Inhibitory effect of mushrooms extract on TNF-α/INF-γ induced-cytokine in human keratinocytes, HaCaT

버섯류 추출물의 피부각질세포(HaCaTcell) 내 염증성 사이토카인 억제효과

  • Choi, Eun-Ju (Division of Sport Science, College of Science and Technology, Konkuk University) ;
  • Kim, Eun-Kyung (Division of Food Bioscience, College of Biomedical and Health Sciences, Konkuk University) ;
  • Ji, Yong-Seok (Department of Physical Education, Cheongju University) ;
  • Lee, Chang-Jin (Division of Sport Science, College of Science and Technology, Konkuk University)
  • 최은주 (건국대학교 과학기술대학 스포츠과학부) ;
  • 김은경 (건국대학교 의료생명대학 식품생명과학부) ;
  • 지용석 (청주대학교 체육교육학과) ;
  • 이창진 (건국대학교 과학기술대학 스포츠과학부)
  • Received : 2015.08.04
  • Accepted : 2015.10.02
  • Published : 2015.09.30


Mushroom is known for anti-inflammatory and anti-oxidative potential. This study provides evidence that the inhibitory effect of mushroom on the expression of pro-inflammatory cytokines in human keratinocytes, HaCaT cells. To define the underlying mechanisms of action, tumor necrosis factor${\alpha}$/$IFN{\gamma}$-activated human keratinocytes model was used. Mushroom significantly inhibited the expression of cytokines in HaCaT cells. Taken together, the results demonstrate that mushroom inhibited inflammtion, suggesting that mushroom (DW extract: Grifola frondosa Cordyceps militaris), (Ethanol extract: Ganoderma lucidum, Lentinus edodes, Cordyceps militaris, Flammulina velutipes) might be a candidate for the treatment of skin inflammation.


Cytokine;HaCaT cell;Inflammation;Mushroom;TNF-${\alpha}$


Supported by : 농촌진흥청


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