DOI QR코드

DOI QR Code

The Leaf of Diospyros kaki Thumb Ameliorates Renal Oxidative Damage in Mice with Type 2 Diabetes

  • Choi, Myung-Sook (Department of Food Science and Nutrition, Kyungpook National University) ;
  • Jeong, Mi Ji (Department of Food Science and Nutrition, Pukyong National University) ;
  • Park, Yong Bok (School of Life Sciences and Biotechnology, Kyungpook National University) ;
  • Kim, Sang Ryong (School of Life Sciences and Biotechnology, Kyungpook National University) ;
  • Jung, Un Ju (Department of Food Science and Nutrition, Pukyong National University)
  • 투고 : 2016.07.26
  • 심사 : 2016.12.06
  • 발행 : 2016.12.31

초록

Diabetic kidney disease is the most common and severe chronic complication of diabetes. The leaf of Diospyros kaki Thumb (persimmon) has been commonly used for herbal tea and medicinal purposes to treat a variety of conditions, including hypertension and atherosclerosis. However, the effect of persimmon leaf on kidney failure has not been investigated. This study aimed to examine the role of persimmon leaf in protecting the diabetes-associated kidney damage in a mouse model of type 2 diabetes. Mice were fed either a normal chow diet with or without powered persimmon leaf (5%, w/w) for 5 weeks. In addition to kidney morphology and blood markers of kidney function, we assessed levels of oxidative stress markers as well as antioxidant enzymes activities and mRNA expression in the kidney. Supplementation of the diet with powered persimmon leaf not only decreased the concentration of blood urea nitrogen in the plasma but also improved glomerular hypertrophy. Furthermore, the persimmon leaf significantly decreased the levels of hydrogen peroxide and lipid peroxide in the kidney. The activities of superoxide dismutase, catalase, and glutathione peroxidase and the mRNA expression of their respective genes were also increased in the kidney of persimmon leaf-supplemented db/db mice. Taken together, these results suggest that supplementation with the persimmon leaf may have protective effects against type 2 diabetes-induced kidney dysfunction and oxidative stress.

과제정보

연구 과제 주관 기관 : Pukyong National University

참고문헌

  1. Ozbek E. 2012. Induction of oxidative stress in kidney. Int J Nephrol 2012: 465897.
  2. Modi GK, Jha V. 2006. The incidence of end-stage renal disease in India: a population-based study. Kidney Int 70: 2131-2133. https://doi.org/10.1038/sj.ki.5001958
  3. Jha V, Wang AY, Wang H. 2012. The impact of CKD identification in large countries: the burden of illness. Nephrol Dial Transplant 27: iii32-iii38.
  4. Molitch ME, DeFronzo RA, Franz MJ, Keane WF, Mogensen CE, Parving HH, Steffes MW; American Diabetes Association. 2004. Nephropathy in diabetes. Diabetes Care 27: s79-s83. https://doi.org/10.2337/diacare.27.2007.S79
  5. Thomas MC, Cooper ME, Zimmet P. 2016. Changing epidemiology of type 2 diabetes mellitus and associated chronic kidney disease. Nat Rev Nephrol 12: 73-81.
  6. Chen G, Wang ZQ, Jia JM. 2009. Three minor novel triterpenoids from the leaves of Diospyros kaki. Chem Pharm Bull 57: 532-535. https://doi.org/10.1248/cpb.57.532
  7. Kawakami K, Aketa S, Nakanami M, Iizuka S, Hirayama M. 2010. Major water-soluble polyphenols, proanthocyanidins, in leaves of persimmon (Diospyros kaki) and their $\alpha$-amylase inhibitory activity. Biosci Biotechnol Biochem 74: 1380-1385. https://doi.org/10.1271/bbb.100056
  8. Sun L, Zhang J, Lu X, Zhang L, Zhang Y. 2011. Evaluation to the antioxidant activity of total flavonoids extract from persimmon (Diospyros kaki L.) leaves. Food Chem Toxicol 49: 2689-2696. https://doi.org/10.1016/j.fct.2011.07.042
  9. Xie C, Xie Z, Xu X, Yang D. 2015. Persimmon (Diospyros kaki L.) leaves: a review on traditional uses, phytochemistry and pharmacological properties. J Ethnopharmacol 163: 229-240. https://doi.org/10.1016/j.jep.2015.01.007
  10. Bae UJ, Park SH, Jung SY, Park BH, Chae SW. 2015. Hypoglycemic effects of aqueous persimmon leaf extract in a murine model of diabetes. Mol Med Rep 12: 2547-2554. https://doi.org/10.3892/mmr.2015.3766
  11. Jung UJ, Park YB, Kim SR, Choi MS. 2012. Supplementation of persimmon leaf ameliorates hyperglycemia, dyslipidemia and hepatic fat accumulation in type 2 diabetic mice. PLoS One 7: e49030. https://doi.org/10.1371/journal.pone.0049030
  12. Lee SC, Prosky L, De Vries JW. 1992. Determination of total, soluble, and insoluble dietary fiber in foods: enzymatic-gravimetric method, MES-TRIS buffer: collaborative study. J AOAC Int 75: 395-416.
  13. Singleton VL, Orthofer R, Lamuela-Raventos RM. 1999. Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. Methods Enzymol 299: 152-178. https://doi.org/10.1016/S0076-6879(99)99017-1
  14. Moreno MI, Isla MI, Sampietro AR, Vattuone MA. 2000. Comparison of the free radical-scavenging activity of propolis from several regions of Argentina. J Ethnopharmacol 71: 109-114. https://doi.org/10.1016/S0378-8741(99)00189-0
  15. Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254. https://doi.org/10.1016/0003-2697(76)90527-3
  16. Marklund S, Marklund G. 1974. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 47: 469-474. https://doi.org/10.1111/j.1432-1033.1974.tb03714.x
  17. Aebi H. 1974. Catalase in method of enzymatic analysis. Bergmeyer HU, ed. Academic Press Inc., New York, NY, USA. Vol 2, p 673-684.
  18. Paglia DE, Valentine WN. 1967. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70: 158-169.
  19. Wolff SP. 1994. Ferrous ion oxidation in presence of ferric ion indicator xylenol orange for measurement of hydroperoxides. Methods Enzymol 233: 182-189. https://doi.org/10.1016/S0076-6879(94)33021-2
  20. Ohkawa H, Ohishi N, Yagi K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95: 351-358. https://doi.org/10.1016/0003-2697(79)90738-3
  21. Chomczynski P, Sacchi N. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159.
  22. Lopez-Novoa JM, Rodriguez-Pena AB, Ortiz A, Martinez-Salgado C, Lopez Hernandez FJ. 2011. Etiopathology of chronic tubular, glomerular and renovascular nephropathies: clinical implications. J Transl Med 9: 13. https://doi.org/10.1186/1479-5876-9-13
  23. Cohen MP, Clements RS, Cohen JA, Shearman CW. 1996. Prevention of decline in renal function in the diabetic db/db mouse. Diabetologia 39: 270-274. https://doi.org/10.1007/BF00418341
  24. Sharma K, McCue P, Dunn SR. 2003. Diabetic kidney disease in the db/db mouse. Am J Physiol Renal Physiol 284: F1138-F1144. https://doi.org/10.1152/ajprenal.00315.2002
  25. Baumgarten M, Gehr T. 2011. Chronic kidney disease: detection and evaluation. Am Fam Physician 84: 1138-1148.
  26. Sun SZ, Wang Y, Li Q, Tian YJ, Liu MH, Yu YH. 2006. Effects of benazepril on renal function and kidney expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in diabetic rats. Chin Med J 119: 814-821.
  27. Chiavaroli L, Mirrahimi A, Sievenpiper JL, Jenkins DJ, Darling PB. 2015. Dietary fiber effects in chronic kidney disease: a systematic review and meta-analysis of controlled feeding trials. Eur J Clin Nutr 69: 761-768. https://doi.org/10.1038/ejcn.2014.237
  28. Fujii H, Iwase M, Ohkuma T, Ogata-Kaizu S, Ide H, Kikuchi Y, Idewaki Y, Joudai T, Hirakawa Y, Uchida K, Sasaki S, Nakamura U, Kitazono T. 2013. Impact of dietary fiber intake on glycemic control, cardiovascular risk factors and chronic kidney disease in Japanese patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry. Nutr J 12: 159. https://doi.org/10.1186/1475-2891-12-159
  29. Granata S, Dalla Gassa A, Tomei P, Lupo A, Zaza G. 2015. Mitochondria: a new therapeutic target in chronic kidney disease. Nutr Metab 12: 49. https://doi.org/10.1186/s12986-015-0044-z
  30. Badal SS, Danesh FR. 2014. New insights into molecular mechanisms of diabetic kidney disease. Am J Kidney Dis 63: S63-S83. https://doi.org/10.1053/j.ajkd.2013.10.047
  31. Fridovich I. 1995. Superoxide radical and superoxide dismutases. Annu Rev Biochem 64: 97-112. https://doi.org/10.1146/annurev.bi.64.070195.000525
  32. Evans JL, Goldfine ID, Maddux BA, Grodsky GM. 2002. Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev 23: 599-622. https://doi.org/10.1210/er.2001-0039
  33. Halliwell B. 1995. Antioxidant characterization: methodology and mechanism. Biochem Pharmacol 49: 1341-1348. https://doi.org/10.1016/0006-2952(95)00088-H
  34. Kedziora-Kornatowska KZ, Luciak M, Paszkowski J. 2000. Lipid peroxidation and activities of antioxidant enzymes in the diabetic kidney: effect of treatment with angiotensin convertase inhibitors. IUBMB Life 49: 303-307. https://doi.org/10.1080/15216540050033177
  35. Sadi G, Eryilmaz N, Tutuncuoglu E, Cingir S, Guray T. 2012. Changes in expression profiles of antioxidant enzymes in diabetic rat kidneys. Diabetes Metab Res Rev 28: 228-235. https://doi.org/10.1002/dmrr.1302
  36. Sellamuthu PS, Arulselvan P, Kamalraj S, Fakurazi S, Kandasamy M. 2013. Protective nature of mangiferin on oxidative stress and antioxidant status in tissues of streptozotocin-induced diabetic rats. ISRN Pharmacol 2013: 750109.
  37. Singh AB, Akanksha, Singh N, Maurya R, Srivastava AK. 2009. Anti-hyperglycaemic, lipid lowering and anti-oxidant properties of [6]-gingerol in db/db mice. Int J Med Med Sci 1: 536-544.
  38. Fujita H, Fujishima H, Chida S, Takahashi K, Qi Z, Kanetsuna Y, Breyer MD, Harris RC, Yamada Y, Takahashi T. 2009. Reduction of renal superoxide dismutase in progressive diabetic nephropathy. J Am Soc Nephrol 20: 1303-1313. https://doi.org/10.1681/ASN.2008080844
  39. DeRubertis FR, Craven PA, Melhem MF. 2007. Acceleration of diabetic renal injury in the superoxide dismutase knockout mouse: effects of tempol. Metabolism 56: 1256-1264. https://doi.org/10.1016/j.metabol.2007.04.024
  40. DeRubertis FR, Craven PA, Melhem MF, Salah EM. 2004. Attenuation of renal injury in db/db mice overexpressing superoxide dismutase. Diabetes 53: 762-768. https://doi.org/10.2337/diabetes.53.3.762
  41. Brezniceanu ML, Liu F, Wei CC, Tran S, Sachetelli S, Zhang SL, Guo DF, Filep JG, Ingelfinger JR, Chan JS. 2007. Catalase overexpression attenuates angiotensinogen expression and apoptosis in diabetic mice. Kidney Int 71: 912-923. https://doi.org/10.1038/sj.ki.5002188
  42. Mohammedi K, Patente TA, Bellili-Munoz N, Driss F, Le Nagard H, Fumeron F, Roussel R, Hadjadj S, Correa-Giannella ML, Marre M, Velho G. 2016. Glutathione peroxidase-1 gene (GPX1) variants, oxidative stress and risk of kidney complications in people with type 1 diabetes. Metabolism 65: 12-19. https://doi.org/10.1016/j.metabol.2015.10.004