천마(天麻)의 국내,외 연구동향과 『본초학』, 한국표준질병사인분류의 상관관계에 대한 체계적 문헌고찰

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김현석;이숭인;정종길
Kim, Hyun-Seok;Lee, Soong-In;Jeong, Jong-Kil

  • 투고 : 2016.01.21
  • 심사 : 2016.03.24
  • 발행 : 2016.03.30

초록

Objectives : The study was aimed to analyze the correlation between Herbology and contemporary research results, KCD-codes and terms. The study will present information that can be used to find the direction of further researches and be applied to the education of Herbology.Methods : Papers were searched in OASIS and PubMed. Papers were then categorized as "medicine and pharmacy articles" or "articles unrelated to medicine and pharmacy." Medicine or pharmacy articles about Gastrodiae Rhizoma were matched with treatments in Herbology and KCD-codes. Medicine and pharmacy articles which did not research Gastrodiae Rhizoma mainly and articles unrelated to medicine and pharmacy were categorized and analyzed. KCD-codes and terms were arranged by treatments in Herbology. Research types, the number of papers, and the citation count were arranged by each treatment in Herbology. Degrees of Herbology research were represented as a table and a graph.Results : There were 148 Medicine and pharmacy articles about Gastrodiae Rhizoma, 76 medicine and pharmacy articles which did not studied Gastrodiae Rhizoma mainly, and 120 articles unrelated to medicine and pharmacy. Researches on Senility and hypertensive diseases were conducted to the degree of clinical research. Numbness of the limbs scored 617, Epilepsy and convulsions scored 257.Conclusions : The study suggests that there were 148 medicine and pharmacy articles about Gastrodiae Rhizoma. Epilepsy and convulsions were the most researched treatment in Herbology. Of the medicine and pharmacy articles tha t did not match treatments in Herbology, there were clinical research articles researching on senility which can be used in the Herbology education field.

키워드

Gastrodiae Rhizoma;Herbal Medicine;Epilepsy;Brain Ischemia;Dementia;Review Literature as Topic

참고문헌

  1. The Ministry of Food and Drug Safety. Herbal Medicine Database. Avaliable from : URL : http://www.mfds.go.kr/herbmed/index.do?code=KP-021&nMenuCode=7&includeUrl=/herbmed/view.jsp
  2. Pharmacopoeia Commission of the People's Republic of China. Pharmacopoeia of the People's Republic of China. Beijing : China Medical Science and Technology Press. 2010 : 354.
  3. Kim IS, Lee YJ. A Study on the Utilization and Efficacy of Gastrodiae Elatae Rhizoma. J Korean Med Kyungwon Univ. 2005 ; 9(1) : 11-23.
  4. Herbology Editorial Committee of Korean Medicine schools. Boncho-hak. Seoul : Young-Lim Press. 2004 : 104, 543.
  5. Kim YH, Seo BI. A philological study on poisoning and side effects of Gastrodiae Rhizoma(天麻). J Jeahan Orient Med Aca. 2012 ; 10(1) : 137-45.
  6. Kim DH, Kim HY, Jang EY, Yang CH, Roh SS. The study on chemical components and korean medical effects of Gastrodiae Rhizoma. J East-West Med. 2012 ; 37(3) : 41-55.
  7. Kim DH, Kim HY, Jang EY, Yang CH, Roh SS. The study on chemical components and korean medical effects of Gastrodiae Rhizoma. J East-West Med. 2012 ; 37(3) : 41-55.
  8. Lee IS. Korean Standard Classification of Disease. Seoul : Statistics Korea. 2010 : 20.
  9. Kim HS, Jeong JK, Lee SI. The Literature Study of Research Trend of Menthae Herba and Relationship Between the Herbology and KCD-code. Korea J Herbol. 2015 ; 30(5) : 29-43. https://doi.org/10.6116/kjh.2015.30.5.29.
  10. Qiu F, Liu TT, Qu ZW, Qiu CY, Yang Z, Hu WP. Gastrodin inhibits the activity of acid-sensing ion channels in rat primary sensory neurons. Eur J Pharmacol. 2014 ; 731 : 50-7. https://doi.org/10.1016/j.ejphar.2014.02.044
  11. Luo GG, Fan WJ, Yuan XY, Yuan BB, Lü SM, Cao YX, Xu CB. The pharmacological mechanism of gastrodin on calcitonin gene-related peptide of cultured rat trigeminal ganglion. Acta pharmaceutica Sinica. 2011 ; 46(12) : 1451-6.
  12. Yoon T, Kang GY, Han AR, Seo EK, Lee YS. 2,4-Bis (4-hydroxybenzyl) phenol inhibits heat shock transcription factor 1 and sensitizes lung cancer cells to conventional anticancer modalities. J Nat Prod. 2014 ; 77(5) : 1123-9. https://doi.org/10.1021/np4009333
  13. Chen X, Xiao F, Wang Y, Fang J, Ding K. Structure-activity relationship study of WSS25 derivatives with anti-angiogenesis effects. Glycoconjugate J. 2012 ; 29(5-6) : 389-98. https://doi.org/10.1007/s10719-012-9424-z
  14. Hwang SM, Lee YJ, Kang DG, Lee HS. Antiinflammatory effect of Gastrodia elata rhizome in human umbilical vein endothelial cells. Am J Chin Med. 2009 ; 37(2) : 395-406. https://doi.org/10.1142/S0192415X09006916
  15. Heo JC, Woo SU, Son MS, Park JY, Choi WS, Chang KT, Kim SU, Yoon EK, Shin HM, Lee SH. Anti-tumor activity of Gastrodia elata Blume is closely associated with a GTP-Ras-dependent pathway. Oncol Rep. 2007 ; 18(4) : 849-53.
  16. Lee YJ, Hwang SM, Kang DG, Kim JS, Lee HS. Effect of Gastrodia elata on tumor necrosis factor-alpha-induced matrix metalloproteinase activity in endothelial cells. J Nat Med. 2009 ; 63(4) : 463-7. https://doi.org/10.1007/s11418-009-0352-6
  17. Wang XD, Zeng S. The transport of gastrodin in Caco-2 cells and uptake in Bcap37 and Bcap37 /MDR1 cells. Yao Xue Xue Bao. 2010 ; 45 : 1497-502.
  18. Qiu H, Tang W, Tong X, Ding K, Zuo J. Structure elucidation and sulfated derivatives preparation of two α-d-glucans from Gastrodia elata Bl. and their anti-dengue virus bioactivities. Carbohydrate Res. 2007 ; 342(15) : 2230-6. https://doi.org/10.1016/j.carres.2007.06.021
  19. Tong XK, Qiu H, Zhang X, Shi LP, Wang GF, Ji FH, Ding HY, Tang W, Ding K, Zuo JP. WSS45, a sulfated α-D-glucan, strongly interferes with Dengue 2 virus infection in vitro. Acta Pharmacologica Sinica. 2010 ; 31(5) : 585-92. https://doi.org/10.1038/aps.2010.29
  20. Kim HJ, Lee JH, Shin MK, Hyun LK, Kim YJ, Lee MH. Inhibitory effect of Gastrodia elata extract on melanogenesis in HM3KO melanoma cells. J Cosmetic Sci. 2012 ; 64(2) : 89-98.
  21. Pyo MK, Jin JL, Koo YK, Yun-Choi HS. Phenolic and furan type compounds isolated from Gastrodia elata and their anti-platelet effects. Arc Pharm Res. 2004 ; 27(4) : 381-5. https://doi.org/10.1007/BF02980077
  22. Choi YS, Lee EM, Son YW, Lee KC, Shin YI, Song MS, Choi YJ, Choi GC, Kang HW, Lim CY, Ryu JY, Park SH, Park ST. Cytotoxicity of hydrogen peroxide and effects of Rhizoma Gastrodiae against hydrogen peroxide in mouse cerebral neurons. Korean J Orient Physiol Pathol. 2002 ; 16(5) : 928-31.
  23. Ding CS, Shen YS, Li G, Wei Z, Wei F. Study of a glycoprotein from Gastrodia elata: its effects of anticoagulation and antithrombosis. Zhongguo Zhong Yao Za Zhi. 2007 ; 32(11) : 1060-4.
  24. Heo YH, Choi NH, Seo YK, Jang JY, Lee JH, Kyu KJ, Choi BT. Anti-inflammatory Effects of Gastrodia elata Extract in Lipopolysaccharide-stimulated BV-2 Microglia Cell. J Orient Physio Pathol. 2012 ; 26(5) : 738-44.
  25. Jiankang L, Akitane M. Antioxidant and pro-oxidant activities of p-hydroxybenzyl alcohol and vanillin: effects on free radicals, brain peroxidation and degradation of benzoate, deoxyribose, amino acids and DNA. Neuropharmacology. 1993 ; 32(7) : 659-69. https://doi.org/10.1016/0028-3908(93)90079-I
  26. Song HJ, Lee YS, Son YW, Lee GC, Jeong JG, Sin MG, Hong GY. Effect of Glucose oxidase and Effect of Gastrodiae Rhizoma on Glucose Oxidase in Spinal Sensory Ganglion Neurons. Korea J Herbol. 2002 ; 17(2) : 125-31.
  27. Son IH, Lee JH, Kim SS, Lee GC, Lee YM, Hong GY, Moon YB, Seo EA, Han DS, Sin MK, Song HK, Park ST. Effects of Rhizoma Gastrodiae on Cultured Spinal Motor Neurons Damaged by Hydrogen Peroxide. Korean J Orient Physiol Pathol. 2002 ; 16(2) : 262-6.
  28. Choi YS, Lee EM, Min BG, Hong GY, Kim YI, Jo WJ, Jeong YM, Lee GM, Ok SI, Lee GC, Park ST. Effect of Rhizoma Gastrodiae on Xanthine Oxidase and Hypoxanthine in Cultured Schwann Cells. J Orient Physio Pathol. 2001 ; 15(5) : 794-8.
  29. Kim HS, Lee YS, Lee HB, Son IB, Lee JG, Son YW, Lee JH, Lee GC, Ryu MH, Song HJ, Seong GK, Park ST, Lee GS, Ryu DG. Effects of Rhizoma Gastrodiae on Cultured Mouse Spinal Motor Neurons Damaged by Hydrogen Peroxide. Korean J Orient Physiol Pathol. 2002 ; 16(1) : 150-3.
  30. Lee GH, Kim HR, Han SY, Bhandary B, Kim DS, Kim MG, So BO, Kim SY, Jo KS, Lee BH, Seo HN, Chae SW, Chae HJ. Gastrodia elata Blume and its pure compounds protect BV-2 microglial-derived cell lines against β-amyloid: The involvement of GRP78 and CHOP. Biol Res. 2012 ; 45(4) : 403-10. https://doi.org/10.4067/S0716-97602012000400013
  31. Park ST, Yoon HS, Hong GY, Lee HS, Park BL. Effects of Rhizoma Gastrodiae on Oxidant-Induced Neurotoxicity in Oligodendrocyte. Korean J Orient Physiol Pathol. 1999 ; 13(1) : 104-7.
  32. Kim HJ, Moon KD, Lee DS, Lee SH. Ethyl ether fraction of Gastrodia elata Blume protects amyloid β peptide-induced cell death. J Ethnopharmacology. 2003 ; 84(1) : 95-8. https://doi.org/10.1016/S0378-8741(02)00290-8
  33. Dong XX, Liu JB, Dong YX. Experimental study on effect of gastrodia in inducing the differentiation of mesenchymal stem cells into neuron-like cells. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 ; 24(1) : 51-4.
  34. Manavalan A, Ramachandran U, Sundaramurthi H, Mishra M, Sze SK, Hu JM, Feng JW, Heese K. Gastrodia elata Blume (tianma) mobilizes neuroprotective capacities. Int J Biochem Mol Biol. 2012 ; 3(2) : 219-41.
  35. Huang CL, Yang JM, Wang KC, Lee YC, Lin YL, Yang YC, Huang NK. Gastrodia elata prevents huntingtin aggregations through activation of the adenosine A 2A receptor and ubiquitin proteasome system. J Ethnopharmacology. 2011 ; 138(1) : 162-8. https://doi.org/10.1016/j.jep.2011.08.075
  36. Huang NK, Lin YL, Cheng JJ, Lai WL. Gastrodia elata prevents rat pheochromocytoma cells from serum-deprived apoptosis: the role of the MAPK family. Life Sci. 2004 ; 75(13) : 1649-57. https://doi.org/10.1016/j.lfs.2004.05.008
  37. Han YJ, Je JH, Kim SH, Ahn SM, Kim HN, Kim YR, Choi YW, Shin HK, Choi BT. Gastrodia elata Shows Neuroprotective Effects via Activation of PI3K Signaling against Oxidative Glutamate Toxicity in HT22 Cells. Am J Chin Med. 2014 ; 42(4) : 1007-19. https://doi.org/10.1142/S0192415X14500633
  38. Lee YS, Ha JH, Yong CS, Lee DU, Huh K, Kang YS, Lee SH, Jung MW, Kim JA. Inhibitory effects of constituents of Gastrodia elata Bl. on glutamate-induced apoptosis in IMR-32 human neuroblastoma cells. Arc Pharm Res. 1999 ; 22(4) : 404-9. https://doi.org/10.1007/BF02979066
  39. Jiang G, Hu Y, Liu L, Cai J, Peng C, Li Q. Gastrodin protects against MPP+-induced oxidative stress by up regulates heme oxygenase-1 expression through p38 MAPK/Nrf2 pathway in human dopaminergic cells. Neurochem Int. 2014 ; 75 : 79-88. https://doi.org/10.1016/j.neuint.2014.06.003
  40. Jiang G, Wu H, Hu Y, Li J, Li Q. Gastrodin inhibits glutamate-induced apoptosis of PC12 cells via inhibition of CaMKII/ASK-1/p38 MAPK/p53 signaling cascade. Cel Mol Neurobiol. 2014 ; 34(4) : 591-602. https://doi.org/10.1007/s10571-014-0043-z
  41. Ha JH, Shin SM, Lee SK, Kim JS, Shin US, Huh K, Kim JA, Yong CS, Lee NJ, Lee D U. In vitro effects of hydroxybenzaldehydes from Gastrodia elata and their analogues on GABAergic neurotransmission, and a structure-activity correlation. Planta Medica. 2001 ; 67(9) : 877-80. https://doi.org/10.1055/s-2001-18844
  42. Kim BW, Koppula S, Kim JW, Lim HW, Hwang JW, Kim IS, Park PJ, Choi DK. Modulation of LPS-stimulated neuroinflammation in BV-2 microglia by Gastrodia elata: 4-hydroxybenzyl alcohol is the bioactive candidate. J Ethnopharmacology. 2012 ; 139(2) : 549-57. https://doi.org/10.1016/j.jep.2011.11.048
  43. Kim IS, Choi DK, Jung HJ. Neuroprotective effects of vanillyl alcohol in Gastrodia elata Blume through suppression of oxidative stress and anti-apoptotic activity in toxin-induced dopaminergic MN9D cells. Molecules. 2011 ; 16(7) : 5349-61. https://doi.org/10.3390/molecules16075349
  44. Huang NK, Chern Y, Fang JM, Lin CI, Chen WP, Lin YL. Neuroprotective principles from Gastrodia elata. J Nat Prod. 2007 ; 70(4) : 571-4. https://doi.org/10.1021/np0605182
  45. Sundaramurthi H, Manavalan A, Ramachandran U. Hu JM, Sze SK, Heese K. Phenotyping of tianma-stimulated differentiated rat neuronal b104 cells by quantitative proteomics. Neurosignals. 2012 ; 20(1) : 48-60. https://doi.org/10.1159/000331492
  46. Tsai CF, Huang CL, Lin YL, Lee YC, Yang YC, Huang NK. The neuroprotective effects of an extract of Gastrodia elata. J Ethnopharmacology. 2011 ; 138(1) : 119-25. https://doi.org/10.1016/j.jep.2011.08.064
  47. An H, Kim, IS, Koppula S, Kim BW, Park, PJ, Lim BO, Choi WS, Lee KH, Choi DK. Protective effects of Gastrodia elata Blume on MPP+-induced cytotoxicity in human dopaminergic SH-SY5Y cells. J Ethnopharmacology. 2010 ; 130(2) : 290-8. https://doi.org/10.1016/j.jep.2010.05.006
  48. Xu X, Lu Y, Bie X. Protective effects of gastrodin on hypoxia-induced toxicity in primary cultures of rat cortical neurons. Planta Medica. 2007 ; 73(7) : 650-4. https://doi.org/10.1055/s-2007-981523
  49. Ng CF, Ko CH, Koon CM, Xian JW, Leung PC. Fung KP, Edwin Chan HY, Lau CB. The aqueous extract of rhizome of Gastrodia elata protected Drosophila and PC12 cells against beta-amyloid-induced neurotoxicity. Evid Based Complement Alternat Med. 2013 ; 2012 : 516741.
  50. Huang ZB, Wu Z, Chen FK, Zou LB. The protective effects of phenolic constituents from Gastrodia elata on the cytotoxicity induced by KCl and glutamate. Arc Pharm Res. 2006 ; 29(11) : 963-8. https://doi.org/10.1007/BF02969279
  51. Ramachandran U, Manavalan A, Sundaramurthi H, Sze SK, Feng ZW, Hu JM, Heese K. Tianma modulates proteins with various neuro-regenerative modalities in differentiated human neuronal SH-SY5Y cells. Neurochem Int. 2012 ; 60(8) : 827-36. https://doi.org/10.1016/j.neuint.2012.03.012
  52. Zhang ZC, Su G, Li J, Wu H, Xie XD. Two new neuroprotective phenolic compounds from Gastrodia elata. J Asian Nat Prod Res. 2013 ; 15(6) : 619-23. https://doi.org/10.1080/10286020.2013.791286
  53. Choi YH, Song JH, Jang SJ, Kim Jk, Choi MK. Effects of Gastrodia elata Blume Water Extract on RANKL-induced Osteoclast Differentiation. Korean J Orient Physiol Pathol. 2010 ; 24(5) : 807-13.
  54. Jang YW, Lee JY, Kim CJ. Anti-asthmatic activity of phenolic compounds from the roots of Gastrodia elata Bl. Int Immunopharmacol. 2010 ; 10(2) : 147-54. https://doi.org/10.1016/j.intimp.2009.10.009
  55. Chen C, Qin Y, Fang JP, Ni XY, Yao J, Wang HY, Ding K. WSS25, a sulfated polysaccharide, inhibits RANKL-induced mouse osteoclast formation by blocking SMAD/ID1 signaling. Acta Pharmacologica Sinica. 2015 ; 36(9) : 1053-64. https://doi.org/10.1038/aps.2015.65
  56. Hayashi J, Sekine T, Deguchi S, Lin Q, Horie S, Tsuchiya S, Shingo Y, Kazuo W, Ikegami F. Phenolic compounds from Gastrodia rhizome and relaxant effects of related compounds on isolated smooth muscle preparation. Phytochemistry. 2002 ; 59(5) : 513-9. https://doi.org/10.1016/S0031-9422(02)00008-0
  57. World Health Organization. WHO International Standard Terminologies on Traditional Medicine in the Western Pacific Region. Manila : WHO Regional Office for the Western Pacific. 2007 : 82, 92, 166, 167, 184, 191, 192.
  58. Kim KJ, Lee OH, Han CK, Kim YC, Hong HD. Acidic Polysaccharide Extracts from Gastrodia Rhizomes Suppress the Atherosclerosis Risk Index through Inhibition of the Serum Cholesterol Composition in Sprague Dawley Rats Fed a High-Fat Diet. Int J Mol Sci. 2012 ; 13(2) : 1620-31. https://doi.org/10.3390/ijms13021620
  59. Zhang F, Li A. Dual restoring effects of gastrodin on dopamine in rat models of Tourette’s syndrome. Neurosci Lett. 2015 ; 588 : 62-6. https://doi.org/10.1016/j.neulet.2014.12.051
  60. Lee HE, Lee YW, Park SJ, Jeon SJ, Kim EJ, Lee SH, Han AR, Seo EK, Ryu JH. 4-Hydroxybenzyl methyl ether improves learning and memory in mice via the activation of dopamine D1 receptor signaling. Neurobiol Learn Mem. 2015 ; 121 : 30-8. https://doi.org/10.1016/j.nlm.2015.03.004
  61. Chen PJ, Liang KC, Lin HC, Hsieh CL, Su KP, Hung MC, Sheen LY. Gastrodia elata Bl. Attenuated learning deficits induced by forced-swimming stress in the inhibitory avoidance task and Morris water maze. J Med Food. 2011 ; 14(6) : 610-7. https://doi.org/10.1089/jmf.2010.1209
  62. Huang GB, Zhao T, Muna SS, Jin HM, Park JI, Jo KS, Lee BH, Chae SW, Kim SY, Park SH, Park EO, Choi EK. Therapeutic potential of Gastrodia elata Blume for the treatment of Alzheimer's disease. Neural Regen Res. 2013 ; 8(12) : 1061-70.
  63. Mishra M, Huang J, Lee YY, Chua DSK, Lin X, Hu JM, Heese K. Gastrodia elata modulates amyloid precursor protein cleavage and cognitive functions in mice. Biosci Trends. 2011 ; 5(3) : 129-38. https://doi.org/10.5582/bst.2011.v5.3.129
  64. Hu Y, Li C, Shen W. Gastrodin alleviates memory deficits and reduces neuropathology in a mouse model of Alzheimer's disease. Neuropathology. 2014 ; 34(4) : 370-7.
  65. Hsieh MT, Wu CR, Chen CF. Gastrodin and p-hydroxybenzyl alcohol facilitate memory consolidation and retrieval, but not acquisition, on the passive avoidance task in rats. J Ethnopharmacology. 1997 ; 56(1) : 45-54. https://doi.org/10.1016/S0378-8741(96)01501-2
  66. Shin EJ, Bach JH, Nguyen TT, Nguyen XK, Jung BD, Oh KW, Kim MJ, Ko SK, Jang CG, Ali SF, Kim HC. Gastrodia elata bl attenuates methamphetamine-induced dopaminergic toxicity via inhibiting oxidative burdens. Curr Neuropharmacol. 2011 ; 9(1) : 118-21. https://doi.org/10.2174/157015911795016967
  67. Manavalan A, Ramachandran U, Sundaramurthi H, Mishra M, Sze SK, Hu JM, Feng JW, Heese K. Gastrodia elata Blume (tianma) mobilizes neuroprotective capacities. Int J Biochem Mol Biol. 2012 ; 3(2) : 219-41.
  68. Manavalan A, Feng L, Sze SK, Hu JM, Heese K. New insights into the brain protein metabolism of Gastrodia elata-treated rats by quantitative proteomics. J proteomics. 2012 ; 75(8) : 2468-79. https://doi.org/10.1016/j.jprot.2012.02.029
  69. Shuchang H, Qiao N, Piye N, Mingwei H, Xiaoshu S, Feng S, Sheng W, Opler M. Protective effects of gastrodia elata on aluminium-chloride-induced learning impairments and alterations of amino acid neurotransmitter release in adult rats. Restor Neurol Neurosci. 2008 ; 26(6) : 467-73.
  70. Li M, Hu J, Li G, Xie L. The antagonism of rhizoma gastrodiae to lead-induced damage of hippocampus in rats. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2002 ; 20(5) : 331-3.
  71. Wu CR, Hsieh MT, Huang SC, Peng WH, Chang YS, Chen CF. Effects of Gastrodia elata and its active constituents on scopolamine-induced amnesia in rats. Planta Medica. 1996 ; 62(4) : 317-21. https://doi.org/10.1055/s-2006-957892
  72. Wu CR, Hsieh MT, Liao J. p-Hydroxybenzyl alcohol attenuates learning deficits in the inhibitory avoidance task: involvement of serotonergic and dopaminergic systems. Chin J Physiol. 1995 ; 39(4) : 265-73.
  73. Park YM, Lee BG, Park SH, Oh HG, Kang YG, Kim OJ, Kwon LS, Kim YP, Choi MH, Jeong YS, Oh J, Lee HK. Prolonged oral administration of Gastrodia elata extract improves spatial learning and memory of scopolamine-treated rats. Lab Ani Res. 2015 ; 31(2) : 69-77. https://doi.org/10.5625/lar.2015.31.2.69
  74. Hu JF, Li GZ, Li MJ. The antagonistic action of Gastrodia elata combined with E-gelatin on lead-induced down regulation of c-fos expression in rat brain. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2003 ; 21(2) : 128-31.
  75. Niu Q, Niu P, He S. Effect of gastrodia elata on learning and memory impairment induced by aluminum in rats. JWei Sheng Yan Jiu. 2004 ; 33(1) : 45-8.
  76. Gao N, Yu S, Xu J. Improving effect of rhizoma Gastrodiae on learning and memory of senile rats. Zhongguo Zhong Yao Za Zhi. 1995 ; 20(9) : 562-3.
  77. Zhou BH, Li XJ, Liu M, Wu Z, Hu XM. Antidepressant-like activity of the Gastrodia elata ethanol extract in mice. Fitoterapia. 2006 ; 77(7) : 592-4. https://doi.org/10.1016/j.fitote.2006.06.016
  78. Lin SH, Chen WC, Lu KH, Chen PJ, Hsieh SC, Pan TM, Chen ST, Sheen LY. Down-regulation of Slit–Robo Pathway Mediating Neuronal Cytoskeletal Remodeling Processes Facilitates the Antidepressive-like Activity of Gastrodia elata Blume. J Agric Food Chem. 2014 ; 62(43) : 10493-503. https://doi.org/10.1021/jf503132c
  79. Sun W, Miao B, Wang XC, Duan JH, Ye X, Han WJ, Wang WT, Luo C, Hu SJ. Gastrodin inhibits allodynia and hyperalgesia in painful diabetic neuropathy rats by decreasing excitability of nociceptive primary sensory neurons. PLoS one. 2012 ; 7(6) : e39647. https://doi.org/10.1371/journal.pone.0039647
  80. Chen PJ, Hsieh CL, Su KP, Hou YC, Chiang HM, Sheen LY. Rhizomes of Gastrodia elata BL possess antidepressant-like effect via monoamine modulation in subchronic animal model. Am J Chin Med. 2009 ; 37(06) : 1113-24. https://doi.org/10.1142/S0192415X09007533
  81. Chen PJ, Hsieh CL, Su KP, Hou YC, Chiang HM, Lin IH, Sheen LY. The antidepressant effect of Gastrodia elata Bl. on the forced-swimming test in rats. Am J Chin Med. 2008 ; 36(1) : 95-106. https://doi.org/10.1142/S0192415X08005618
  82. Hong SS, Cho SH. Antidepressant-like Effects of the Gastrodia elata Bl Extract in Mice. J Orient Neuropsy. 2013 ; 24(3) : 281-92. https://doi.org/10.7231/jon.2013.24.3.281
  83. Sim KC. Effect of each Gastrodia elata Blume concentration on antidiabetic in diabetic mellitus rats. Korean J Orient Physiol Pathol. 2007 ; 21 : 1477-82.
  84. Shim KC, Kim EJ, Jeong HW, Kim GD, Kim GY, Kim KY. Effect of Prior Gastrodia elata Blume diet on Diabetic Mellitus Induced Rats at Antioxidant Effect and Pathophysiology factor. Korean J Orient Physiol Pathol. 2007 ; 21 : 1477-82.
  85. Kim EJ, Kim YU. Effect of Swimming Exercise Training and Gastrodia Elata Blume Extract Administration on Oxidative Enzyme Activity in Streptozotocin-induced Diabetic Rat. Korean J Orient Physiol. 2009 ; 23(6) : 1399-403.
  86. Ha JH, Lee DU, Lee JT, Kim JS, Yong CS, Kim JA, Ha JS, Keun H. 4-Hydroxybenzaldehyde from Gastrodia elata B1. is active in the antioxidation and GABAergic neuromodulation of the rat brain. J Ethnopharmacology. 2000 ; 73(1) : 329-33. https://doi.org/10.1016/S0378-8741(00)00313-5
  87. Hsieh CL, Lin JJ, Chiang SY, Su SY, Tang NY, Lin GG Lin IH, Liu CH, Hsiang CY, Chen JC, Ho TY. Gastrodia elata modulated activator protein 1 via c-Jun N-terminal kinase signaling pathway in kainic acid-induced epilepsy in rats. J Ethnopharmacology. 2007 ; 109(2) : 241-7. https://doi.org/10.1016/j.jep.2006.07.024
  88. Kim HJ, Moon KD, Oh SY, Kim SP, Lee SR. Ether fraction of methanol extracts of Gastrodia elata, a traditional medicinal herb, protects against kainic acid-induced neuronal damage in the mouse hippocampus. Neurosci Lett. 2001 ; 314(1) : 65-8. https://doi.org/10.1016/S0304-3940(01)02296-0
  89. Kim HJ, Moon KD, Oh SY, Kim SP, Lee SR. Ether fraction of methanol extracts of Gastrodia elata, a traditional medicinal herb, protects against kainic acid-induced neuronal damage in the mouse hippocampus. Neurosci Lett. 2001 ; 314(1) : 65-68. https://doi.org/10.1016/S0304-3940(01)02296-0
  90. Hsieh CL, Chen CL, Tang NY, Chuang CM, Hsieh CT, Chiang SY, Lin JG, Hsu SF. Gastrodia elata BL mediates the suppression of nNOS and microglia activation to protect against neuronal damage in kainic acid-treated rats. Am J Chin Med. 2005 ; 33(4) : 599-611. https://doi.org/10.1142/S0192415X0500320X
  91. Andersson M, Bergendorff O, Nielsen M, Sterner O, Witt R, Ai J, Lu A, Wang AM. Inhibition of kainic acid binding to glutamate receptors by extracts of Gastrodia. Phytochemistry. 1995 ; 38(4) : 835-6. https://doi.org/10.1016/0031-9422(94)00771-K
  92. An SJ, Park SK, Hwang IK, Choi SY, Kim SK, Kwon OS, Jung SJ, Baek NI, Lee HY, Won MH, Kang TC. Gastrodin decreases immunoreactivities of γ‐aminobutyric acid shunt enzymes in the hippocampus of seizure‐sensitive gerbils. J Neurosci Res. 2003 ; 71(4) : 534-43. https://doi.org/10.1002/jnr.10502
  93. Hsieh CL, Chiang SY, Cheng KS, Lin YH, Tang NY, Lee CJ, Pon CH, Hsieh CT. Anticonvulsive and free radical scavenging activities of Gastrodia elata Bl. in kainic acid-treated rats. Am J Chin Med. 2001 ; 29(2) : 331-41. https://doi.org/10.1142/S0192415X01000356
  94. Wu HQ, Xie L, Jin XN, Ge Q, Jin H, Liu GQ. The effect of vanillin on the fully amygdala-kindled seizures in the rat. Acta pharmaceutica Sinica. 1988 ; 24(7) : 482-6.
  95. Hsieh CL, Chang CH, Chiang SY, Li TC, Tang NY, Pon CZ, Hsieh CT, Lin JG. Anticonvulsive and free radical scavenging activities of vanillyl alcohol in ferric chloride-induced epileptic seizures in Sprague-Dawley rats. Life Sci. 2000 ; 67(10) : 1185-95. https://doi.org/10.1016/S0024-3205(00)00706-2
  96. Shin EJ, Bach JH, Nguyen TT, Jung BD, Oh KW, Kim MJ, Jang CG, Ali SF, Ko SK, Yang CH, Kim HC. Gastrodia Elata Bl attenuates cocaine-induced conditioned place preference and convulsion, but not behavioral sensitization in mice: importance of GABAA receptors. Curr Neuropharmacol. 2011 ; 9(1) : 26-35. https://doi.org/10.2174/157015911795017326
  97. Jung TY, Suh SI, Lee H, Kim IS, Kim HJ, Yoo HS, Lee SR. Protective effects of several components of Gastrodia elata on lipid peroxidation in gerbil brain homogenates. Phytother Res. 2007 ; 21(10) : 960-4. https://doi.org/10.1002/ptr.2193
  98. Park KW, Park DS, Kang SK. Studies on the Anti-Convulsive Effect Gastrodiae Rhizoma Aqua-Acupuncture. J KyungHee Orient Med College. 1988 ; 11 : 15-36.
  99. Sung EJ, Kim, HC, Ahn DK. A Study on the Antihypertensive Effect of Gastrodia. Korea J Herbol. 1997 ; 12(2) : 51-61.
  100. Teong IWJ, Ko AAR, Li M, Heese K, Liang W. Gastrodia elata decreases isoprenaline potency and enhances spontaneous phasic activity in the rat detrusor. Int J Physiol Pathophysiol Pharmacol. 2011 ; 3(1) : 29-37.
  101. Lee OH, Kim KI, Han CK, Kim YC, Hong HD. Effects of acidic polysaccharides from Gastrodia rhizome on systolic blood pressure and serum lipid concentrations in spontaneously hypertensive rats fed a high-fat diet. Int J Mol Sci. 2012 ; 13(1) : 698-709. https://doi.org/10.3390/ijms13010698
  102. Zhu L, Guan H, Cui C, Tian S, Yang D, Wang X, Zhang S, Wang L, Jiang, H. Gastrodin inhibits cell proliferation in vascular smooth muscle cells and attenuates neointima formation in vivo. Int J Mol Med. 2012 ; 30(5) : 1034-40. https://doi.org/10.3892/ijmm.2012.1100
  103. Yang JH, Kwen YZ, Kim MR. Effect of Gastrodiae Rhizoma Extract on Blood Pressure and Plasma Catecholamine Level in Unanaesthetized Spontaneously Hypertensive Rats. J Korean Orient Med. 1995 ; 16(2) : 433-46.
  104. Yang CH, Kim MR, Kwen YZ. Effect of Gastrodiae rhizoma extract on plasma levels of electrolytes and aldosterone and plasma renin activity in unaneshtetized spontaneously hypertensive rats. J East-West Med. 2001 ; 22 : 1-22.
  105. Kho MC, Lee YJ, Cha JD, Choi KM, Kang DG, Lee HS. Gastrodia elata ameliorates high-fructose diet-induced lipid metabolism and endothelial dysfunction. Evid Based Complement Alternat Med. 2014 ; 2014 : 101624. https://doi.org/10.1155/2014/101624
  106. Lee JY, Ku JS, Lee DE, Shin JW, Kim SJ, Sohn NW. Effects of Gastrodiae Rhizoma on Brain Edema and Aquaporin Expressions Following Intracerebral Hemorrhage in Rats. Korea J Herbol. 2010 ; 25(4) : 85-93.
  107. Song SH, Lee JS, Shin JW, Kim SJ, Sohn NW. An Immunohistochemical Study on Effect of Gastrodiae Rhizoma against Neuronal Apoptosis Following Intracerebral Hemorrhage in Rats. J Orient Rehabilitation Med. 2011 ; 21(4) : 1-12.
  108. Luo H, Wang L, Chen H, Xue Z. Effects of tian-ma injection on myocardial ischemia and lipid peroxidation in rabbits. J West China Univ Med Sci. 1992 ; 23(1) : 53-6.
  109. Liu Y, Tang X, Pei J, Zhang L, Liu F, Li KA. Gastrodin interaction with human fibrinogen: anticoagulant effects and binding studies. Chemistry. 2006 ; 12(30) : 7807-15. https://doi.org/10.1002/chem.200600549
  110. Shu C, Chen C, Zhang DP, Guo H, Zhou H, Zong J, Bian Z, Dong X, Dai J, Zhang Y, Tang Q. Gastrodin protects against cardiac hypertrophy and fibrosis. Mol Cell Biochem. 2012 ; 359(1-2) : 9-16. https://doi.org/10.1007/s11010-011-0992-1
  111. Park S, Kim DS, Kang S. Gastrodia elata Blume water extracts improve insulin resistance by decreasing body fat in diet-induced obese rats: vanillin and 4-hydroxybenzaldehyde are the bioactive candidates. Eur J Nutr. 2011 ; 50(2) : 107-18. https://doi.org/10.1007/s00394-010-0120-0
  112. An SM, Park CH, Heo JC, Park JY, Woo SU, Seo JH, Lee MS, Cho KJ, Cho HS, Shin HM, Lee SH. Gastrodia elata Blume protects against stress-induced gastric mucosal lesions in mice. Int J Mol Med. 2007 ; 20(2) : 209-15.
  113. Wang SP, Liu XM, Shang WF, Song J, Yu SR, Sun SM. Effect of Gastrodia on rotation induced motion sickness in mice. Space Med Med Eng. 1999 ; 12(5) : 342-5.
  114. Shu G, Yang T, Wang C, Su H, Xiang M. Gastrodin stimulates anticancer immune response and represses transplanted H22 hepatic ascitic tumor cell growth: Involvement of NF-κB signaling activation in CD4+ T cells. Toxicol App Pharmacol. 2013 ; 269(3) : 270-9. https://doi.org/10.1016/j.taap.2013.02.019
  115. Zheng H, Yang E, Peng H, Li J, Chen S, Zhou J, Fang H, Qiu B, Wang Z. Gastrodin prevents steroid-induced osteonecrosis of the femoral head in rats by anti-apoptosis. Chin Med J. 2014 ; 127(22) : 3926-31.
  116. Wang X, Yan S, Wang A, Li Y, Zhang F. Gastrodin Ameliorates Memory Deficits in 3,3′-Iminodipropionitrile-Induced Rats: Possible Involvement of Dopaminergic System. Neurochem Res. 2014 ; 39(8) : 1458-66. https://doi.org/10.1007/s11064-014-1335-x
  117. Kumar H, Kim IS, More SV, Kim BW, Bahk YY, Choi DK. Gastrodin protects apoptotic dopaminergic neurons in a toxin-induced Parkinson’s disease model. Evid Based Complement Alternat Med. 2013 ; 2013 : 514095-5. https://doi.org/10.1155/2013/514095
  118. Kim HC, Lee BN, Kim YS, Lee SI. Neuroprotective Effect of Gastrodiae Rhizoma on Dopaminergic Neuronal Cell Death in Parkinson's disease. Korea J Herbol. 1999 ; 14(1) : 103-9.
  119. Choi JJ, Oh EH, Lee MK, Chung YB, Hong JT, Oh KW. Gastrodiae Rhizoma Ethanol Extract Enhances Pentobarbital-Induced Sleeping Behaviors and Rapid Eye Movement Sleep via the Activation of GABA A-ergic Transmission in Rodents. Evid Based Complement Alternat Med. 2013 ; 2014 : 426843.
  120. Shin EJ, Kim JM, Nguyen XK, Nguyen TT, Lee SY, Jung JH, Kim MJ, Whang WK, Yamada K, Nabeshima T, Kim HC. Effects of Gastrodia elata Bl on phencyclidine-induced schizophrenia-like psychosis in mice. Curr Neuropharmacol. 2011 ; 9(1) : 247-50. https://doi.org/10.2174/157015911795017263
  121. Shin EJ, Whang WK, Kim S, Bach JH, Kim JM, Nguyen XKT, Nguyen TTL, Jung BD, Yamada K, Nabes T, Kim HC. Parishin C attenuates phencyclidine-induced schizophrenia-like psychosis in mice: involvements of 5-HT1A receptor. J Pharmacol Sci. 2010 ; 113(4) : 404-8. https://doi.org/10.1254/jphs.10040SC
  122. Huang Y, Zheng SL, Xu ZS, Hou Y. Effects of Unprocessed vs. Cooked-processed Gastrodia elata on Cytochrome P450 Enzymes in Rats. Drug Res. 2014 ; 64(8) : 424-8.
  123. Shi Y, Dong JW, Tang LN, Kang RX, Shi JG, Zhang JJ. N 6-(3-methoxyl-4-hydroxybenzyl) adenine riboside induces sedative and hypnotic effects via GAD enzyme activation in mice. Pharmacol Biochem Behav. 2014 ; 126 : 146-51. https://doi.org/10.1016/j.pbb.2014.09.004
  124. Zhang Y, Li M, Kang RX, Shi JG, Liu GT, Zhang JJ. NHBA isolated from Gastrodia elata exerts sedative and hypnotic effects in sodium pentobarbital-treated mice. Pharmacol Biochem Behav. 2012 ; 102(3) : 450-7. https://doi.org/10.1016/j.pbb.2012.06.002
  125. Huang JH, Wang GL. Studies on some pharmacological effects of gastrodia injection and gastrodin. Zhongguo yi xue ke xue yuan xue bao. 1985 ; 7(5) : 399-402.
  126. Zeng X, Zhang Y, Zhang S, Zheng X. A microdialysis study of effects of gastrodin on neurochemical changes in the ischemic/reperfused rat cerebral hippocampus. Biol Pharm Bull. 2007 ; 30(4) : 801-4. https://doi.org/10.1248/bpb.30.801
  127. Yu SJ, Kim JR, Lee CK, Han JE, Lee JH, Kim HS, Hong JW, Kang SG. Gastrodia elata blume and an active component, p-hydroxybenzyl alcohol reduce focal ischemic brain injury through antioxidant related gene expressions. Biol Pharm Bull. 2005 ; 28(6) : 1016-20. https://doi.org/10.1248/bpb.28.1016
  128. Zhao J, Huang R, Li HB. Xiong KR. Effect of electroacupuncture intervention combined with polysaccharide of Gastrodia elata Blume on expression of nestin and stem cell factor around the ischemic locus of frontal lobe cortex in local cerebral ischemia rats. Acu Res. 2015 ; 40(2) : 108-12.
  129. Kim HJ, Lee SR, Moon KD. Ether fraction of methanol extracts of Gastrodia elata, medicinal herb protects against neuronal cell damage after transient global ischemia in gerbils. Phytother Res. 2003 ; 17(8) : 909-12. https://doi.org/10.1002/ptr.1246
  130. Descamps E, Petrault-Laprais M, Maurois P, Pages N, Bac P, Bordet R, Vamecq J. Experimental stroke protection induced by 4-hydroxybenzyl alcohol is cancelled by bacitracin. Neurosci Res. 2009 ; 64(2) : 137-42. https://doi.org/10.1016/j.neures.2009.02.005
  131. Yu SS, Zhao J, Zheng WP, Zhao Y. Neuroprotective effect of 4-hydroxybenzyl alcohol against transient focal cerebral ischemia via anti-apoptosis in rats. Brain Res. 2010 ; 1308 : 167-75. https://doi.org/10.1016/j.brainres.2009.10.037
  132. Kam KY, Yu SJ, Jeong N, Hong JH, Jalin AMA, Lee S, Choi YW, Lee CK, Kang SG. p-Hydroxybenzyl alcohol prevents brain injury and behavioral impairment by activating Nrf2, PDI, and neurotrophic factor genes in a rat model of brain ischemia. Mol Cells. 2011 ; 31(3) : 209-15. https://doi.org/10.1007/s10059-011-0028-4
  133. Kim HJ, Hwang IK, Won MH. Vanillin, 4-hydroxybenzyl aldehyde and 4-hydroxybenzyl alcohol prevent hippocampal CA1 cell death following global ischemia. Brain Res. 2007 ; 1181 : 130-41. https://doi.org/10.1016/j.brainres.2007.08.066
  134. Amemiya S, Kamiya T, Nito C, Inaba T, Kato K, Ueda M, Shimazaki K, Katayama Y. Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats. Eur J Pharmacol. 2005 ; 516(2) : 125-30. https://doi.org/10.1016/j.ejphar.2005.04.036
  135. Song C, Fang S, Lv G, Mei X. Gastrodin promotes the secretion of brain-derived neurotrophic factor in the injured spinal cord. Neural Regen Res. 2013 ; 8(15) : 1383-9.
  136. Youn YS, Lee JS. Effect of Gastrodiae Rhizoma on Apoptosis in Cerebral Infarction Induced by Middle Cerebral Artery Occlusion in Rats. J Orient Rehabilitation Med. 2009 ; 19(3) : 1-13.
  137. Kim KY, Jeong HW, Kim GY. Effects of Gastrodiae Elata Pharmacopuncture at GB20 on Motor Control and Cognitive Function in Mild TBI Rats. Korean J Orient Physiol Pathol. 2009 ; 23(5) : 1080-6.
  138. Kim HC, Ahn DK. Neuroprotective effect of Gastrodiae rhizoma on global ischemia induced by 4-vessel occlusion in rats. Korea J Herbol. 1999 ; 14(1) : 121-9.
  139. Jung JW, Yoon BH, Oh HR, Ahn JH, Kim SY, Park SY, Ryu JH. Anxiolytic-like effects of Gastrodia elata and its phenolic constituents in mice. Biol Pharm Bull. 2006 ; 29(2) : 261-5. https://doi.org/10.1248/bpb.29.261
  140. Chen WC, Tseng TS, Hsiao NW, Lin YL, Wen ZH, Tsai CC, Lee YC, Lin HH, Tsai KC. Discovery of Highly Potent Tyrosinase Inhibitor, T1, with Significant Anti-Melanogenesis Ability by zebrafish in vivo Assay and Computational Molecular Modeling. Sci Rep. 2015 ; 5 : 7995. https://doi.org/10.1038/srep07995
  141. Ahn EK, Jeon HJ, Lim EJ, Jung HJ, Park EH. Anti-inflammatory and anti-angiogenic activities of Gastrodia elata Blume. J Ethnopharmacology. 2007 ; 110(3) : 476-82. https://doi.org/10.1016/j.jep.2006.10.006
  142. Lee JY, Jang YW, Kang HS, Moon H, Sim SS, Kim CJ. Anti-inflammatory action of phenolic compounds fromGastrodia elata root. Arch Pharm Res. 2006 ; 29(10) : 849-58. https://doi.org/10.1007/BF02973905
  143. Huang Q, Shi J, Gao B, Zhang HY, Fan J, Li XJ, Fan ZJ, Yue HH, Zhang JK, Luo ZJ. Gastrodin: An ancient Chinese herbal medicine as a source for anti-osteoporosis agents via reducing reactive oxygen species. Bone. 2015 ; 73 : 132-44. https://doi.org/10.1016/j.bone.2014.12.059
  144. Moon SK, Kim YS, Park SU, Jung WS, Ko CN, Cho KH, Bae HS. Effect of Gastrodia Elata BL water extract on human cerebral blood flow using transcranial Doppler. J Korean Orient Med. 2005 ; 26(1) : 115-22.
  145. Zeng X, Zhang S, Zhang L, Zhang K, Zheng X. A study of the neuroprotective effect of the phenolic glucoside gastrodin during cerebral ischemia in vivo and in vitro. Planta Medica. 2006 ; 72(15) : 1359-65. https://doi.org/10.1055/s-2006-951709
  146. Kim WC, Jeong JK, Kim JS, Kim KO. The Verify of Memory Improvement by Gastrodia Elata Blume. J Orient Neur. 2013 ; 24(1) : 27-44.
  147. Kim WC, Kim JE, Jeong JK, Kim JS, Kim KO. The Verify of Memory Improvement by Gastrodia Elata Blume Depends on the Amount. J Orient Neur. 2014 ; 25(3) : 243-52.
  148. Ju YS. Ungok Herbology. Jeongju : Useok Press. 2013 : 1142.
  149. The Korean Headache Society. Korean Version of The International Classification of Headache Disorders, 3rd Edition. Seoul : Medical Publishing. 2013 : 100, 143.
  150. Oriental Medicine Dictionary Compilation Committee. The Oriental Medicine Dictionary. Seoul : Jungdam Publishing. 2010 : 438, 1413, 1714.
  151. Martini FH, Timmons MJ, Tallitsch RB. Human Anatomy 6th Edition. Benjamin Cummings. 2009 : 455, 485, 495, 496.
  152. Huntington's Outreach Project for Education. The Behavioral Symptoms of Huntington's Disease. Avaliable from : URL : http://web.stanford.edu/group/hopes/cgi-bin/hopes_test/the-behavioral-symptoms-of-huntingtons-disease
  153. Ojemann LM, Nelson WL, Shin DS, Rowe AO, Buchanan RA. Tian ma, an ancient Chinese herb, offers new options for the treatment of epilepsy and other conditions. Epilepsy Behav. 2006 ; 8(2) : 376-83. https://doi.org/10.1016/j.yebeh.2005.12.009
  154. Chen PJ, Sheen LY. Gastrodiae Rhizoma (天麻 tiān má): a review of biological activity and antidepressant mechanisms. J Trad Complement Med. 2011 ; 1(1) : 31-40. https://doi.org/10.1016/S2225-4110(16)30054-2
  155. Huang ZL. Recent developments in pharmacological study and clinical application of Gastrodia elata in China. Zhong Xi Yi Jie He Za Zhi. 1985 ; 5(4) : 251-4.
  156. Tao YH. Recent progress on pharmacological effects of Gastrodia elata. Zhongguo Zhong Yao Za Zhi. 2008 ; 33(1) : 108-10.
  157. Sun XF, Wang W, Wang DQ, Du GY. Research progress of neuroprotective mechanisms of Gastrodia elata and its preparation. Zhongguo Zhong Yao Za Zhi. 2008 ; 29(4) : 292-5.
  158. Marincola FM. Translational medicine: a two-way road. J Transl Med. 2003 ; 1(1) : 1. https://doi.org/10.1186/1479-5876-1-1
  159. Lee WC. The Research about the Classification System Improvement and Cord Development of Korean Classification of Disease on Oriental Medicine. Korean J Orient Int Med. 2010 ; 31(1) : 1-10.
  160. State Administration of Traditional chinese medicine of the People's Republic of China. Chinese Herbal Medicine. Shanghai : Shanghai Scientific and Technical Publishers. 1999 : 8, 717.
  161. Kim CM, Shin MG, Ahn DG, et al. A Complete Translation Encyclopedia of Chinese Herbal Medicine. Seoul : Jungdam. 1999 : 4105-7.
  162. Burns A, Iliffe S. Dementia. BMJ 2009;338 : b75. Avaliable from : http://dx.doi.org/10.1136/bmj.b75 https://doi.org/10.1136/bmj.b75
  163. National Health Insurance Corporation. Inpatient Benefits by Frequency of Disease In 2013. Seoul : Statistics Korea. Avaliable from : http://kosis.kr/statHtml/statHtml.do?orgId= 350&tblId=DT_35001_A076111&conn_path=I2
  164. Kim HJ, Choi GY, Kim C, Lee GS, Kim JH, Lee SH, Hwang SY, Ju YS. Survey on Revision and Complements for the Current Curriculum of Herbology. J Korean Oriental Med. 2009 ; 30(4) : 118-28.