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Anti-Allergic Effect of 1,2,3,4,6-Penta-O-Galloyl-β-D-Glucose on RBL-2H3 Cells

RBL-2H3 세포에서 1,2,3,4,6-Penta-O-Galloyl-β-D-Glucose의 항알레르기 효과

  • Kim, Yoon Hee (Department of Food and Nutrition, College of Engineering, Daegu University) ;
  • Choi, Ye Rang (Department of Food and Nutrition, College of Engineering, Daegu University) ;
  • Kim, Ji Young (Department of Food and Nutrition, College of Engineering, Daegu University) ;
  • Kwak, Sang Hee (Department of Food and Nutrition, College of Engineering, Daegu University)
  • 김윤희 (대구대학교 식품영양학과) ;
  • 최예랑 (대구대학교 식품영양학과) ;
  • 김지영 (대구대학교 식품영양학과) ;
  • 곽상희 (대구대학교 식품영양학과)
  • Received : 2015.11.30
  • Accepted : 2016.01.20
  • Published : 2016.04.30

Abstract

1,2,3,4,6-Penta-O-galloyl-${\beta}$-D-glucose (PGG) is a gallotannin isolated from various plants such as Galla Rhois. In a previous study, it was reported that PGG has anti-allergic effects by inhibiting interleukin (IL)-4 signaling in B cells. However, the effect of PGG on basophilic cells remains unclear. Therefore, the aim of this study was to investigate the inhibitory effect of PGG on mitogen and calcium ionophore-induced allergic responses. PGG had no effect on proliferation and cytotoxicity of RBL-2H3 cells. PGG significantly suppressed cell degranulation (histamine and ${\beta}-hexosaminidase$) as well as inflammatory cytokine production such as IL-4 and tumor necrosis factor-${\alpha}$. The underlying mechanism of PGG on these anti-allergic actions was correlated with inhibition on translocation of nuclear factor-${\kappa}B$ from the cytosol to nucleus. These data suggest that PGG is a potentially effective functional compound for prevention of allergic diseases.

Acknowledgement

Supported by : 한국과학창의재단

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