx.

Keywords

Arsenic;LPO;RBC;WBC;cervical cancer

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