DOI QR코드

DOI QR Code

Development of Pressure Sensor for Identifying Guinea Pig's Large Intestinal Motility Caused by Drug

약물 투여에 따른 기니피그 대장 운동 측정을 위한 압력센서 개발

Park, Jae-Soon;Park, Jung-Ho;Kim, Eung-Bo;Cho, Sung-Hwan;Jang, Su-Jeong;Joung, Yeun-Ho
박재순;박정호;김응보;조성환;장수정;정연호

  • Received : 2015.09.21
  • Accepted : 2015.12.07
  • Published : 2016.01.01

Abstract

In this paper, in order to quantify the peristalsis occurrence in a guinea pig's large intestine, a miniaturized air-gap capacitive pressure sensor was fabricated through micro-electro-mechanical system (MEMS). The proposed pressure sensor is a two-layered biocompatible polyimide substrate consisting of an air-gap capacitive plates between the substrates. The proposed pressure sensor was designed with a careful consideration of the structure and motility mechanism of the guinea pig's large intestine. Artificial pellets were mounted on a prototype pressure sensor to provide some redundancies in the form of size and shape of the guinea pig feces. Capacitance of a prototype sensor was recorded to be 2.5 ~ 3 pF. This capacitance value was later converted to count value using a lab fabricated data conversion system. Sensitivity of the pressure sensor was recorded to be below 1 mmHg per atmospheric pressure. During in vivo testing, artificial peristalsis caused by drug injection was measured by inserting the prototype pressure sensor into the guinea pig's large intestine and pressure data obtained due to artificial peristalsis was graphed using a labview program. The proposed pressure sensor could measure the pressure changes in the proximal, medial, and distal parts of the large intestine. The results of the experiment confirmed that pressure changes of guinea pig's large intestine was proportional to the degree of drug injection.

Keywords

Pressure sensor;MEMS;Polyimide;Artificial pellet;Intestinal motility

References

  1. S. J. Myung, T. H. Lee, K. C. Huh, S. C. Choi, and C. I. Sohn, The Korean Society of Gastroenterology, 55, 316 (2010). [DOI: http://dx.doi.org/10.4166/kjg.2010.55.5.316] https://doi.org/10.4166/kjg.2010.55.5.316
  2. J. W. Cho, National Health Insurance Service, 3 (2014).
  3. C. Y. Chen, J. R. Chen, M. D. Ke, C. H. Huang, Y. H. Hsueh, and C. D. Kuo, IEEE APCCAS, 450 (2010).
  4. J. H. Lim, H. S. Kim, E. J. Choi, C. K. Shim, and H. J. Park, The Korean Society of Neurogastroenterology and Motility, 14, 7 (2008).
  5. J. W. Arkwright, N. G. Blenman, I. D. Underhill, S. A. Maunder, N. J. Spencer, M. Costa, Simon J. Brookes, M. M. Szczesniak, and P. G. Dinning, IEEE Sensors Journal, 12, 113 (2012). [DOI: http://dx.doi.org/10.1109/JSEN.2011.2123883] https://doi.org/10.1109/JSEN.2011.2123883
  6. H. S. Kim, E. J. Choi, and H. Park, Neurogastroenterol Motil, 20, 169 (2008). [DOI: http://dx.doi.org/10.1111/j.1365-2982.2008.01128.x]
  7. M. Dokmeci and K. Najafi, Journal of Microelectromechanical Systems, 10, 197 (2001). [DOI: http://dx.doi.org/10.1109/84.925735] https://doi.org/10.1109/84.925735
  8. J. T. Kim, S. I. Kim, and Y. H. Joung, J. Korean Inst. Electr. Electron. Mater. Eng., 26, 669 (2013).

Acknowledgement

Supported by : 산업통상자원부