α-Glucosidase 저해물질을 함유한 노랑느타리버섯 (Pleurotus cornucopiae) 물추출물의 혈당상승 억제 효과

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DOI QR Code

신자원;배상민;한상민;이윤혜;정윤경;지정현;이종수
Shin, Ja-Won;Bae, Sang-Min;Han, Sang-Min;Lee, Yun-Hae;Jeong, Youn-Kyung;Ji, Jeong-Hyun;Lee, Jong-Soo

  • 투고 : 2016.01.18
  • 심사 : 2016.03.09
  • 발행 : 2016.03.31

초록

식용버섯 자실체를 이용하여 새로운 식후 혈당상승억제물질을 개발하기 위하여 노랑느타리버섯 자실체에 함유되어있는 ${\alpha}$-glucosidase 저해물질을 증류수로 추출하여 식후 혈당 상승억제효과를 조사하였다. ${\alpha}$-Glucosidase 저해물질을 함유한 노랑느타리버섯 물추출물은 streptozotocin으로 당뇨를 유발시킨 당뇨 쥐에서 장기 30 mg/kg, 150 mg/kg 경구투여(2일)와 단기 500 mg/kg, 1,000 mg/kg 경구투여(120분)시 모두, 농도 의존적으로 식후 혈당상승억제 효과를 보였다.

키워드

Antihyperglycemic effects;${\alpha}$-Glucosidase inhibitor;Pleurotus cornucopiae;Water extracts

참고문헌

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