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굴 효소 가수분해물과 분자량 분획물의 섬유아세포에 대한 주름 개선 효과

김현아;박시향;이수선;최영준
Kim, Hyeon-Ah;Park, Si-Hyang;Lee, Su-Seon;Choi, Yeung Joon

  • 투고 : 2015.07.09
  • 심사 : 2015.08.06
  • 발행 : 2015.11.30

초록

해양생물 유래 피부건강 기능성의 소재를 발굴할 목적으로 굴 단백질을 Protamex와 Neutrase로 가수분해 한 후 생성된 굴 가수분해물 펩타이드의 주름 개선 효과를 조사하였다. 굴 가수분해물은 약 7.9%의 유리아미노산을 포함하며 urea, taurine, alanine, glycine 등의 아미노산의 함량이 높았다. 굴 가수분해물은 collagenase 저해 활성을 가지고 있었고, 피부세포인 CCD986sk에 대한 독성은 없었다. 분획물의 수율은 1,000 Da 미만이 40%였으며, 5,000 Da 미만이 60.4%를 차지하였다. 1,000~3,000 Da인 분획물이 항산화 활성, procollagen의 생성능 및 MMP-1 효소 저해 활성이 가장 높았다. 굴 가수분해물과 5,000 Da 미만의 분획물은 주름 개선을 위한 피부건강 기능성 소재로서 화장품 등의 제품에 응용 가능함을 확인하였다.

키워드

oyster;radical;procollagen;collagenase

참고문헌

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과제정보

연구 과제 주관 기관 : 해양수산부