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Toxic Effects of Alumina Nanoparticles in Rat Cerebrums and Kidneys

산화알루미늄 나노물질이 랫드의 대뇌와 신장에 미치는 영향

Jo, Eunhye;Seo, Gyun-Baek;Kim, Hyunmi;Choi, Kyunghee;Kwon, Jung-Taek;Kim, Philje;Eom, Igchun
조은혜;서균백;김현미;최경희;권정택;김필제;엄익춘

  • Received : 2015.10.29
  • Accepted : 2015.12.09
  • Published : 2016.02.29

Abstract

Objectives: Alumina nanoparticles ($Al_2O_3$, Al-NPs) are used for various purposes, including as coating agents and paint additives. Their potential toxicity has raised concern for human health. This study focuses on exploring the toxic effects on the brain and kidneys caused by Al-NPs exposure in rats. Methods: The animals were orally administered Al-NPs at 10, 50 and 100 mg/kg body weight for 28 days following OECD TG 407. To determine the targeted toxicity of Al-NPs, histopathological examination and gene expression analysis were conducted on the rats. Results: The Al-NPs treatment induced kidney tubular dilatation. In the rat cerebrums, the expression levels of 126 genes experienced two-fold or greater increases in response to Al-NPs, including other genes encoding proteins involved in cell differentiation, transcription and signal transduction. In the rat kidneys, the expression levels of 152 genes also showed two-fold or greater increases in response to Al-NPs, including other genes encoding proteins involved in apoptosis, transcription and signal transduction. Conclusion: These results suggest that exposure to Al-NPs influences cellular signal pathways of kidney and cerebrum, and it can be a toxic indicators of nanometrials.

Keywords

Aluminum oxide;nanoparticles;toxicogenomics

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