Hangover relieving effect of Sanghwang mushroom mycelium extract

상황버섯 균사체 추출물의 숙취해소 효과에 관한 연구

  • 김민수 (제주대학교 수의과대학 수의학과) ;
  • 안유진 (제주대학교 수의과대학 수의학과) ;
  • 이재철 (제주대학교 수의과대학 수의학과) ;
  • 박가령 (제주대학교 수의과대학 수의학과) ;
  • 박동수 ((주)제주상황) ;
  • 전남근 ((주)제주상황) ;
  • 이영재 (제주대학교 수의과대학 수의학과) ;
  • 한창훈 (제주대학교 수의과대학 수의학과)
  • Received : 2016.05.16
  • Accepted : 2016.08.26
  • Published : 2016.12.31


This study was conducted to evaluate the hangover relieving effect of Sanghwang mushroom mycelium extract (SME). The extract showed 1,1-diphenyl-2-picrylhydrazyl radical scavenging effect in a concentration-dependent manner and high antioxidant capacity ($56.67{\pm}1.77%$) when administered at $120{\mu}g/mL$. In addition, SME significantly increased (p < 0.005) the aldehyde dehydronase (ALDH) activity ($126.03{\pm}9.11%$) when applied at 8 or $16{\mu}L/mL$. A locomotor activity test showed that the alcohol-water treated group showed significantly decreased motor activity at 90 min post-administration. However, the alcohol-SME treated group showed a 20-fold higher motor activity than that observed in the alcohol-water treated group at 90 min post-administration. Blood was harvested from each mouse at 90 min post-administration, and both alcohol and aldehyde concentrations were measured. The alcohol-SME treated group showed significantly lower (p < 0.5) alcohol ($120.13{\pm}12.83{\mu}g/mL$) and aldehyde ($7.26{\pm}1.22{\mu}g/mL$) concentrations than the values observed in the alcohol-water treated group. These results suggest that the hangover relieving effect of SME results from increased ALDH activity, which reduces the aldehyde concentration in the blood.


Supported by : 제주대학교


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