- Volume 16 Issue 15
DOI QR Code
Tumors Involving Skin, Soft Tissue and Skeletal Muscle: Benign, Primary Malignant or Metastatic?
- Hsieh, Chi-Ying (Division of Plastic and Reconstructive Surgery in the Instituition, Far Eastern Memorial Hospital) ;
- Tsai, Huang-Wen (Division of General Surgery, Department of Surgery, Far Eastern Memorial Hospital) ;
- Chang, Chih-Chun (Department of Clinical Pathology, Far Eastern Memorial Hospital) ;
- Lin, Tsuo-Wu (Division of Plastic and Reconstructive Surgery in the Instituition, Far Eastern Memorial Hospital) ;
- Chang, Ke-Chung (Division of Plastic and Reconstructive Surgery in the Instituition, Far Eastern Memorial Hospital) ;
- Chen, Yo-Shen (Division of Plastic and Reconstructive Surgery in the Instituition, Far Eastern Memorial Hospital)
- Published : 2015.10.06
Background: Metastatic cancer with invasion of skin, soft tissue and skeletal muscle is not common. Examples presenting as soft tissue masses could sometimes lead to misdiagnosis with delayed or inappropriate management. The purpose of current study was to investigate clinical characteristics in the involvement of metastatic cancer. Materials and Methods: A total of 1,097 patients complaining of skin or soft tissue masses and/or lesions were retrospectively reviewed from January 2012 to June 2013. Tumors involving skin, soft tissue and skeletal muscle of head and neck, chest wall, abdominal wall, pelvic region, back, upper and lower extremities were included in the study. Results: Fifty-seven (5.2%) patients were recognized as having malignancies on histopathological examination. The most common involvement of malignancy was basal cell carcinoma, followed by cutaneous squamous cell carcinoma, sarcoma and melanoma. The most common anatomical location in skin and soft tissue malignancies was head and neck (52.6% of the malignancies). Four (0.36%) of the malignant group were identified as metastatic cancer with the primary cancer source from lung, liver and tonsil and the most common site was upper extremities. One of them unexpectedly expired during the operation of metastatic tumor excision at the scalp. Conclusions: Discrimination between benign and malignant soft tissue tumors is crucial. Performance of imaging study could assist in the differential diagnosis and the pre-operative risk evaluation of metastatic tumors involving skin, soft tissue and skeletal muscle.
Skeletal muscle tumor;skin tumor;soft tissue metastasis;subcutaneous tumor
- Capell BC, Tlougan BE, Or low SJ (2009). From the rarest to the most common: insights from progeroid syndromes into skin cancer and aging. J Invest Dermatol, 129, 2340-50. https://doi.org/10.1038/jid.2009.103
- Hasegawa S, Sakurai Y, Imazu H, et al (2000). Metastasis to the forearm skeletal muscle from an adenocarcinoma of the colon: report of a case. Surg Today, 30, 1118-23. https://doi.org/10.1007/s005950070013
- Haygood TM, Wong J, Lin JC, et al (2012). Skeletal muscle metastases: a three-part study of a not-so-rare entity. Skeletal Radiol, 41, 899-909. https://doi.org/10.1007/s00256-011-1319-8
- Hussein MR (2010). Skin metastasis: a pathologist's perspective. J Cutan Pathol, 37, 1-20.
- Kaur R, Kwatra KS, Masih K, Calton N. (2014). Metastatic squamous cell carcinoma of the lung masquerading as a soft tissue tumor. J Cytol, 31, 117-8. https://doi.org/10.4103/0970-9371.138693
- Khaw P, Ball D, Duchesne G (2001). Carcinoid tumor of the orbital muscle: a rare occurrence. Australas Radiol, 45, 179-81. https://doi.org/10.1046/j.1440-1673.2001.00899.x
- Koike Y, Hatori M, Kokubun S (2005). Skeletal muscle metastasis secondary to cancer - a report of seven cases. Ups J Med Sci, 110, 75-83. https://doi.org/10.3109/2000-1967-183
- Lin JS, Eder M, Weinmann S (2011). Behavioral counseling to prevent skin cancer: a systematic review for the U.S. Preventive Services Task Force. Ann Intern Med, 154, 190-201. https://doi.org/10.7326/0003-4819-154-3-201102010-00009
- Lohiya V, Lohiya S, Windsor K (2013). A large thigh mass: a blood clot or a rare skeletal muscle metastasis from renal cell carcinoma. Springerplus, 2, 399. https://doi.org/10.1186/2193-1801-2-399
- Luba MC, Bangs SA, Mohler AM, et al (2003). Common benign skin tumors. Am Fam Physician, 67, 729-38.
- Molina-Garrido MJ, Guillen-Ponce C (2011). Muscle metastasis of carcinoma. Clin Transl Oncol, 13, 98-101. https://doi.org/10.1007/s12094-011-0625-x
- Nabeyama R, Tanaka K, Matsuda S, Iwamoto Y (2001). Multiple intramuscular metastases 15 years after radical nephrectomy in a patient with stage IV renal cell carcinoma. J Orthop Sci, 6, 189-92. https://doi.org/10.1007/s007760100070
- Nava G, Greer K, Patterson J, Lin KY. (2009). Metastatic cutaneous breast carcinoma: A case report and review of the literature. Can J Plast Surg, 17, 25-7.
- Plaza JA, Perez-Montiel D, Mayerson J, et al (2008). Metastases to soft tissue: a review of 118 cases over a 30-year period. Cancer, 112, 193-203. https://doi.org/10.1002/cncr.23151
- Qiu DS, Xu LY, Shames S (2014). The value of 18F-fluorodeoxyglucose positron emission tomography combined with computed tomography in the detection and characterization of soft tissue metastasis. Mol Clin Oncol, 2, 761-6.
- Rajabpour FV, Raoofian R, Youssefian L, et al (2014). BMI1 and TWIST1 Downregulated mRNA Expression in Basal Cell Carcinoma. Asian Pac J Cancer Prev, 15, 3797-800. https://doi.org/10.7314/APJCP.2014.15.8.3797
- Surov A, Hainz M, Holzhausen HJ, et al (2010). Skeletal muscle metastases: primary tumours, prevalence, and radiological features. Eur Radiol, 20, 649-58. https://doi.org/10.1007/s00330-009-1577-1
- Uysal-Sonmez O, Tanriverdi O, Esbah O, et al (2013). Multicenter evaluation of patients with cutaneous malignant melanoma in Turkey: MELAS study. Asian Pac J Cancer Prev, 14, 533-7. https://doi.org/10.7314/APJCP.2013.14.1.533