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Immunohistochemical Evaluation of Glucose Transporter Type 1 in Epithelial Dysplasia and Oral Squamous Cell Carcinoma

  • Pereira, Karuza Maria Alves ;
  • Feitosa, Sthefane Gomes ;
  • Lima, Ana Thayssa Tomaz ;
  • Luna, Ealber Carvalho Macedo ;
  • Cavalcante, Roberta Barroso ;
  • Lima, Kenio Costa de ;
  • Chaves, Filipe Nobre ;
  • Costa, Fabio Wildson Gurgel
  • Published : 2016.02.05

Abstract

Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity and some of these have been documented in association or preceded by oral epithelial dysplasia (OED). Aggressive cancers with fast growth have demonstrated overexpression of some glucose transporters (GLUTs). Thus, the aim of this study was to analyze the immunohistochemical expression of the glucose transporter, GLUT-1, in OEDs and OSCCs, seeking to better elucidate the biological behavior of neoplasias. Fifteen cases were selected this research of both lesions. Five areas were analyzed from each case by counting the percentage of positive cells at 400x magnification. Immunoreactivity of GLUT-1 was observed in 100% of the samples ranging from 54.2% to 86.2% for the OSCC and 73.9% to 97.4% for the OED. Statistical test revealed that there was greater overexpression of GLUT-1 in OED than the OSCC (p=0.01). It is believed the high expression of GLUT-1 may reflect the involvement of GLUT-1 in early stages of oral carcinogenesis.

Keywords

Oral squamous cell carcinoma;oral epithelaial dysplaisa;GLUT;immunohistochemistry

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  1. Glycolysis-related protein expression in thyroid cancer vol.39, pp.3, 2017, https://doi.org/10.1177/1010428317695922

Acknowledgement

Supported by : Fundacao Cearense de Apoio ao Desenvolvimento Cientifico e Tecnologico