Levels of Plasma Glucose and Lipid in Rats Fed Bread Supplemented with Natural Extracts

천연추출물이 첨가된 식빵을 섭취한 흰쥐의 혈당 및 지질수준에 미치는 영향

  • Kim, Se-Wook (Department of Biotechnology, College of Life Science & Biotechnology, Korea University) ;
  • Han, Ah-Ram (Department of Biotechnology, College of Life Science & Biotechnology, Korea University) ;
  • Chun, Su-Hyun (Department of Biotechnology, College of Life Science & Biotechnology, Korea University) ;
  • Nam, Mi-Hyun (Department of Biotechnology, College of Life Science & Biotechnology, Korea University) ;
  • Hong, Chung-Oui (Department of Biotechnology, College of Life Science & Biotechnology, Korea University) ;
  • Kim, Bok Hee (CJ Food ville Bakery R&D) ;
  • Kim, Tae Cheol (CJ Food ville Bakery R&D) ;
  • Lee, Kwang-Won (Department of Biotechnology, College of Life Science & Biotechnology, Korea University)
  • Received : 2015.12.03
  • Accepted : 2016.02.15
  • Published : 2016.02.29


In this study, 4-week-old rats were fed bread supplemented with Terminalia chebula (TC), Plantago asiatica (PA), Linder obtusiloba (LO), and Capsosiphon fulvescens (CF) ethanol extracts, to determine the decrease in blood glucose levels, as well as the anti-inflammatory and lipid-enhancing effects. Previous studies have demonstrated the antioxidative effects of these ethanol extracts. After sacrifice, the liver tissue, whole blood, and serum samples were collected for biochemical analysis. The results showed a significant decrease in blood glucose level, lipid peroxidation, malondialdehyde (MDA) level, HbA1c level, total cholesterol, and low-density lipoprotein (LDL)-cholesterol (p<0.05) and an increase in high-density lipoprotein (HDL)-cholesterol level in rats fed bread supplemented with LO and CF ethanol extracts (p<0.05). Therefore, the results of this study demonstrate that bread supplemented with LO and CF ethanol extracts can potentially affect the blood glucose level and lead to lipid enhancement.


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