- Volume 16 Issue 15
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Anticancer Effects of Curcuma C20-Dialdehyde against Colon and Cervical Cancer Cell Lines
- Chaithongyot, Supattra (Department of Biochemistry, Faculty of Science, Khon Kaen University) ;
- Asgar, Ali (Program in Biological Science, Faculty of Science, Khon Kaen University) ;
- Senawong, Gulsiri (Department of Biochemistry, Faculty of Science, Khon Kaen University) ;
- Yowapuy, Anongnat (Department of Biochemistry, Faculty of Science, Khon Kaen University) ;
- Lattmann, Eric (Division of Pharmacy, School of Life and Health Sciences, Aston University) ;
- Sattayasai, Nison (Department of Biochemistry, Faculty of Science, Khon Kaen University) ;
- Senawong, Thanaset (Department of Biochemistry, Faculty of Science, Khon Kaen University)
- Published : 2015.10.06
Background: Recent attention on chemotherapeutic intervention against cancer has been focused on discovering and developing phytochemicals as anticancer agents with improved efficacy, low drug resistance and toxicity, low cost and limited adverse side effects. In this study, we investigated the effects of Curcuma C20-dialdehyde on growth, apoptosis and cell cycle arrest in colon and cervical cancer cell lines. Materials and Methods: Antiproliferative, apoptosis induction, and cell cycle arrest activities of Curcuma C20-dialdehyde were determined by WST cell proliferation assay, flow cytometric Alexa fluor 488-annexin V/propidium iodide (PI) staining and PI staining, respectively. Results: Curcuma C20 dialdehyde suppressed the proliferation of HCT116, HT29 and HeLa cells, with IC50 values of
Antiproliferative activity;apoptosis;Curcuma C20-dialdehyde;cell cycle arrest;cervical;colon cancer
Supported by : National Research Council of Thailand
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