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The Neutrophil to Lymphocyte Ratio is an Independent Prognostic Factor in Patients with Metastatic Gastric Cancer

  • Musri, Fatma Yalcin ;
  • Mutlu, Hasan ;
  • Eryilmaz, Melek Karakurt ;
  • Salim, Derya Kivrak ;
  • Gunduz, Seyda ;
  • Coskun, Hasan Senol
  • Published : 2016.04.11

Abstract

Inflammation can play an important role in cancer progression and the prognostic importance of neutrophil to lymphocyte ratio (NLR), a marker of inflammation, in cancer is a current investigation topic. In the present study, we aimed to determine whether there is a prognostic link between NLR and metastatic gastric cancer (mGC). A total of 143 patients from the Akdeniz University and Antalya Training and Research Hospital database were retrospectively analyzed. The median NLR value was 3.34. The median overall survival (OS) and median progression-free survival (PFS) were 11.6 and 7.9 months, respectively, in patients with NLR<3.34 while these values were 8.3 and 6.2 months respectively in patients with NLR>3.34 (p<0.001 and p=0.011, respectively). Our study showed that increased NLR is an independent prognostic factor associated with short survival in patients with mGC.

Keywords

Gastric cancer;neutrophil-to-lymphocyte ratio;progression-free survival;overall survival

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  1. Pre-treatment Peripheral Neutrophil-Lymphocyte Ratio as a Prognostic Marker in Gastric Cancer pp.1941-6636, 2018, https://doi.org/10.1007/s12029-018-0144-x
  2. Clinicopathological and prognostic significance of high circulating lymphocyte ratio in patients receiving neoadjuvant chemotherapy for advanced gastric cancer vol.8, pp.1, 2018, https://doi.org/10.1038/s41598-018-24259-5