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The Anti-melanogenic Effect of Geranium krameri Extract

선이질풀 추출물의 멜라닌 생성 억제 효과

  • Received : 2015.11.11
  • Accepted : 2015.12.04
  • Published : 2016.02.29

초록

본 연구에서 국립원예특작과학원 인삼특작부 추출물은행에서 분양받은 에탄올 추출물 시료(시료번호: 4)인 선이질풀(Geranium krameri)에 대한 다양한 생리활성을 조사하여 기능성소재 응용가능성을 검토하였다. 선이질풀 추출물은 멜라노마 세포에 대하여 낮은 세포독성을 나타냈다. 세포독성이 거의 없는 농도에서 선이질풀 추출물 처리 시 산화방지 활성($IC_{50}$, $8.72{\mu}g/mL$) 및 B. subtilis, E. coli, C. albicans에 대한 항균활성이 우수하게 나타났으며 타이로시네이즈 활성저해($IC_{50}$, $456.86{\mu}g/mL$) 및 멜라닌 함량 저하($IC_{50}$, $50.35{\mu}g/mL$)를 보여주었다. 또한, B16F10 세포에서 선이질풀 추출물 농도 의존적으로 타이로시네이즈 발현이 억제되었으며, 이는 선이질풀 추출물이 직접적인 타이로시네이즈 활성저해 및 세포 내 타이로시네이즈 발현을 억제시킴으로서 멜라닌 합성을 저해하는 것으로 판단된다. 이와 같은 결과로 미루어볼 때 선이질풀 추출물은 피부미백 소재 등 피부개선 효과를 지닌 기능성 화장품에 활용하기 위한 매우 효과적인 재료가 될 수 있다고 판단된다.

키워드

Geranium krameri;melanin;tyrosinase

참고문헌

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피인용 문헌

  1. Anti-oxidant and Anti-melanogenic Activity of the Methanol Extract of Pine Cone vol.14, pp.3, 2016, https://doi.org/10.20402/ajbc.2016.0055
  2. extract on α-MSH induced melanin synthesis vol.60, pp.4, 2017, https://doi.org/10.3839/jabc.2017.051

과제정보

연구 과제 주관 기관 : 한국연구재단(NRF)