- Volume 20 Issue 4
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Analysis of Pyrethroid Resistance Allele in Malaria Vector Anopheles sinensis from Malaria High-risk Area
말라리아 위험지역에서 채집된 말라리아 매개모기 Anopheles sinensis의 피레스로이드계 저항성 대립형질 분석
- Choi, Kwang Shik (School of Life Science, College of Natural Sciences, Kyungpook National University) ;
- Lee, Seung-Yeol (School of Applied Biosciences, College of Agriculture and Life Sciences, Kyungpook National University) ;
- Hwang, Do-Un (School of Life Science, College of Natural Sciences, Kyungpook National University) ;
- Kim, Heung-Chul (5th Medical Detachment, 168th Multifunctional Medical Battalion, 65th Medical Brigade) ;
- Chang, Kyu-Sik (Division of Medical Entomology, Korea Center for Disease Control and Prevention) ;
- Jung, Hee-Young (School of Applied Biosciences, College of Agriculture and Life Sciences, Kyungpook National University)
- 최광식 (경북대학교 자연과학대학 생명과학부) ;
- 이승열 (경북대학교 농업생명과학대학 응용생명과학부) ;
- 황도운 (경북대학교 자연과학대학 생명과학부) ;
- 김흥철 (주한 미8군 65의무여단 168대대, 5의무대) ;
- 장규식 (질병관리본부 질병매개곤충과) ;
- 정희영 (경북대학교 농업생명과학대학 응용생명과학부)
- Received : 2016.10.08
- Accepted : 2016.11.29
- Published : 2016.12.31
Malaria is mainly transmitted by Anopheles sinensis which is dominant species in malaria high-risk area, northern part of Gyeonggi province in Korea. Pyrethroid insecticide is used for malaria vector, An. sinensis in Korea and the previous investigation consistently reported insecticide resistance from the vector. This study investigated insecticide susceptible and resistant alleles from An. sinensis and the status of malaria vector control in malaria high-risk area. For the study, An. sinensis collected from Paju, Gimpo and Ganghwa were sequenced for kdr detection. In Paju, there was no homozygous susceptibility and all of tested samples had homozygous or heterozygous resistance. There were 6.7% for susceptible homozygosity and 93.3% for resistant homozygosity or heterozygosity in Gimpo. Furthermore, the percentages of homozygous susceptibility and homozygous or heterozygous resistance in Ganghwa were 5.7% and 94.3% respectively. The results showed that the frequency of the insecticide resistance from An. sinensis in malaria high-risk area were increased much more than the previous investigation. Hence, this study suggests that malaria vector control programs should have to be prepared for the management of pyrethroid insecticide resistance.
Grant : BK21플러스
Supported by : 경북대학교
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