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Association of Exposure to Chemicals with Dyspnea among Employed Workers: Analysis of the 3rd Korean Working Conditions Survey

근로자의 화학적 노출과 주관적 호흡곤란 증상간의 연관성: 3차 근로환경조사 자료 분석

Park, Moon-Young;Hwang, Sung-Ho;Hong, Kimyong;Oh, Se-Eun;Lee, Kyoung-Mu
박문영;황성호;홍기명;오세은;이경무

  • Received : 2015.10.06
  • Accepted : 2016.03.24
  • Published : 2016.03.31

Abstract

Objectives: The purpose of this study was to investigate whether chemical exposure among workers has relevance to dyspnea using data from the $3^{rd}$ Korea Working Conditions Survey. Methods: The research subjects were 29,711 wage workers. Chemical exposures consist of four factors, (1) breathing in vapors, fumes, dust and dirt, (2) breathing in organic solvent vapors, (3) handling or touching chemicals, and (4) secondhand smoke. Multiple logistic regression analysis was performed to examine the association between chemical exposure and dyspnea in the last 12months using proc surveylogistic in SAS 9.3 statistical software excluding people who had received a diagnosis of hypertension or obesity that can affect the respiratory distress symptoms(n=27,842). Results: Chemical exposure among workers was associated with dyspnea after adjustment for demographics and job characteristics. Prevalence of dyspnea was 4.9 per 1,000 among men and 5.8 per 1,000. Compared to a total score of 0 points of chemical exposure among workers, a total score of 1, 2-3, and 4 points tended to have increased risk of dyspnea in a dose-response manner for both men (OR=1.43, 1.93, and 4.26; P-for trend=0.002) and women(OR=1.10, 2.81, and 7.70; P-for trend=0.002). Stratified analysis by duration of current job showed that the association between chemical exposure and dyspnea tended to get stronger until 15 years and then disappeared afterwards, which reflects healthy worker survivor effect. Conclusions: We observed significant association between chemical exposure and dyspnea using the data of the $3^{rd}$ Korea Working Conditions Survey. Our results warrants providing knowledge related to chemical exposure, performing prevention activities, and creating various health policies to protect workers.

Keywords

chemical exposure;dyspnea;Korea Working Conditions Survey;healthy worker survivor effect

References

  1. Baek SG, No IH. The effects of toluene inhalation on blood toluene concentration in time sequence and behavioral change in rats. The Pharmaceutical Society of Korea Bimonthly 1996;40(5):545-549
  2. Burchell B, Fagan C. Gender and the intensification of work: Evidence from European working condition survey. Eastern Economic J 2004;30(4)
  3. Berg ND, Linnenberg A, Dirksen AD, Elberling J. Prevalence of self-reported sysmptoms and consequences related to inhalation of airborne chemicals in a Danish general population. Int Arch Occup Environ Health. 2008;81: 881-887 https://doi.org/10.1007/s00420-007-0282-0
  4. Chapman KR. Chronic obstructive pulmonary disease: are women more susceptibile than men? Clin Chest Med 2004;25:331-341. https://doi.org/10.1016/j.ccm.2004.01.003
  5. Gillis B, Gavin IM, Arbieva Z, King ST, Jayaraman S et al. Idendification of human cell responses to benzen and benzen metabolites. Genomics 2007;90:324-333 https://doi.org/10.1016/j.ygeno.2007.05.003
  6. Hong KH, Kim DS, Kwon OJ, Kim EA. The Prevalence of work related sickness absences according to the second korean working condition survey. Korean J Occup Environ Med 2011;23(4):428-438
  7. Husain R, Mushtag M, Seth PK. Effect of managanese on some aspects of carbohydrate metabolism in rats. Bull Environ Contam Toxicol 1980 Oct;25(4):646-50 https://doi.org/10.1007/BF01985585
  8. Kim CB, Kim KS. Association of work-related characterinstics and hypertension among white collar workers. Journal of Korean Society of Occupational and Environmental Hygiene. 2015:25(3):417-427.
  9. Kim GS, Go DH. Recently occupational diseases-chronic obstructive pulmonary disease(COPD). Korea Industrial Health Association Monthly 2009;6-21
  10. Kim HM, Shim IS, Seo GB, Lee MM, Yang SY, Kwon JT, Kim PJ et al. Toxicity effect on inhalation of rodents exposed to glutaraldehyde. Symposium and Conference Korea Society of Toxicology 2012;181-181
  11. Kim HY. A Study on the physical and chemical characteristics and hazards buthanethiol. J Korea Inst Gas 2013;17(4): 9-17
  12. Kim KA, Lim Y, Yun IG. Chronic hypersensitivity pneumonitis in a smelter. The Kor J Occup Med 1995;7(2):230-4
  13. Kim SY. Classification of occupational lung disease. Tuberculosis and Respiratory Diseases 1992;39(5): 380-385
  14. Kim YY. Occupational hypersensitivity pneumonotis. Tuberculosis and respiratory diseases 1993; 40(1):1-5
  15. Lee KM, Chun JB, Park DU, Lee WJ. Methods to minimize or adjust for healthy worker effect in occupational epidemiology. J Environ Health Sci 2011:37(5): 342-347
  16. Lee KM, Lee EJ. Latency period in occupational cancer in Korea - Analysis of data from the annual report on occupational cancers -. KNOU Journal 2013;56:211-221
  17. Lee SW, Go DH, Chin KW, Park DU, Lee JT et al. A case of hypersensitivity pneumonitis in a worker exposed to metal working fluid. Korea J Occup Environ Med 2008;20(1):37-45
  18. Lee WY. Clinical year-in-review of occupational lung disease. Tuberculosis and Respiratory Diseases 2011; 71(5):317-321 https://doi.org/10.4046/trd.2011.71.5.317
  19. Lim CH, Chung YH. Effects of didecyldimethylammonium chloride(DDAC) on sprague dawley rats by 2-weeks of inhalation exposure. Korea Society of Toxicology Symposium and Conference 2014;459-459
  20. Meldrum M, Rawbone R, Curran AD, Fishwick D. The role of occupation in the development of chronic obstructive pulmonary disease(COPD). Occup. Environ. Med. 2005;62(4):212-214 https://doi.org/10.1136/oem.2004.015511
  21. Mutti A, Falzoi M, Romannelli A, Bocchi MC, Ferroni C et al. Brain dopamine as a target for solvent toxicity: Effects of some monocyclic aromatic hydrocarbons. Toxicol. 1988;49:77-82 https://doi.org/10.1016/0300-483X(88)90177-1
  22. National Occupational Health and Safety Advisory Committee(NOHSAC) : Review of Schedule 2 of the Injury Prevention Rehabilitation and Compensation Act 2001 [cited 30 May 2008]. Available from : URL :http://www.nohsac.govt.nz/reviewschedule2/index.php?section=sec5:s4:p040
  23. Park DU, Choi YY. Comprehensive review of acute respiratory failure following inhalation exposure to waterproofing agents. Korean J Environ Health Sci 2012;38(6):451-459 https://doi.org/10.5668/JEHS.2012.38.6.451
  24. Rim KT, Kim SJ, Chung YH, Kim HY, Maeng SH, Yu IJ. DNA damages with Fpg/Endo III FLARE Assay in cynomolgus monkeys exposed to stainless steel welding fume. J Korean Soc Occup Environ Hyg 2007;17(4):272-281
  25. Yoo SH. Dyspnoea. the Korean National Tuberculosis Association 1999;46(4):4-7

Acknowledgement

Supported by : 한국방송통신대학교