# Development of SiPM-based Small-animal PET

• Lee, Jin Hyung ;
• Lee, Seung-Jae ;
• Chung, Yong Hyun
• Accepted : 2015.10.25
• Published : 2015.10.31
• 26 8

#### Abstract

A decreased number of readout method is investigated to provide precise pixel information for small-animal positron emission tomography (PET). Small-animal PET consists of eight modules, and each module is composed of a $6{\times}6$ array of $2{\times}2{\times}20mm^3$ lutetium yttrium orthosilicate (LYSO) crystals optically coupled to a $4{\times}4$ array of $3{\times}3mm^2$ silicon photomultipliers (SiPMs). The number of readout channels is reduced by one-quarter that of the conventional method by applying a simplified row and column matrix algorithm. The performance of the PET system and detector module was evaluated with Geant4 Application for Emission Tomography (GATE) 6.1 and DETECT2000 simulations. In the results, all pixels of the $6{\times}6$ LYSO array were decoded well, and the spatial resolution and sensitivity, respectively, of the PET system were 1.75 mm and 4.6% (@ center of field of view, energy window: 350-650 keV).

#### Keywords

SiPM;Small-animal PET;Algorithm;GATE simulation;DETECT2000 simulation

#### References

1. R. Yao et al., "Small-animal PET: what is it, and why do we need it?," J. Nucl. Med. Techno, Vol. 40, pp. 157-165, May 2012. https://doi.org/10.2967/jnmt.111.098632
2. S. R. Cherry et al., Physics in Nuclear Medicine 3rd ed. (Saunders), 2003
3. S. R. Cherry et al., "MicroPET: a high resolution PET scanner for imaging small animals," IEEE Trans. Nucl. Sci. Vol. 44, no. 3, pp. 1161-1166, Jun 1997. https://doi.org/10.1109/23.596981
4. Y. Wang et al., "Performance evaluation of the GE Healthcare eXplore VISTA dual-ring small-animal PET scanner," J. Nucl. Med. Vol. 47, no. 11, pp. 1891-1900, November 2006.
5. S. Surti et al., "Design evaluation of A-PET: a high sensitivity animal PET camera," IEEE Trans.Nucl. Sci. Vol. 50, no. 5, pp. 1357-1363, October 2003. https://doi.org/10.1109/TNS.2003.817950
6. K. Ziemonsa et al., "The ClearPET$^{TM}$ project: development of a 2nd generation high-performance small animal PET scanner," Nucl. Instrum. Methods Phys. Res. A Vol. 537, no. 1-2, pp. 307-311, January 2005. https://doi.org/10.1016/j.nima.2004.08.032
7. H.O. Anger et al., "Scintillation camera" Rev. Sci. Instrum. 29, 27, 1958. https://doi.org/10.1063/1.1715998
8. E. Roncali et al., "Application of silicon photomultipliers to positron emission tomography," Annals of Biomedical Engineering, Vol. 39, No. 4, pp. 1358-1377, April 2011. https://doi.org/10.1007/s10439-011-0266-9
9. KETEK SIPM TECHNOLOGY.
10. M. Ito et al., "Design and simulation of a novel method for determining depth-of-interaction in a PET scintillation crystal array using a single-ended readout by a multi-anode PMT," Nucl. Instrum. Methods Phys. Res. A Vol. 743, pp. 30-38, 2014. https://doi.org/10.1016/j.nima.2014.01.010
11. S. Jan et al., "GATE: a simulation toolkit for PET and SPECT," Phys. Med. Biol. Vol. 49, pp. 4543-4561, September 2004. https://doi.org/10.1088/0031-9155/49/19/007
12. F. Cayouette et al., "DETECT2000: Monte-Carlo simulator for the computer aided design of photon sensing devices," SPIE 4833, Applications of Photonic Technology 5, 69, February 2003.

#### Acknowledgement

Supported by : National Research Foundation (NRF)