Effects of Colpomenia sinuosa Extract on Serum Lipid Level and Bone Formation in Ovariectomized Rats

불레기말 추출물이 난소를 절제한 갱년기 장애 모델의 혈청 지질 변화 및 골 형성에 미치는 영향

  • 이주영 (신라대학교 식품영양학과) ;
  • 김보경 (신라대학교 식품영양학과) ;
  • 박미화 (신라대학교 식품영양학과) ;
  • 최경하 (신라대학교 식품영양학과) ;
  • 공창숙 (신라대학교 식품영양학과) ;
  • 이상현 (신라대학교 바이오산업학부 제약공학전공) ;
  • 김육용 ((주)이삭에프앤비) ;
  • 유기환 ((주)이삭에프앤비) ;
  • 김미향 (신라대학교 식품영양학과)
  • Received : 2016.02.23
  • Accepted : 2016.03.28
  • Published : 2016.04.30


In this study, the effects of Colpomenia sinuosa (CS) extract on serum lipid level and bone formation in an ovariectomized animal model were investigated. Twenty four nine-week old female Sprague-Dawley rats were randomly assigned to four groups: sham-operated rats (SHAM), ovariectomized control rats (OVX-CON), and ovariectomized rats supplemented with CS extract at 50 mg/kg bw (OVX-CS50) or 200 mg/kg bw (OVX-CS200). Three OVX groups were surgically ovariectomized while the SHAM group was sham-operated. CS extract was orally administrated at 1 mL per day. Analysis of serum lipid contents found that the total cholesterol, triglyceride, and low density lipoprotein cholesterol levels in the OVX-CON group were higher than those in the SHAM group. Notably, upon administration of CS extract after ovariectomy, triglyceride levels tended to significantly decrease. In addition, platelet aggregation ability decreased in groups treated with CS extract compared to the OVX-CON group. Serum alkaline phosphatase activity as an indicator of bone formation was lower in the CS extract group compared to the OVX-CON group. Collagen contents in bone and cartilage were reduced by ovariectomy, whereas the CS extract-supplemented groups exhibited higher concentrations in bone. According to these results, CS extract improved serum lipid parameters and osteogenesis in ovariectomized rats.


Supported by : 한국연구재단


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