Anti-Atopic Effects of Mixed Extracts from Date Plum, Persimmon, and Mulberry Leaves

고욤잎, 감잎 및 뽕잎 복합추출물의 항아토피 효과

  • 조병옥 ((주)아토큐앤에이 부설연구소) ;
  • 윤홍화 ((주)아토큐앤에이 부설연구소) ;
  • 신재영 (전주대학교 보건관리학과) ;
  • 방숭주 (전주대학교 보건관리학과) ;
  • 체 데니스 창 (전주대학교 보건관리학과) ;
  • 장선일 ((주)아토큐앤에이 부설연구소)
  • Received : 2015.12.11
  • Accepted : 2016.01.28
  • Published : 2016.04.30


The present study investigated the anti-atopic effects of mixed extracts from date plum, persimmon, and mulberry leaves (DPME) on atopic dermatitis (AD)-like skin lesions in hairless mice. The in vivo results demonstrated that DPME treatment significantly reduced the dermatitis clinical score and epidermal thickness in AD-like skin lesions. Histological analyses showed that DPME treatment strongly inhibited dermal infiltration of inflammatory cells and activity of mast cells in AD-like skin lesions. DPME treatment inhibited production of serum IgE and interluekin (IL)-4 in hairless mice with AD. Moreover, DPME treatment significantly suppressed production of tumor necrosis factor $(TNF)-{\alpha}$ and IL-6 cytokines in phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated HMC-1 human mast cells. In addition, DPME treatment reduced production of pro-inflammatory mediators (nitric oxide, prostaglandin E2, $TNF-{\alpha}$, and IL-6) in lipopolysaccharide-stimulated RAW 264.7 macrophages. Therefore, the results of this study indicate that the anti-atopic and anti-inflammatory effects of DPME may be involved in the regulation of inflammatory responses, suggesting that DPME may be used as an anti-atopic dermatitis material and natural anti-inflammatory ingredient.


Grant : 식물 유래 암갈색 색소 제거기술을 활용한 기능성 물질 고 함유 화장품 개발

Supported by : 중소기업청


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