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A Study on Surface Modification of Nanorod Electrodes for Highly Sensitive Nano-biosensor

고감도 나노-바이오센서를 위한 나노로드 전극 표면 개질에 관한 연구

  • Received : 2016.01.29
  • Accepted : 2016.03.10
  • Published : 2016.04.10

Abstract

Among many kinds of bioaffinity sensors, the avidin-biotin system has been widely used in a variety of biological applications due to the specific and high affinity interaction of the system. In this work, gold nanorods with high surface area were explored as electrodes in order to amplify the signal response from the avidin-biotin interaction which can be further utilized for avidin-biotin biosensors. Electrochemical performance of electrodes modified with nanorods and functionalized with avidin in response to interactions with biotin at various concentrations using $[Fe(CN)_6]^{3-/4-}$ couple as the redox probe were investigated using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). A very low biotin concentration of less than 1 ng/mL could be detected using the electrodes modified with nanorods.

Keywords

nano/biosensor;avidin/biotin;surface modification

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