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The effect of the mushrooms extract on the PSA expression in prostate cancer cells

버섯류 추출물이 전립선 암 세포 내 PSA 발현에 미치는 영향

  • Kim, Eun-Kyung (Division of Food Bio Science, Konkuk University) ;
  • Tang, Yujiao (Division of Food Bio Science, Konkuk University) ;
  • Choi, Heeri (Division of Sport Science, Konkuk University) ;
  • Choi, Eun-Ju (Division of Sport Science, Konkuk University)
  • 김은경 (건국대학교 식품생명과학부) ;
  • 당옥교 (건국대학교 식품생명과학부) ;
  • 최희리 (건국대학교 스포츠과학부) ;
  • 최은주 (건국대학교 스포츠과학부)
  • Received : 2015.08.10
  • Accepted : 2015.10.02
  • Published : 2015.09.30

Abstract

Mushroom have long been valued as highly nutritious and tasty foods in many societies throughout the world. It is known for biological activities including anti-inflammatory and anti-oxidative potential. However little is known about anti-cancer property. In this study, we investigated the anti-prostate cancer activity of mushrooms. For that, eight kinds of mushrooms such as, T. matsutake, S. crispa, G. lucidum-US, G. lucidum-AS, C. cardinalis-BR, G. frondosa, P. linteus, U. esculenta were extracted with hot water. Among them, three kinds of mushrooms including T. matsutake, G. lucidum-US and C. militaris-BR extracts inhibited prostate specific antigen (PSA) expression in prostate cancer cell, LNCaP. These results demonstrate that some of mushrooms inhibited PSA expression suggesting that the mushrooms might be a candidate for the treatment of prostate cancer.

Keywords

LNCaP;Mushroom;Prostate cancer;PSA

Acknowledgement

Supported by : 농촌진흥청, 연구재단

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