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Hangover relieving effect of Sanghwang mushroom mycelium extract

상황버섯 균사체 추출물의 숙취해소 효과에 관한 연구

  • 김민수 (제주대학교 수의과대학 수의학과) ;
  • 안유진 (제주대학교 수의과대학 수의학과) ;
  • 이재철 (제주대학교 수의과대학 수의학과) ;
  • 박가령 (제주대학교 수의과대학 수의학과) ;
  • 박동수 ((주)제주상황) ;
  • 전남근 ((주)제주상황) ;
  • 이영재 (제주대학교 수의과대학 수의학과) ;
  • 한창훈 (제주대학교 수의과대학 수의학과)
  • Received : 2016.05.16
  • Accepted : 2016.08.26
  • Published : 2016.12.31

Abstract

This study was conducted to evaluate the hangover relieving effect of Sanghwang mushroom mycelium extract (SME). The extract showed 1,1-diphenyl-2-picrylhydrazyl radical scavenging effect in a concentration-dependent manner and high antioxidant capacity ($56.67{\pm}1.77%$) when administered at $120{\mu}g/mL$. In addition, SME significantly increased (p < 0.005) the aldehyde dehydronase (ALDH) activity ($126.03{\pm}9.11%$) when applied at 8 or $16{\mu}L/mL$. A locomotor activity test showed that the alcohol-water treated group showed significantly decreased motor activity at 90 min post-administration. However, the alcohol-SME treated group showed a 20-fold higher motor activity than that observed in the alcohol-water treated group at 90 min post-administration. Blood was harvested from each mouse at 90 min post-administration, and both alcohol and aldehyde concentrations were measured. The alcohol-SME treated group showed significantly lower (p < 0.5) alcohol ($120.13{\pm}12.83{\mu}g/mL$) and aldehyde ($7.26{\pm}1.22{\mu}g/mL$) concentrations than the values observed in the alcohol-water treated group. These results suggest that the hangover relieving effect of SME results from increased ALDH activity, which reduces the aldehyde concentration in the blood.

Acknowledgement

Supported by : 제주대학교

References

  1. Ahn YT, Bae JS, Kim YH, Lim KS, Huh CS. Effects of fermented milk intake on hepatic antioxidative systems in alcohol treated rats. Korean J Food Sci Technol 2005, 37, 631-635.
  2. Albano E. Free radical mechanisms in immune reactions associated with alcoholic liver disease. Free Radic Biol Med 2002, 32, 110-114. https://doi.org/10.1016/S0891-5849(01)00773-0
  3. Aoshima H, Tsunoue H, Koda H, Kiso Y. Aging of whiskey increases 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity. J Agric Food Chem 2004, 52, 5240-5244. https://doi.org/10.1021/jf049817s
  4. Cho SH, Kim JC, Kim SW. Effect of plant extracts on the activity of alcohol dehydrogenase and the antioxidation in alcohol-treated rat hepatocyte. J Korean Soc Food Sci Nutr 2001, 30, 679-683.
  5. Choo MH, Lee JJ, Lee MY. Effect of Pimpinella brachycarpa ethanol extract on chronically ethanol-induced liver damage in rats. J Life Sci 2007, 17, 1406-1413. https://doi.org/10.5352/JLS.2007.17.10.1406
  6. Das SK, Vasudevan DM. Alcohol-induced oxidative stress. Life Sci 2007, 81, 177-187. https://doi.org/10.1016/j.lfs.2007.05.005
  7. Forsander OA, Raiha NCR. Metabolites produced in the liver during alcohol oxidation. J Biol Chem 1960, 235, 34-36.
  8. Glueck CJ, Hogg E, Allen C, Gartside PS. Effects of alcohol ingestion on lipids and lipoproteins in normal men: isocaloric metabolic studies. Am J Clin Nutr 1980, 33, 2287-2293. https://doi.org/10.1093/ajcn/33.11.2287
  9. Heinecke JW. Free radical modification of low-density lipoprotein: mechanisms and biological consequences. Free Radic Biol Med 1987, 3, 65-73. https://doi.org/10.1016/0891-5849(87)90040-2
  10. Jernigan TL, Ostergaard AL. When alcoholism affects memory functions: MRI of the brain. Alcohol Health Res World 1995, 19, 104-107.
  11. Kim JS. Effect of an alcohol detoxification beverage (ADB) contained Radix puerariae and Bambusae caules in Liquamen Phyllostachyos on the alcohol administered mouse. J Korean Soc Food Sci Nutr 2004, 33, 318-323. https://doi.org/10.3746/jkfn.2004.33.2.318
  12. Kim MS, Kim SN, Park HS. Effect of chronical ethanol ingestion on the levels of fatty acid ethyl esters (FAEEs) and lipid peroxidation in rat tissues. Korean J Nutr 2007, 40, 413-418.
  13. Ko BS, Jang JS, Hong SM, Kim DW, Sung SR, Park HR, Lee JE, Jeon WK, Park SM. Effect of new remedies mainly comprised of Hovenia dulcis Thunb on alcohol degradation and liver protection in Sprague Dawley male rats. J Korean Soc Food Sci Nutr 2006, 35, 828-834. https://doi.org/10.3746/jkfn.2006.35.7.828
  14. Konno S, Chu K, Feuer N, Phillips J, Choundhury M. Potent anticancer effects of bioactive mushroom extracts (Phellinus linteus) on a variety of human cancer cells. J Clin Med Res 2015, 7, 76-82. https://doi.org/10.14740/jocmr1996w
  15. Kwon SH, Kim CN, Kim CY, Kwon ST, Park KM, Hwangbo S. Antitumor activities of protein-bound polysaccharide extracted from mycelia of mushroom. Korean J Food Nutr 2003 16, 15-21.
  16. Lee BE, Ryu SY, Kim EH, Kim YH, Kwak KA, Song HY. Immunostimulating effect of mycelium extract of Phellinus linteus. Korean J Pharmacogn 2012, 43, 157-162.
  17. Lee MS, Hwang BS, Lee IK, Seo GS, Yun BS. Chemical constituents of the culture broth of Phellinus linteus and their antioxidant activity. Mycobiology 2015, 43, 43-48. https://doi.org/10.5941/MYCO.2015.43.1.43
  18. Lieber CS. Alcohol and liver: 1994 update. Gastroenterology 1994, 106, 1085-1105. https://doi.org/10.1016/0016-5085(94)90772-2
  19. Lieber CS. Ethanol metabolism, cirrhosis and alcoholism. Clin Chim Acta 1997, 257, 59-84. https://doi.org/10.1016/S0009-8981(96)06434-0
  20. Lieber CS. Hepatic, metabolic and toxic effects of ethanol: 1991 update. Alcohol Clin Exp Res 1991, 15, 573-592. https://doi.org/10.1111/j.1530-0277.1991.tb00563.x
  21. Mezey E. Alcoholic liver disease: roles of alcohol and malnutrition. Am J Clin Nutr 1980, 33, 2709-2718. https://doi.org/10.1093/ajcn/33.12.2709
  22. Morel DW, DiCorleto PE, Chisolm GM. Endothelial and smooth muscle cells alter low density lipoprotein in vitro by free radical oxidation. Arteriosclerosis 1984, 4, 357-364. https://doi.org/10.1161/01.ATV.4.4.357
  23. Noh KH, Jang JH, Kim JJ, Shin JH, Kim DK, Song YS. Effect of dandelion juice supplementation on alcohol-induced oxidative stress and hangover in healthy male college students. J Korean Soc Food Sci Nutr 2009, 38, 683-693. https://doi.org/10.3746/jkfn.2009.38.6.683
  24. Park EM, Ye EJ, Kim SJ, Choi HI, Bae MJ. Eliminatory effect of health drink containing Hovenia dulcis Thunb extract on ethanol-induced hangover in rats. J Korean Soc Food Cult 2006, 21, 71-75.
  25. Park IH, Chung SK, Lee KB, Yoo YC, Kim SK, Kim GS, Song KS. An antioxidant hispidin from the mycelial cultures of Phellinus linteus. Arch Pharm Res 2004, 27, 615-618. https://doi.org/10.1007/BF02980159
  26. Pemberton PW, Smith A, Warnes TW. Non-invasive monitoring of oxidant stress in alcoholic liver disease. Scand J Gastroenterol 2005, 40, 1102-1108. https://doi.org/10.1080/00365520510023495
  27. Shin JH, Lee SJ, Choi DJ, Kang MJ, Sung NJ. Antioxidant and alcohol dehydrogenase activity of water extracts from abalone containing medicinal plants. Korean J Food Cook Sci 2008, 24, 182-187.
  28. Sohn HY, Shin YK, Kim JS. Anti-proliferative activities of solid-state fermented medicinal herbs using Phellinus baumii against human colorectal HCT116 cell. J Life Sci 2010, 20, 1268-1275. https://doi.org/10.5352/JLS.2010.20.8.1268
  29. Song I, Choi IS, Yoon HK, Koo SJ. The effect of Camellia sinensis LINNE on alcohol concentration and hangover in normal healthy students. Korean J Food Cook Sci 2005, 21, 591-598.
  30. Takase S, Takada A, Yasuhara M, Tsutsumi M. Hepatic aldehyde dehydrogenase activity in liver diseases, with particular emphasis on alcoholic liver disease. Hepatology 1989, 9, 704-709. https://doi.org/10.1002/hep.1840090508
  31. Vidal F, Toda R, Gutierrez C, Broch M, Fernandez-Muixi F, Lorenzo A, Richart C. Influence of chronic alcohol abuse and liver disease on hepatic aldehyde dehydrogenase activity. Alcohol 1998, 15, 3-8. https://doi.org/10.1016/S0741-8329(97)00073-6
  32. Yan GH, Choi YH. Phellinus linteus extract exerts antiasthmatic effects by suppressing NF-${\kappa}B$ and p38 MAPK activity in an OVA-induced mouse model of asthma. Immune Netw 2014, 14, 107-115. https://doi.org/10.4110/in.2014.14.2.107

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