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Comparative Study of Dermatoscopic and Histopathologic Results in Facial Basal Cell Carcinoma and Melanocytic Nevi

  • Amirnia, Mehdi ;
  • Ranjkesh, Mohammad-Reza ;
  • Azimpouran, Mahzad ;
  • Karkon-Shayan, Farid ;
  • Alikhah, Hossein ;
  • Jafari-Asl, Mohammadali ;
  • Piri, Reza ;
  • Naghavi-Behzad, Mohammad
  • Published : 2016.02.05

Abstract

Background: Dermatoscopy can be applied to diagnose pigmented skin lesions. The aim of the present study was to compare dermatoscopic and histopathologic results in basal cell carcinoma (BCC) and melanocytic nevus of theface. Materials and Methods: In an analytical-descriptive study, 61 patients suspected of BCC or melanocytic nevi of face were randomly selected. The skin lesions of patients were evaluated with dermatoscopic method from February 2012 to February 2014 and results were compared with pathological features of samples. Results: In this study, mean age of patients was $49.5{\pm}18.9$. Some 25 (41%) were men and 36 (59%) were women. In 27 cases (44.3%) there was diagnosis of melanocytic nevus, in 28 cases (45.9%) diagnosis of BCC, and in 3 cases (4.9%) there was mixed diagnosis. The relationship between patients' gender and dermatoscopic diagnosis of the patients was statistically significant (P=0.001). For BCC the sensitivity and specificity of dermatoscopic method were 100% and 97% respectively and for melanocytic nevi 96.4% and 97%. Conclusions: Dermatoscopic study not only can be helpful in improving clinical diagnosis while guiding missed malignant lesions to pathologic evaluations, but also could be useful in evaluating further suspicious or recurrent cases.

Keywords

Dermatoscopy;basal cell carcinoma;melanocytic nevi;histopathology

References

  1. Morales-Callaghan A, Castrodeza-Sanz J, Martinez-Garcia G, et al (2008). Correlation between clinical, dermatoscopic, and histopathologic variables in atypical melanocytic nevi. Actas Dermo-Sifiliograficas, 99, 380-9. https://doi.org/10.1016/S0001-7310(08)74697-0
  2. Mortazavi H, Baharvand M, Mehdipour M (2014). Oral potentially malignant disorders: an overview of more than 20 entities. J Res, Dental Clinics, Dental Prospects, 8, 6.
  3. Rezze GG, Sa BCSd, Neves RI (2006). Dermoscopy: the pattern analysis. Anais Brasileiros de Dermatologia, 81, 261-8. https://doi.org/10.1590/S0365-05962006000300009
  4. Rosendahl C, Cameron A, McColl I, et al (2012). Dermatoscopy in routine practice:'Chaos and clues'. Australian Family Physician, 41, 482.
  5. Scalvenzi M, Lembo S, Francia MG, et al (2008). Dermoscopic patterns of superficial basal cell carcinoma. International J Dermatol, 47, 1015-8. https://doi.org/10.1111/j.1365-4632.2008.03731.x
  6. Soyer HP, Argenziano G, Hofmann-Wellenhof R, et al (2011). Dermoscopy: the essentials, Elsevier Health Sciences.
  7. Stolz W, Bilek P, Landthaler M, et al (1989). Skin surface microscopy. Lancet, 334, 864-5.
  8. Tang L, Zhang W, Su B, et al (2013). Long noncoding RNA HOTAIR is associated with motility, invasion, and metastatic potential of metastatic melanoma. Bio Med Res Int, 2013.
  9. Tschandl P, Rosendahl C, Kittler H (2015). Dermatoscopy of flat pigmented facial lesions. Je Eur Academy Dermatol Venereol, 29, 120-7. https://doi.org/10.1111/jdv.12483
  10. Micali G, Lacarrubba F, Massimino D, et al (2011). Dermatoscopy: alternative uses in daily clinical practice. J Am Acad Dermatol, 64, 1135-46. https://doi.org/10.1016/j.jaad.2010.03.010
  11. Miteva M, Tosti A (2012). Hair and scalp dermatoscopy. J Am Acad Dermatol, 67, 1040-8. https://doi.org/10.1016/j.jaad.2012.02.013
  12. Boldrick JC, Layton CJ, Nguyen J, et al (2007). Evaluation of digital dermoscopy in a pigmented lesion clinic: clinician versus computer assessment of malignancy risk. J Am Acad Dermatol, 56, 417-21. https://doi.org/10.1016/j.jaad.2006.08.033
  13. Celebi ME, Iyatomi H, Schaefer G, et al (2009). Lesion border detection in dermoscopy images. Computerized Med Imag Graphics, 33, 148-53. https://doi.org/10.1016/j.compmedimag.2008.11.002
  14. de Giorgi V, Sestini S, Massi D, et al (2006). Dermoscopy for “true” amelanotic melanoma: a clinical dermoscopicpathologic case study. J Am Acad Dermatol, 54, 341-4. https://doi.org/10.1016/j.jaad.2005.04.040
  15. Demirtasoglu M, Ilknur T, Lebe B, et al (2006). Evaluation of dermoscopic and histopathologic features and their correlations in pigmented basal cell carcinomas. J Eur Acad Dermatol Venereol, 20, 916-20. https://doi.org/10.1111/j.1468-3083.2006.01620.x
  16. Di Cesare A, Sera F, Gulia A, et al (2012). The spectrum of dermatoscopic patterns in blue nevi. J Am Acad Dermatol, 67, 199-205. https://doi.org/10.1016/j.jaad.2011.08.018
  17. Fakhrjou A, Dastranj-Tabrizi A, Ghojazadeh M, et al (2013). Diagnostic Value of Protein Ki67 (MIB-1) in Atypical Pap Smears of Postmenopausal Women. Asian Pac J Cancer Prev, 14, 4815-8. https://doi.org/10.7314/APJCP.2013.14.8.4815
  18. Fargnoli MC, Kostaki D, Piccioni A, et al (2012). Dermoscopy in the diagnosis and management of non-melanoma skin cancers. Eur J Dermatol, 22, 456-63.
  19. Fracaroli TS, Lavorato FG, Maceira JP, et al (2013). Parallel ridge pattern on dermoscopy: observation in non-melanoma cases. Anais Brasileiros De Dermatologia, 88, 646-8. https://doi.org/10.1590/abd1806-4841.20132058
  20. Foroughi MR, Razi A, Golforoushan F (2008). Study on the results of surgical treatment of basal cell carcinoma on the scalp by secondary intention healing. Med J Tabriz Univ Med Sci, 30, 97-104.
  21. Ghojazadeh M, Mohammadi M, Azami-Aghdash S, et al (2013). Estimation of cancer cases using capture-recapture method in Northwest Iran. Asian Pac J Cancer Prev, 14, 3237-41. https://doi.org/10.7314/APJCP.2013.14.5.3237
  22. Hirokawa D, Lee JB (2011). Dermatoscopy: an overview of subsurface morphology. Clinics Dermatology, 29, 557-65. https://doi.org/10.1016/j.clindermatol.2010.12.002
  23. Johr RH (2002). Dermoscopy: alternative melanocytic algorithms-the ABCD rule of dermatoscopy, menzies scoring method, and 7-point checklist. Clinics dermatol, 20, 240-7. https://doi.org/10.1016/S0738-081X(02)00236-5
  24. Khanage SG, Raju SA, Mohite PB, et al (2012). Synthesis and pharmacological evaluation of some new pyrimidine derivatives containing 1, 2, 4-triazole. Advanced Pharm Bull, 2, 213.
  25. Kaya G, Braun R, Marghoob A, et al (2005). Histopathological correlation in dermoscopy. Atlas of Dermoscopy, 23-41.
  26. Longo C, Zalaudek I, Moscarella E, et al (2014). Clonal seborrheic keratosis: dermoscopic and confocal microscopy characterization. J Eur AcadDermatol Venereol, 28, 1397-400. https://doi.org/10.1111/jdv.12261
  27. Lotfinegad P (2014). Immunomodulatory nature and site specific affinity of mesenchymal stem cells: a hope in cell therapy. Advanced Pharm Bull, 4, 5.
  28. Mansoori B, Shotorbani SS, Baradaran B (2014). RNA Interference and its Role in Cancer Therapy. Advanced Pharm Bull, 4, 313.
  29. Argenziano G, Soyer HP, Chimenti S, et al (2003). Dermoscopy of pigmented skin lesions: results of a consensus meeting via the Internet. J Am Acad Dermatol, 48, 679-93. https://doi.org/10.1067/mjd.2003.281
  30. Argenziano G, Zalaudek I, Ferrara G, et al (2007). Dermoscopy features of melanoma incognito: indications for biopsy. J Am Acad Dermatol, 56, 508-13. https://doi.org/10.1016/j.jaad.2006.10.029
  31. Atherton D, Moss C (1998). Naevi and other developmental defects. Rook's Textbook of Dermatology, Seventh Edition, 569-682.
  32. Wang SQ, Kopf AW, Koenig K, et al (2004). Detection of melanomas in patients followed up with total cutaneous examinations, total cutaneous photography, and dermoscopy. J Am Acad Dermatol, 50, 15-20. https://doi.org/10.1016/S0190-9622(03)02794-4
  33. Weismann K, Osterlind A, Thomsen H (1995). Dermatoscopy. An investigative method for the diagnosis of pigmented skin tumors. Ugeskrift for laeger, 157, 147-52.