Outcome of Palliative and Radical Radiotherapy in Patients with Oral Squamous Cell Carcinoma - a Retrospective Study

Rai, Narendra Prakash;Divakar, Darshan Devang;Al Kheraif, Abdulaziz Abdullah;Ramakrishnaiah, Ravikumar;Mustafa, Shabil Mohamed;Durgesh, BH;Basavarajappa, Santhosh;Khan, Aftab Ahmed

  • Published : 2015.11.04


Background: The treatment selection for the oral squamous cell carcinoma remains controversial. Radiation therapy or surgical excision of the lesion can be applied as the sole treatment or it can be used in combination with other treatment modalities. Radiotherapy is considered to be the safest of all the treatment modalities and can be used in several situations for oral and oropharyngeal cancers. The aim of this study was to evaluate the survival outcome differences in patients treated with radical and palliative radiotherapy as the primary treatment modality. Materials and Methods: The study included a total of 47 patients with oral cancer reporting to our hospital between years 2009 to 2010. The age group for the selected patients was more than 65 years, treated with radical and palliative radiotherapy with no prior surgical interventions. Patients were evaluated till Dec 2013 for overall survival time. Results: Twenty nine patients were treated with radical radiotherapy as main stay of treatment, out of which 21 died during the follow up time with median survival of $352{\pm}281.7$ days with 8 patients alive. All the 16 patients were dead who received palliative radiotherapy with a median survival time of $112{\pm}144.0$ days. Conclusions: This retrospective study showed improved overall survival time, loco regional control rates and reduced morbidity in patients treated with radical radiotherapy when compared to patients treated with palliative radiotherapy.


Long term survival;oral cancer;palliative radiotherapy;radical radiotherapy


  1. Abbasi M M, Esfahlan RJ, Monfaredan A, et al (2014). Oral and IV dosages of doxorubicin-methotrexate loadednanoparticles inhibit progression of oral cancer by downregulation of matrix methaloproteinase 2 expression in Vivo. Asian Pac J Cancer Prev, 15, 10705-11.
  2. Al-Attas S A, Ibrahim S S, Amer H A, Darwish Z E, Hassan M H (2014). Prevalence of potentially malignant oral mucosal lesions among tobacco users in jeddah, Saudi Arabia. Asian Pac J Cancer Prev, 15, 757-62.
  3. Fonseca RJ (2000) Oral and Maxillofacial Surgery. Surgical Pathology 1st edition. Philadelphia, Pennsylvania; Saunders publication.
  4. Indian Council of Medical Research (2001). ICMR Bulletin. National cancer registry of the indian council for medical research annual report, New Delhi, India.
  5. Krishnan R, Thayalan DK, Padmanaban R, et al (2014). Association of serum and salivary tumor necrosis factor-${\alpha}$ with histological grading in oral cancer and its role in differentiating premalignant and malignant oral disease. Asian Pac J Cancer Prev, 15, 7141-8.
  6. Kumar S, Muniyandi M (2015). Tobacco Use and oral leukoplakia: cross-sectional study among the gond tribe in madhya pradesh. Asian Pac J Cancer Prev, 16, 1515-8.
  7. Mohanti BK, Umapathy H, Bahadur S, Thakar A, Pathy S (2004). Short course palliative radiotherapy of 20 Gy in 5 fractions for advanced and incurable head and neck cancer: AIIMS study. Radiother Oncol, 71, 275-80.
  8. Moore MA, Tsuda H (2002). Smoking-related research in the asian-pacific countries. Asian Pac J Cancer Prev, 3, 291-304.
  9. Moore MA (2009). Diverse influences of dietary factors on cancer in asia. Asian Pac J Cancer Prev, 10, 981-6.
  10. Moore MA (2013). Overview of cancer registration research in the Asian Pacific from 2008-2013. Asian Pac J Cancer Prev, 14, 4461-84.
  11. Shishodia NP, Divakar DD, Al Kheraif AA, et al (2015). End stage palliative care of head and neck cancer: a case study. Asian Pac J Cancer Prev, 16, 1255-8.
  12. Patel SS, Shah KA, Shah MJ, Kothari KC, Rawal RM (2014). Cancer stem cells and stemness markers in oral squamous cell carcinomas. Asian Pac J Cancer Prev, 15, 8549-8556.
  13. Ryan J. Burri, Nancy Y. Lee (2009). Concurrent chemotherapy and radiotherapy for head and neck cancer. Expert Rev Anticancer Ther, 9, 293-302.

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