Association of the Glutathione S-transferase T1 Null Genotype with Risk of Gastric Cancer: a Meta-analysis in Asian Populations

DOI QR코드

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Zeng, Yan;Bai, Jian;Deng, Li-Cong;Xie, Yu-Ping;Zhao, Fen;Huang, Ying

  • 발행 : 2016.04.11

초록

Background: A large number of studies have been published to investigate the association between the null genotype of glutathione S-transferase T1 (GSTT1) with gastric cancer. However, the results were inconsistent and conflicting. The aim of this study was to estimate the relationship between this polymorphism in the GSTT1 gene and gastric cancer risk in Asian populations by meta-analysis. Materials and Methods: A literature search was performed in PubMed, Embase, Chinese Biomedical database (CBM), Weipu database, Wanfang database, and China National Knowledge Infrastructure database (CNKI). Statistical analysis was conducted by using Review Manager 5.3. Results: Thirty-nine studies with a total of 7,737 gastric cancer cases and 10,823 controls were included in this meta-analysis. The meta-analysis of total studies showed that the null genotype in GSTT1 was associated with increased risk of gastric cancer in Asians (OR=1.19, 95% CI=1.08-1.31, p=0.0002). Subgroup analysis showed a significant relationship between GSTT1 null genotype and gastric cancer in East-Asians, as well as in subgroup analysis of hospital-based design. On subgroup analysis by smoking status, alcohol status, Helicobacter pylori infection status, and histology type, no significant association of this polymorphism with susceptibility to gastric cancer was found. Conclusions: In conclusion, the results showed that the null genotype of GSTT1 is significantly associated with an increased risk in gastric cancer in Asian populations.

키워드

GSTT1;polymorphism;gastric cancer;meta-analysis;Asia

참고문헌

  1. Acar H, Ozturk K, Muslumanoglu MH, et al (2006). Relation of glutathione S-transferase genotypes (GSTM1 and GSTT1) to laryngeal squamous cell carcinoma risk. Cancer Genet Cytogenet, 169, 89-93. https://doi.org/10.1016/j.cancergencyto.2005.12.007
  2. Al-Moundhri MS, Alkindy M, Al-Nabhani M, et al (2009). Combined polymorphism analysis of glutathione S-transferase M1/G1 and interleukin-1B (IL-1B)/interleukin 1-receptor antagonist (IL-1RN) and gastric cancer risk in an Omani Arab Population. J Clin Gastroenterol, 43, 152-6. https://doi.org/10.1097/MCG.0b013e31815853fa
  3. Cai L, Yu SZ, Chen J, S. (1999). Relationship between Glutathione S-Transferase M1 , T1 Genotype and Susceptibility to Gastric Cancer. Chinese J Prev Med, 6, 331-333.
  4. Cai L, Yu SZ, Zhang ZF (2001). Glutathione S-transferases M1, T1 genotypes and the risk of gastric cancer: a case-control study. World J Gastroenterol, 7, 506-9. https://doi.org/10.3748/wjg.v7.i4.506
  5. Choi SC, Yun KJ, Kim TH, et al (2003). Prognostic potential of glutathione S-transferase M1 and T1 null genotypes for gastric cancer progression. Cancer Lett, 195, 169-75. https://doi.org/10.1016/S0304-3835(03)00158-7
  6. Eom SY, Yim DH, Zhang Y, et al (2013). Dietary aflatoxin B1 intake, genetic polymorphisms of CYP1A2, CYP2E1, EPHX1, GSTM1, and GSTT1, and gastric cancer risk in Korean. Cancer Causes Control, 24, 1963-72. https://doi.org/10.1007/s10552-013-0272-3
  7. Feng JY, Sheng XB, Yan YY (2010). Multi-gene risk analysis of susceptibility genes on primary gastric cancer. Chinese J Public Health, 6, 688-9.
  8. Gao CM, Takezaki T, Wu JZ, et al (2002a). Glutathione-S-transferases M1 (GSTM1) and GSTT1 genotype, smoking, consumption of alcohol and tea and risk of esophageal and stomach cancers: a case-control study of a high-incidence area in Jiangsu Province, China. Cancer Lett, 188, 95-102. https://doi.org/10.1016/S0304-3835(02)00115-5
  9. Gao CM, Toshiro T, Wu JZ, et al (2002b). Effects of GSTT 1 and GSTM1 Genotypes , Lifestyle e Factors and Their Interactions on Risk of Esophageal and Stomach Cancers. China J Cancer Prev Treat, 2, 113-7.
  10. Garcia-Gonzalez MA, Quintero E, Bujanda L, et al (2012). Relevance of GSTM1, GSTT1, and GSTP1 gene polymorphisms to gastric cancer susceptibility and phenotype. Mutagenesis, 27, 771-7. https://doi.org/10.1093/mutage/ges049
  11. Gonzalez A, Ramirez V, Cuenca P, et al (2004). [Polymorphisms in detoxification genes CYP1A1, CYP2E1, GSTT1 and GSTM1 in gastric cancer susceptibility]. Rev Biol Trop, 52, 591-600.
  12. Haholu A, Berber U, Karagoz B, et al (2013). Is there any association of glutathione S-transferase T1 (GSTT1) and glutathione S-transferase M1 (GSTM1) gene polymorphism with gastric cancers? Pol J Pathol, 64, 247-52.
  13. Hayes JD, Strange RC (2000). Glutathione S-transferase polymorphisms and their biological consequences. Pharmacol, 61, 154-66. https://doi.org/10.1159/000028396
  14. Hong SH, Kim JW, Kim HG, et al (2006). [Glutathione S-transferases (GSTM1, GSTT1 and GSTP1) and N-acetyltransferase 2 polymorphisms and the risk of gastric cancer]. J Prev Med Public Health, 39, 135-40.
  15. Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
  16. Jing C, Huang ZJ, Duan YQ, et al (2012). Glulathione-S-transferases gene polymorphism in prediction of gastric cancer risk by smoking and Helicobacter pylori infection status. Asian Pac J Cancer Prev, 13, 3325-8. https://doi.org/10.7314/APJCP.2012.13.7.3325
  17. Kanavos P (2006). The rising burden of cancer in the developing world. Ann Oncol, 17, 15-23.
  18. Katoh T, Nagata N, Kuroda Y, et al (1996). Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) genetic polymorphism and susceptibility to gastric and colorectal adenocarcinoma. Carcinogenesis, 17, 1855-9. https://doi.org/10.1093/carcin/17.9.1855
  19. Liu J, Zhang WY, Wei Y (2003). GSTM1 and GSTT1 genetic polymorphisms and helicobacter pylori infection in gastric adenocarcinoma. J Mathematical Med, 1, 26-8.
  20. Liu L, Zhang D, Fan H (2013). GSTT1, GSTP1 gene polymorphism and genetic susceptibility to Nigeria hui cardiac cancer research. J Ningxiao Medical University.
  21. Liu R, Yin L, Pu Y, et al (2010). Functional alterations in the glutathione S-transferase family associated with enhanced occurrence of esophageal carcinoma in China. J Toxicol Environ Health A, 73, 471-82. https://doi.org/10.1080/15287390903523394
  22. Luo YP, Chen HC, Khan MA, et al (2011). Genetic polymorphisms of metabolic enzymes-CYP1A1, CYP2D6, GSTM1, and GSTT1, and gastric carcinoma susceptibility. Tumour Biol, 32, 215-22. https://doi.org/10.1007/s13277-010-0115-8
  23. Macarthur M, Hold GL, El-Omar EM (2004). Inflammation and Cancer II. Role of chronic inflammation and cytokine gene polymorphisms in the pathogenesis of gastrointestinal malignancy. Am J Physiol Gastrointest Liver Physiol, 286, 515-20. https://doi.org/10.1152/ajpgi.00475.2003
  24. Malakar M, Devi KR, Phukan RK, et al (2012). Genetic polymorphism of glutathione S-transferases M1 and T1, tobacco habits and risk of stomach cancer in Mizoram, India. Asian Pac J Cancer Prev, 13, 4725-32. https://doi.org/10.7314/APJCP.2012.13.9.4725
  25. Malik MA, Upadhyay R, Mittal RD, et al (2009). Role of xenobiotic-metabolizing enzyme gene polymorphisms and interactions with environmental factors in susceptibility to gastric cancer in Kashmir Valley. J Gastrointest Cancer, 40, 26-32. https://doi.org/10.1007/s12029-009-9072-0
  26. Martinez C, Martin F, Fernandez JM, et al (2006). Glutathione S-transferases mu 1, theta 1, pi 1, alpha 1 and mu 3 genetic polymorphisms and the risk of colorectal and gastric cancers in humans. Pharmacogenomics, 7, 711-8. https://doi.org/10.2217/14622416.7.5.711
  27. Masoudi M, Saadat I, Omidvari S, et al (2009). Genetic polymorphisms of GSTO2, GSTM1, and GSTT1 and risk of gastric cancer. Mol Biol Rep, 36, 781-4. https://doi.org/10.1007/s11033-008-9245-0
  28. Moy KA, Yuan JM, Chung FL, et al (2009). Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms and gastric cancer risk: a prospective study of men in Shanghai, China. Int J Cancer, 125, 2652-9. https://doi.org/10.1002/ijc.24583
  29. Mu LN, Lu QY, Yu SZ, et al (2005). Green tea drinking and multigenetic index on the risk of stomach cancer in a Chinese population. Int J Cancer, 116, 972-83. https://doi.org/10.1002/ijc.21137
  30. Nan HM, Park JW, Song YJ, et al (2005a). Kimchi and soybean pastes are risk factors of gastric cancer. World J Gastroenterol, 11, 3175-81. https://doi.org/10.3748/wjg.v11.i21.3175
  31. Nan HM, Song YJ, Yun HY, et al (2005b). Effects of dietary intake and genetic factors on hypermethylation of the hMLH1 gene promoter in gastric cancer. World J Gastroenterol, 11, 3834-41. https://doi.org/10.3748/wjg.v11.i25.3834
  32. Nebert DW, Ingelman-Sundberg M, Daly AK (1999). Genetic epidemiology of environmental toxicity and cancer susceptibility: human allelic polymorphisms in drug-metabolizing enzyme genes, their functional importance, and nomenclature issues. Drug Metab Rev, 31, 467-87. https://doi.org/10.1081/DMR-100101931
  33. Nguyen TV, Janssen MJ, van Oijen MG, et al (2010). Genetic polymorphisms in GSTA1, GSTP1, GSTT1, and GSTM1 and gastric cancer risk in a Vietnamese population. Oncol Res, 18, 349-55.
  34. Piao JM, Shin MH, Kweon SS, et al (2009). Glutathione-S-transferase (GSTM1, GSTT1) and the risk of gastrointestinal cancer in a Korean population. World J Gastroenterol, 15, 5716-21. https://doi.org/10.3748/wjg.15.5716
  35. Qian Y, Xu YC, Sheng HB (2001). A molecular epidemiological study on the relationship between glutathione s-transferase m1, t1 genetic polymorphism and susceptibility to gastric cancer. China Public Health, 2, 101-3.
  36. Qian Y, Xu YC, Sheng HB (2003). Relationship Between CYP2E1, GSTT1 Genetic Polymorphisms and S usceptibility to Gas tric Cancer. Chin J Prev Contr Chron Non-commun Dis, 3, 107-9.
  37. Roth MJ, Abnet CC, Johnson LL, et al (2004). Polymorphic variation of Cyp1A1 is associated with the risk of gastric cardia cancer: a prospective case-cohort study of cytochrome P-450 1A1 and GST enzymes. Cancer Causes Control, 15, 1077-83. https://doi.org/10.1007/s10552-004-2233-3
  38. Ruzzo A, Canestrari E, Maltese P, et al (2007). Polymorphisms in genes involved in DNA repair and metabolism of xenobiotics in individual susceptibility to sporadic diffuse gastric cancer. Clin Chem Lab Med, 45, 822-8.
  39. Saadat I, Saadat M (2001). Glutathione S-transferase M1 and T1 null genotypes and the risk of gastric and colorectal cancers. Cancer Lett, 169, 21-6. https://doi.org/10.1016/S0304-3835(01)00550-X
  40. Setiawan VW, Zhang ZF, Yu GP, et al (2000). GSTT1 and GSTM1 null genotypes and the risk of gastric cancer: a case-control study in a Chinese population. Cancer Epidemiol Biomarkers Prev, 9, 73-80.
  41. Setiawan VW, Zhang ZF, Yu GP, et al (2001). GSTP1 polymorphisms and gastric cancer in a high-risk Chinese population. Cancer Causes Control, 12, 673-81. https://doi.org/10.1023/A:1011261602940
  42. Shen J, Wang RT (2002). Case-control study of the polymorphisms of phase I and phase II metabolic genes and stomach cancer susceptibility. Tumor Jan, 1, 9-12. https://doi.org/10.1177/03008916020016s103
  43. Shen XB, Pu YP, Zhang J (2005). Influence of GSTT1 and GSTM1 genotypes and smoking ,alcohol exposure on the occurrence of gastric cancer: case-control study from Nanjing, China. J Environ Occup Med, 4, 325-9.
  44. Shen XB, Zhang J, Zhu LJ (2004). Relationship between glutathione S- transferase M1, T1 genetic polymorphisms, smoking and alcohol consumption and susceptibility and stomach cancer. School Public Health, 4, 2010-4.
  45. Shi JQ, Luo BJ, Liu RY (2014). Relationship of GSTT1 gene polymorphism and smoking on the susceptibility to gastric cancer. China Medical Herald, 2, 63-66.
  46. Sreeja L, Syamala V, Hariharan S, et al (2008). Glutathione S-transferase M1, T1 and P1 polymorphisms: susceptibility and outcome in lung cancer patients. J Exp Ther Oncol, 7, 73-85.
  47. Tamer L, Ates NA, Ates C, et al (2005). Glutathione S-transferase M1, T1 and P1 genetic polymorphisms, cigarette smoking and gastric cancer risk. Cell Biochem Funct, 23, 267-72. https://doi.org/10.1002/cbf.1148
  48. Trajkov D, Stardelova K, Dimitrova M, et al (2007). Helicobacter pylori and gastric carcinoma. Prilozi, 28, 39-46.
  49. Tripathi S, Ghoshal U, Ghoshal UC, et al (2008). Gastric carcinogenesis: Possible role of polymorphisms of GSTM1, GSTT1, and GSTP1 genes. Scand J Gastroenterol, 43, 431-9. https://doi.org/10.1080/00365520701742930
  50. Tripathi S, Ghoshal U, Mittal B, et al (2011). Association between gastric mucosal glutathione-S-transferase activity, glutathione-S-transferase gene polymorphisms and Helicobacter pylori infection in gastric cancer. Indian J Gastroenterol, 30, 257-63. https://doi.org/10.1007/s12664-011-0144-2
  51. Wang Q, Chen Y, Zhang Y, et al (2014). Quantitative assessment of the influence of glutathione S-transferase T1 null variant on gastric cancer risk. Tumour Biol, 35, 849-58. https://doi.org/10.1007/s13277-013-1118-z
  52. Wideroff L, Vaughan TL, Farin FM, et al (2007). GST, NAT1, CYP1A1 polymorphisms and risk of esophageal and gastric adenocarcinomas. Cancer Detect Prev, 31, 233-6. https://doi.org/10.1016/j.cdp.2007.03.004
  53. Wu MS, Chen CJ, Lin MT, et al (2002). Genetic polymorphisms of cytochrome p450 2E1, glutathione S-transferase M1 and T1, and susceptibility to gastric carcinoma in Taiwan. Int J Colorectal Dis, 17, 338-43. https://doi.org/10.1007/s00384-001-0383-2
  54. Xie SQ, Huang X, Lu YF (2008). Glutathione sulfur transferase t1, m1 gene deletion and wine and tobacco habit and gastric cancer susceptibility in the Guangxi people. Clinical Focus. 19, 1393-5.
  55. Yadav D, Chandra R, Saxena R, et al (2011). Glutathione-S-transferase M1 and T1 genes and gastric cancer: a case control study in North Indian population. Gene, 487, 166-9. https://doi.org/10.1016/j.gene.2011.07.010
  56. Yadav DS, Devi TR, Ihsan R, et al (2010). Polymorphisms of glutathione-S-transferase genes and the risk of aerodigestive tract cancers in the Northeast Indian population. Genet Test Mol Biomarkers, 14, 715-23. https://doi.org/10.1089/gtmb.2010.0087
  57. Ye M, Liu JY, Deng CJ (2003). Relationship between xenobioticmetabolizing enzyme gene polymorphisms and genetic susceptibility of gastric cancer. World Chin J Digestol, 9, 1314-7.
  58. Zendehdel K, Bahmanyar S, McCarthy S, et al (2009). Genetic polymorphisms of glutathione S-transferase genes GSTP1, GSTM1, and GSTT1 and risk of esophageal and gastric cardia cancers. Cancer Causes Control, 20, 2031-8. https://doi.org/10.1007/s10552-009-9399-7
  59. Zhang AP, Liu BH, Wang L, et al (2011). Glutathione S-transferase gene polymorphisms and risk of gastric cancer in a Chinese population. Asian Pac J Cancer Prev, 12, 3421-5.
  60. Zhang W, Huang J, Peng G, et al (2013). Null genotype of glutathione S-transferase T1 contributes to increased risk of gastric cancer in Asian population. Tumour Biol, 34, 1461-6. https://doi.org/10.1007/s13277-013-0669-3
  61. Zhang YC, Deng CS, Zhou Y (2003). Association of glutathione Stransferase M1 and T1 genetic polymorphisms with Helicobacter pylori infection and gastric adenocarcinoma. World Chin J Digestol, 9, 1306-9.
  62. Zheng TR, Zheng QH, Gong FS (2002). Gene deletion polymorphisms of GSTT1 and GSTM1 and susceptibility to stomach neoplasm. Shi Yong Zhong Liu Za Zhi, 3, 155-7.
  63. Zhou Q, Zheng ZY, Wang LD, et al (2003). Prevalence of genetic polymorphisms of GSTM1, GSTT1 and GSTP1 in subjects with gastric cardia adenocarcinoma at Linzhou, Henan. J Henan Med University, 3, 327-9.