- Volume 16 Issue 15
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Creatine Kinase (CK)-MB-to-Total-CK Ratio: a Laboratory Indicator for Primary Cancer Screening
- Chang, Chih-Chun (Department of Clinical Pathology, Far Eastern Memorial Hospital) ;
- Liou, Ching-Biau (Department of Clinical Pathology, Far Eastern Memorial Hospital) ;
- Su, Ming-Jang (Department of Clinical Pathology, Far Eastern Memorial Hospital) ;
- Lee, Yi-Chen (Department of Clinical Pathology, Far Eastern Memorial Hospital) ;
- Liang, Chai-Ting (Department of Clinical Pathology, Far Eastern Memorial Hospital) ;
- Ho, Jung-Li (Department of Clinical Pathology, Far Eastern Memorial Hospital) ;
- Tsai, Huang-Wen (Division of General Surgery, Department of Surgery, Far Eastern Memorial Hospital) ;
- Yen, Tzung-Hai (Division of Nephrology and Clinical Toxicology, Chang Gung Memorial Hospital, Lin-Kou Medical Center) ;
- Chu, Fang-Yeh (Department of Clinical Pathology, Far Eastern Memorial Hospital)
- Published : 2015.10.06
Background: For the determination of creatine kinase (CK)-MB, the immunoinhibition method is utilized most commonly. However, the estimated CK-MB activity may be influenced by the presence of CK isoenzymes in some conditions like cancer. Thus, a CK-MB-to-total-CK ratio more than 1.0 could be found in such a situation. The study aimed to explore the relationship of cancer to high CK-MB-to-total-CK ratio. Materials and Methods: From January 2011 to December 2014, laboratory data on all CK-MB and total CK test requests were extracted at Far Eastern Memorial Hospital (88,415 requests). Patients with a CK-MB-to-total-CK ratio more than 1.0 were registered in this study. Clinical data including tumor location, tumor TNM stage and metastatic status were also collected. Results: A total of 846 patients were identified with a CK-MB-to-total-CK ratio more than 1.0. Of these, 339 (40.1%) were diagnosed with malignancies. The mean CK-MB-to-total-CK ratio was significantly higher in malignancy than in non-malignancy (
Creatine kinase;cancer;tumor biomarker;CK-MB-to-total-CK ratio
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