DOI QR코드

DOI QR Code

The Literature Study of Research Trend of Alismatis Rhizoma and Relationship Between the Herbology and KCD

택사(澤瀉)의 국내·외 연구동향과 『본초학』, 한국표준질병사인분류의 상관관계에 대한 연구

Jang, Il-Woong;Jeong, Jong-Kil;Kim, Hyun-Seok;Lee, Soong-In
장일웅;정종길;김현석;이숭인

  • Received : 2016.02.20
  • Accepted : 2016.03.17
  • Published : 2016.03.30

Abstract

Objectives : This study was aimed to analyze the correlation between the Herbology and contemporary research results, KCD and terms of Alismatis Rhizoma. The study will present information that can be used to find the direction of further researches and be applied to the education of Herbology.Methods : Papers were searched in Riss4U and PubMed, and categorized. Medicine or pharmacy articles about Alismatis Rhizoma were matched with the Herbology treatment and KCD. KCD-codes and terms were arranged by the Herbology treatment. The Degree of Herbology research (HDR) was calculated by numbers of papers, study method, citation rates.Results : There were 392 articles about Alismatis Rhizoma. Among these there were 141 medicine and pharmacy articles about Alismatis Rhizoma, and 51 articles were matched to the Herbology treatment. Studies about Phlegm-Fluid Retention and Dizziness, Edema and Distention and Fullness was more active than others. Analysis of other articles showed that studies about anti-cancer, anti-biotic effect, anti-diabetes mellitus, anti-oxidant effect, anti-inflammation, hepatoprotective effect were active, too. In HDR, Phlegm-Fluid Retention and Dizziness was scored by 181, Edema- Distention and Fullness by 173, Hyperlipidemia by 83, Dysuria 64, Heat strangury pain by 18, Diarrhea and decreased urine volum by 0.Conclusions : 141 articles about Alismatis Rhizoma were analyzed and 51 articles were matched to the Herbology treatment. Studies about Phlegm-Fluid Retention and Dizziness, Edema and Distention and Fullness were more active than others. And studies about anti-cancer, anti-biotic effect, anti-oxidant effect, anti-inflammation, Osteoporosis should be more studied and be more discussed among Herbology researchers.

Keywords

Alismatis Rhizoma;Alisma plantago-aquatica var. orientale;Alisma orientalis;Herbal Medicine;Herbology

References

  1. Herbology Editorial Committee of Korean Medicine schools. Boncho-hak. Seoul : Young-Lim Press. 2004 : 348-9.
  2. The Ministry of Food and Drug Safety. Herbal Medicine Database. Avaliable from : URL : http://www.mfds.go.kr/files/upload/herbmed/photo_data/KP1411.pdf
  3. Pharmacopoeia Commission of the People's Republic of China, Pharmacopoeia of the People's Republic of China, 2010. Beijing : China Medical Science and Technology Press. 2010 : 212.
  4. Yoo JH. Overview for Studies on Alismatis Rhizoma in the Korean Literatures;Yiksan:Wonkwang University Graduate School. 2012.
  5. Kim HS, Jeong JK, Lee SI. The Literature Study of Research Trend of Menthae Herba and Relationship Between the Herbology and KCD-code. Kor J Herbol. 2015 ; 30(5) : 29-43. https://doi.org/10.6116/kjh.2015.30.5.29.
  6. Chou CC, Pan SL, Teng CM, Guh JH. Pharmacological evaluation of several major ingredients of Chinese herbal medicines in human hepatoma Hep3B cells. Eur J Pharm Sci. 2003 ; 19(5) : 403-12. https://doi.org/10.1016/S0928-0987(03)00144-1
  7. Huang YT, Huang DM, Chueh SC, Teng CM, Guh JH. Alisol B acetate, a triterpene from Alismatis rhizoma, induces Bax nuclear translocation and apoptosis in human hormone-resistant prostate cancer PC-3 cells. Cancer Lett. 2006 ; 231(2) :270-8. https://doi.org/10.1016/j.canlet.2005.02.011
  8. Xu W, Li T, Qiu JF, Wu SS, Huang MQ, Lin LG, Zhang QW, Chen XP, Lu JJ. Anti-proliferative activities of terpenoids isolated from Alisma orientalis and their structure-activity relationships. Anticancer Agents Med Chem. 2015 ; 15(2) : 228-35. https://doi.org/10.2174/1871520614666140601213514
  9. Law BY, Wang M, Ma DL, Al-Mousa F, Michelangeli F, Cheng SH, Ng MH, To KF, Mok AY, Ko RY, Lam SK, Chen F, Che CM, Chiu P, Ko BC. Alisol B, a novel inhibitor of the sarcoplasmic/endoplasmic reticulum Ca(2+) ATPase pump, induces autophagy, endoplasmic reticulum stress, and apoptosis. Mol Cancer Ther. 2010 ; 9(3) : 718-30. https://doi.org/10.1158/1535-7163.MCT-09-0700
  10. Lee S, Kho Y, Min B, Kim J, Na M, Kang S, Maeng H, Bae K. Cytotoxic triterpenoides from Alismatis Rhizoma. Arch Pharm Res. 2001 ; 24(6) : 524-6. https://doi.org/10.1007/BF02975158
  11. Chen HW, Hsu MJ, Chien CT, Huang HC. Effect of alisol B acetate, a plant triterpene, on apoptosis in vascular smooth muscle cells and lymphocytes. Eur J Pharmacol. 2001 ; 419(2-3) : 127-38. https://doi.org/10.1016/S0014-2999(01)00983-9
  12. Lee S, Min B, Bae K. Chemical modification of alisol B 23-acetate and their cytotoxic activity. Arch Pharm Res. 2002 ; 25(5) : 608-12. https://doi.org/10.1007/BF02976929
  13. Nie XJ, Zhao XP, Wang Y. Development of fluorescence imaging based assay for screening compounds with anti-migration activity. Yao Xue Xue Bao. 2011 ; 46(7) : 793-7.
  14. Lin HR. Triterpenes from Alisma orientalis act as androgen receptor agonists, progesterone receptor antagonists, and glucocorticoid receptor antagonists. Bioorg Med Chem Lett. 2014 ; 24(15) : 3626-32. https://doi.org/10.1016/j.bmcl.2014.05.039
  15. Bae KH, Jung HJ, Park JY, Na MK, Lee JP. Cytotoxic and Antitumor constituens from Korean medicinal plants. Int Symp East-West Med. 1999 ; 1999(1) : 153-61.
  16. Jin HG, Jin Q, Ryun Kim A, Choi H, Lee JH, Kim YS, Lee DG, Woo ER. A new triterpenoid from Alisma orientale and their antibacterial effect. Arch Pharm Res. 2012 ; 35(11) : 1919-26. https://doi.org/10.1007/s12272-012-1108-5
  17. Chen J, Liu R, Han Q, Xia C, Luo J, Han J, Mei Y, Jian W, Ou S. A preliminary study of two Chinese herbs protective tablets on some Chinese traditional medicines. Zhong Yao Cai. 1999 ; 22(11) : 566-9.
  18. Adams M, Gschwind S, Zimmermann S, Kaiser M, Hamburger M. Renaissance remedies:Antiplasmodial protostane triterpenoids from Alisma plantago-aquatica L. (Alismataceae). J Ethnopharmacol. 2011 ; 135(1) : 43-7. https://doi.org/10.1016/j.jep.2011.02.026
  19. Do JA. Antimicrobial and Antifungal Studies on Alismae Rhizoma. Nat Prod Sci. 1996 ; 27(4) : 378-82.
  20. Seo GI, Cho YS, Park JR, Lee ST, Park CG. Antimicrobial and Antioxidative Effects of Alismatis Rhizoma Extract. Nat Prod Sci. 2000 ; 10(5) : 524-8.
  21. Cha JD, Hwang SM, Ko ES, Choi KM. Antibacterial Activity of the Ethanol Extract of Alismatis rhizoma against Oral Pathogens. Korea J Biotechnol Bioengin. 2015 ; 2015(4) : 520.
  22. Rau O, Wurglics M, Dingermann T, Abdel-Tawab M, Schubert-Zsilavecz M. Screening of herbal extracts for activation of the human peroxisome proliferator-activated receptor. Pharmazie. 2006 ; 61(11) : 952-6.
  23. Lau CH, Chan CM, Chan YW, Lau KM, Lau TW, Lam FC, Che CT, Leung PC, Fung KP, Ho YY, Lau CB. In vitro antidiabetic activities of five medicinal herbs used in Chinese medicinal formulae. Phytother Res. 2008 ; 22(10) : 1384-8. https://doi.org/10.1002/ptr.2513
  24. Lau TW, Chan YW, Lau CP, Chan CM, Lau CB, Fung KP, Leung PC, Ho YY. Investigation of the effects of Chinese medicine on fibroblast viabilit y:implications in wound healing. Phytother Res. 2007 ; 21(10) : 938-47. https://doi.org/10.1002/ptr.2191
  25. Lin HR. Triterpenes from Alisma orientalis act as farnesoid X receptor agonists. Bioorg Med Chem Lett. 2012 ; 22(14) : 4787-92. https://doi.org/10.1016/j.bmcl.2012.05.057
  26. Zhao ZY, Zhang Q, Li YF, Dong LL, Liu SL. Optimization of ultrasound extraction of Alisma orientalis polysaccharides by response surface methodology and their antioxidant activities. Carbohydr Polym. 2015 ; 119 : 101-9. https://doi.org/10.1016/j.carbpol.2014.11.052
  27. Choi GY, Han GJ, Ha SC. α-Glucosidase Inhibitory Substances Exploration Isolated from the Herb Extract. Korean J Food Pre. 2011 ; 18(4) : 620-5. https://doi.org/10.11002/kjfp.2011.18.4.620
  28. Choi GY. Searching Medicinal Herbs with Hypoglycemic Effect and the Quality Characteristics of Functional White pan bread. Uiduk university Graduate School. 2012.
  29. Kim SE, Rhyu DY, Yokozawa T, Park JC. Antioxidant Effect of Alisma plantago-aquatica var. orientale and Its Main Component. Korean J Pharm. 2007 ; 38(4) : 372-5.
  30. Yang YY, Lee MJ, Jung HJ. Screening of Antioxidative, Anti-atherosclerotic Effect of Alisma Rhizome Extracts. Korean J Orient Int Med. 2008 ; 29(4) : 988-99.
  31. Lee SN, Kim MG, Kim MH, Kim HJ, Jo HJ, Kim EH, Leem KH. Effects of Alismatis Rhizoma Pharmacopuncture Extracts on the Elastase Activity and DPPH and NO Scavenging Activities. Kor J Acupuncture. 2011 ; 28(1) : 15-22.
  32. Kim SE. Isolation of Alisol B 23-acetate and Anti-oxidant Activities of Alisma plantago-aquatica var. orientale Rhizome, and Quantitative Analysis of Alismatis Rhizoma in Korea and China. Suncheon university Graduate School. 2004.
  33. Lee YY. The Effect of Alismatis Rhizoma extracts on NAD(P)H oxidase-induced oxidant stress in blood vessel smooth muscle cell. Dongguk university Graduate School. 2010.
  34. Matsuda H, Kageura T, Toguchida I, Murakami T, Kishi A, Yoshikawa M. Effects of sesquiterpenes and triterpenes from the rhizome of Alisma orientale on nitric oxide production in lipopolysaccharideactivated macrophages:absolute stereostructures of alismaketones-B 23-acetate and-C 23-acetate. Bioorg Med Chem Lett. 1999 ; 9(21) : 3081-6. https://doi.org/10.1016/S0960-894X(99)00536-3
  35. An SM, Kim HG, Choi EJ, Hwang HH, Lee ES, Beak JH, Bhu YC, Ko JS. Screening for Anti-inflammatory Activities in Extracts from Korean Herb Medicines. J Soc Cosmetic Sci Korea. 2014 ; 40(1) : 95-108. https://doi.org/10.15230/SCSK.2014.40.1.95
  36. Han CW, Kwun MJ, Kim KH, Choi JY, Oh SR, Ahn KS, Joo M. Ethanol extract of Alismatis Rhizoma reduces acute lung inflammation by suppressing NF-κB and activating Nrf2. J Ethnopharmacol. 2013 ; 146(1) : 402-10. https://doi.org/10.1016/j.jep.2013.01.010
  37. Kim NY, Kang TH, Pae HO, Choi BM, Chung HT, Myung SW, Kim YC. In vitro inducible nitric oxide synthesis inhibitors from Alismatis Rhizoma. Biol Pharm Bull. 1999 ; 22(10) : 1147-9. https://doi.org/10.1248/bpb.22.1147
  38. Joo MJ. Immunoregulatory effect of ethanol extract of Alisma orientale Juzepzuk in RAW264.7 cells. Wonkwang university Graduate School. 2015.
  39. Han CW, Kang ES, Ham SA, Woo HJ, Lee JH, Seo HG. Antioxidative effects of Alisma orientale extract in palmitate-induced cellular injury. Pharm Biol. 2012 ; 50(10) : 1281-8. https://doi.org/10.3109/13880209.2012.673629
  40. Han CW. Aqueous extract of Alisma oriental Attenuates palmitate-induced cellular injury by inhibiting production of reactive oxygen species in HepG2 cells. Kyunghee university Graduate School. 2010.
  41. Chang IM, Kim YS, Yun HS, Kim SO. Liver-protective activities of alisol compounds against carbon tetrachloride intoxication. Saengyak Hakhoe Chi. 1982 ; 13(3) : 112-5.
  42. Kim EY, Lee JH. The Effect of Alisma orientale Extract on Free Fatty Acid-induced Lipoapoptosis in HepG2 Cells. Korean J Orient Int Med. 2014 ; 35(2) : 184-94.
  43. Han CW, Joo MS, Lee JH. Comparison of the Therapeutic Efficacy of Rhizoma Alismatis, Fructus Crataegi, Fructus Lycii, Radix Curcumae, Radix Salviae Miltiorrhizae, Herba Artemisiae Scopariae on the Experimental Cellular Model of Nonalcoholic Fatty Liver Disease. Korean J Orient Int Med. 2012 ; 33(4) : 533-42.
  44. Lee HK, Bae KH, Min BS, Na MK, An RB, Kim JH, Lee SM. Prostane-type Triterpenes from Alismatis Rhizoma and Their Anti-complement Activity. J Pharm Soc Korea. 2002 ; 2002(2) : 373-4.
  45. Lee SM, Kim JH, Zhang Y, An RB, Min BS, Joung H, Lee HK. Anti-complementary activity of protostane-type triterpenes from Alismatis rhizoma. Arch Pharm Res. 2003 ; 26(6) : 463-5. https://doi.org/10.1007/BF02976863
  46. Tomoda M, Gonda R, Shimizu N, Ohara N. Characterization of an acidic polysaccharide having immunological activities from the tuber of Alisma orientale. Biol Pharm Bull. 1994 ; 17(5) : 572-6. https://doi.org/10.1248/bpb.17.572
  47. Shimizu N, Ohtsu S, Tomoda M, Gonda R, Ohara N. A glucan with immunological activities from the tuber of Alisma orientale. Biol Pharm Bull. 1994 ; 17(12) : 1666-8. https://doi.org/10.1248/bpb.17.1666
  48. Matsuda H, Kobayashi G, Yamahara J, Fujimura H, Kurahashi K, Fujiwara M. Effects of alismol isolated from Alismatis Rhizoma on calcium-induced contraction in the rabbit thoracic aorta. Life Sci. 1987 ; 41(15) : 1845-52. https://doi.org/10.1016/0024-3205(87)90704-1
  49. Makino B, Kobayashi M, Kimura K, Ishimatsu M, Sakakibara I, Higuchi M, Kubo M, Sasaki H, Okada M. Local variation in the content of angiotensin II and arginine vasopressin receptor antagonistic terpenoids in the rhizomes of Alisma orientale. Planta Med. 2002 ; 68(3) : 226-31. https://doi.org/10.1055/s-2002-23129
  50. Matsuda H, Yamahara J, Kobayashi G, Fujimura H, Kurahashi K, Fujiwara M. Effect of alismol on adrenergic mechanism in isolated rabbit ear artery. Jpn J Pharmacol. 1988 ; 46(4) : 331-5. https://doi.org/10.1254/jjp.46.331
  51. Lee SE, Bang JK, Song J, Seong NS, Park HW, Chung HG, An TJ. Inhibitory activity on angiotensin converting enzyme (ACE) of Korean medicinal herbs. Korean J Med Crop Sci. 2004 ; 12(1) : 73-8.
  52. Wang C, Zhang JX, Shen XL, Wan CK, Tse AK, Fong WF. Reversal of P-glycoprotein-mediated multidrug resistance by Alisol B 23-acetate. Biochem Pharmacol. 2004 ; 68(5) : 843-55. https://doi.org/10.1016/j.bcp.2004.05.021
  53. Park YJ, Kim MS, Kim HR, Kim JM, Hwang JK, Yang SH, Kim HJ, Lee DS, Oh H, Kim YC, Ryu DG, Lee YR, Kwon KB. Ethanol Extract of Alismatis rhizome Inhibits Adipocyte Differentiation of OP9 Cells. Evid Based Complement Alternat Med. 2014 ; 2014 : 415097.
  54. Fong WF, Wang C, Zhu GY, Leung CH, Yang MS, Cheung HY. Reversal of multidrug resistance in cancer cells by Rhizoma Alismatis extract. Phytomedicine. 2007 ; 14(2-3) : 160-5. https://doi.org/10.1016/j.phymed.2006.03.004
  55. Hyuga S, Shiraishi M, Hori A, Hyuga M, Hanawa T. Effects of Kampo medicines on MDR-1-mediated multidrug resistance in human hepatocellular carcinoma HuH-7/PTX cells. Biol Pharm Bull. 2012 ; 35(10) : 1729-39. https://doi.org/10.1248/bpb.b12-00371
  56. Guo AJ, Choi RC, Cheung AW, Li J, Chen IX, Dong TT, Tsim KW, Lau BW. Stimulation of Apolipoprotein A-IV expression in Caco-2/TC7 enterocytes and reduction of triglyceride formation in 3T3-L1 adipocytes by potential anti-obesity Chinese herbal medicines. Chin Med. 2009 ; 4 : 5. https://doi.org/10.1186/1749-8546-4-5
  57. Eun JS, Hong JS, So JN. Effects of the Extracts from Hoelen alba, Alismatis Rhizoma and Atractylodes Rhizoma on Proliferation and Differentiation of 3T3-L1 Cells. J Korean Soc Pharm. 1993 ; 24(2) : 131-9.
  58. Yoshikawa M, Fukuda Y, Hatakeyama S, Tanaka N, Matsuda H, Yamahara J, Murakami N. Sulfoorientalols a, b, c, and d, four new biologically active sesquiterpenes from Alismatis rhizoma. Chem Pharm Bull. 1993 ; 41(6) : 1194-6. https://doi.org/10.1248/cpb.41.1194
  59. Yoshikawa M, Yamaguchi S, Matsuda H, Tanaka N, Yamahara J, Murakami N. Crude drugs from aquatic plants. V. On the constituents of alismatis rhizoma. (3). Stereostructures of water-soluble bioactive sesquiterpenes, sulfoorientalols a, b, c, and d, from Chinese alismatis rhizoma. Chem Pharm Bull. 1994 ; 42(12) : 2430-5. https://doi.org/10.1248/cpb.42.2430
  60. Kim JY. Study of Alismatis Rhizoma induced ligand-gated ion channel regulation. Kyunghee university Graduate School. 2010.
  61. Jiang ZY, Zhang XM, Zhou J, Zhang FX, Chen JJ, Lü Y, Wu L, Zheng QT. Two new sesquiterpenes from Alisma orientalis. Chem Pharm Bull. 2007 ; 55(6) : 905-7. https://doi.org/10.1248/cpb.55.905
  62. Lee JH, Lee YJ, Kang SW, Kim Y, Shin M, Hong M, Seo EK, Kim SH, Nah SY, Bae H. Effects of protostane-type triterpenoids on the 5-HT3A receptor-mediated ion current in Xenopus oocytes. Brain Res. 2010 ; 1331 : 20-7. https://doi.org/10.1016/j.brainres.2010.03.041
  63. Kang SW. Study of protostane-type triterpenoids from Alismatis rhizoma on regulation of human serotonin type 3A receptor. Kyunghee university Graduate School. 2010.
  64. Jiang ZY, Zhang XM, Zhang FX, Liu N, Zhao F, Zhou J, Chen JJ. A new triterpene and anti-hepatitis B virus active compounds from Alisma orientalis. Planta Med. 2006 ; 72(10) : 951-4. https://doi.org/10.1055/s-2006-947178
  65. Yoo G. The regulatory effect of Alisma Rhizomes and triterpenoids on α3β4 nicotinic acetylcholine receptor channel activity. Kyunghee university Graduate School. 2011.
  66. Xue X, Chen T, Wei W, Zhou X, Lin Z, Chen L. Effects of Alisma Decoction on lipid metabolism and inflammatory response are mediated through the activation of the LXRα pathway in macrophage-derived foam cells. Int J Mol Med. 2014 ; 33(4) : 971-7. https://doi.org/10.3892/ijmm.2014.1646
  67. Mai ZP, Zhou K, Ge GB, Wang C, Huo XK, Dong PP, Deng S, Zhang BJ, Zhang HL, Huang SS, Ma XC. Protostane Triterpenoids from the Rhizome of Alisma orientale Exhibit Inhibitory Effects on Human Carboxylesterase 2. J Nat Prod. 2015 ; 78(10) : 2372-80. https://doi.org/10.1021/acs.jnatprod.5b00321
  68. Zhang C, Zhou A, Zhang M. Chemical constituents of Alisma orientalis and their immunosuppressive function. Zhongguo Zhong Yao Za Zhi. 2009 ; 34(8) : 994-8.
  69. Park JO, Sunwoo KO, Kim KS. Purification and characterization of hemagglutinating protein from rhizome of Alisma orientale. Korean J Food Nut. 1995 ; 24(4) : 587-93.
  70. Rhew KY. Antioxidative Effects of Dichloromethane Extract of Alisma orientale on Non-alcoholic Fatty Liver Disease Induced by Methionine and Choline-deficient (MCD) Diet. Kyunghee University Graduate School. 2012.
  71. Wang J, Fu X, Bai H. Study on extracting process of ethanol extract with hypouricemic effect from rhizoma alismatis. Zhongguo Zhong Yao Za Zhi. 2010;35(14):1809-11.
  72. Han JH, Song HJ, Kang SY, Kim GS, Oh KS. Effects of Biological Active Plants on the Isolated Rat and Guinea Pig Trachea Smooth muscle. Korean J Orient Int Med. 1996 ; 17(1) : 204-9.
  73. Zhao X, Lu L, Zhang Y, Zhang B. Study on discriminating nephrotoxic components in Zexie. Zhongguo Zhong Yao Za Zhi. 2011 ; 36(6) : 758-61.
  74. Jang MK, Han YR, Nam JS, Han CW, Kim BJ, Jeong HS, Ha KT, Jung MH. Protective Effects of Alisma orientale Extract against Hepatic Steatosis via Inhibition of Endoplasmic Reticulum Stress. Int J Mol Sci. 2015 ; 16(11) : 26151-65. https://doi.org/10.3390/ijms161125944
  75. Kwon HJ, Kim YY, Choung SY. Amelioration effects of traditional Chinese medicine on alcohol-induced fatty liver. World J Gastroenterol. 2005 ; 11(35) : 5512-6. https://doi.org/10.3748/wjg.v11.i35.5512
  76. Seo MJ, Ha H, Yoon SH. Effects of Alismatis Rhizoma Extracts on Lipid Components in Experimental Liver Injury. J Korean Soc Env Health Toxicol. 1995 ; 10(2) : 15-20.
  77. Liu ZL, Xie LZ, Zhu J, Li GQ, Grant SJ, Liu JP. Herbal medicines for fatty liver diseases. Cochrane Database Syst Rev. 2013 ; 8 : CD009059.
  78. Hong X, Tang H, Wu L, Li L. Protective effects of the Alisma orientalis extract on the experimental nonalcoholic fatty liver disease. J Pharm Pharmacol. 2006 ; 58(10) : 1391-8. https://doi.org/10.1211/jpp.57.10.0013
  79. Meng Q, Chen X, Wang C, Liu Q, Sun H, Sun P, Huo X, Liu Z, Liu K. Protective effects of alisol B 23-acetate from edible botanical Rhizoma alismatis against carbon tetrachloride-induced hepatotoxicity in mice. Food Funct. 2015 ; 6(4) : 1241-50. https://doi.org/10.1039/C5FO00082C
  80. Kwon HJ, Hyun SH, Choung SY. Traditional Chinese Medicine improves dysfunction of peroxisome proliferator-activated receptor alpha and microsomal triglyceride transfer protein on abnormalities in lipid metabolism in ethanol-fed rats. Biofactors. 2005 ; 23(3) : 163-76. https://doi.org/10.1002/biof.5520230305
  81. Yoon SH, Seo MJ, Ha H. Effects of Alismae Rhizoma on benzo(a)pyrene-induced hepatotoxicity in rats. Res Bull. 1996 ; 52(2) : 141-7.
  82. Hur JM, Choi JW, Park JC. Effects of methanol extract of Alisma orientale rhizome and its major component, alisol B 23-acetate, on hepatic drug metabolizing enzymes in rats treated with bromobenzene. Arch Pharm Res. 2007 ; 30(12) : 1543-9. https://doi.org/10.1007/BF02977323
  83. Jeong CS, Hyun JE. Screening of hepatoprotective activity of medicinal plant extracts on carbon tetrachloride-induced hepatotoxicity in rats. Nat Prod Sci. 2003 ; 9(2) : 87-90.
  84. Yoon SH, Seo MJ, Jang YH, Kwon OJ. The Effect of Alismatis Extract on Benzo(a)pyrene Induced Hepatotoxicity = Studies on the Hepatotropic Effect of Natural Resources. J Korean Env Hygienic Sci. 1992 ; 2(1) : 109-14.
  85. Yuen MF, Tam S, Fung J, Wong DH, Wong BY, Lai CL. Traditional Chinese medicine causing hepatotoxicity in patients with chronic hepatitis B infection: a 1‐year prospective study. Aliment Pharmacol Ther. 2006 ; 24(8) : 1179-86. https://doi.org/10.1111/j.1365-2036.2006.03111.x
  86. Han JG, Kim YS, Kim BS, Yim YK. The Effect of Alismatis Rhizoma Herbal-acupuncture at KI10 on LPS-induced Nephritis in Rats. J Korean Acu Mox Med Soc. 2014 ; 31(1) : 51-60.
  87. Nam JW, Lee SH, Kang MS, Choi YK, Jun CY, Park CH, Kim DW. Effects of Different Lengths of Treatment with Rhizoma Alismatis on Diabetic Mellitus of Streptozotocin-Induced Hyperglycemic Rats. Korean J Orient Int Med. 2006 ; 27(4) : 791-7.
  88. Ding CY, Tan QY, Shi NC. Alisma versus Gliclazide in the Treatment of Primary Diabetes in Goto-Kakizaki Rats. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2015 ; 37(4) : 451-5.
  89. Kim MH. Diabetes Mellitus and Antidiabetic Foods. J Duk-Sung Women's Univ Plant Res Res. 2010 ; 9 : 3-20.
  90. Lee KH. Effects of Different dosage of Rhinzoma Alismatis on diabetes Mellitus of the streptozotocin-Induced Rats. Gachon university Graduate School. 2003.
  91. Lim SJ, Won SB. Effects of Korean wild vegetables on blood glucose levels and energy metabolites in streptozotocin-induced diabetic rats. Korean J Soc Food Sci. 1997 ; 13 : 639-47.
  92. Kim DJ. Effect of Natural Plants Extract Supplementation on Carbohydrate Metabolism-Related Enzymes Activities in Cellular Fractions of GK (Goto-Kakizaki) Rats. Gachon university Graduate School. 2008.
  93. Hsu PC, Tsai YT, Lai JN, Wu CT, Lin SK, Huang CY. Integrating traditional Chinese medicine healthcare into diabetes care by reducing the risk of developing kidney failure among type 2 diabetic patients:a population-based case control study. J Ethnopharmacol. 2014 ; 156 : 358-64. https://doi.org/10.1016/j.jep.2014.08.029
  94. Li Q, Qu H. Study on the hypoglycemic activities and metabolism of alcohol extract of Alismatis Rhizoma. Fitoterapia. 2012 ; 83(6) : 1046-53. https://doi.org/10.1016/j.fitote.2012.05.009
  95. Hattori T, Nishimura H, Makino B, Shindo S, Kawamura H. Sairei-to inhibits the production of endothelin-1 by nephritic glomeruli(2):alisols, possible candidates as active compounds. Nihon Jinzo Gakkai Shi. 1998 ; 40(2) : 33-41.
  96. Lee SB, Kim ON, Cho BH, Cho GC. Hypotensive Action of Coptis rhizoma, Alismatis rhizoma and Acanthopanis cortex radicis in Rat. New Med J. 1978 ; 21(4) : 89-97.
  97. Yamahara J, Matsuda H, Murakami H, Fujimura H. The active principle of alismatis rhizoma which inhibits contractile responses in aorta. Chem Pharm Bull. 1986 ; 34(10) : 4422-4. https://doi.org/10.1248/cpb.34.4422
  98. Kim YS, Yoon HS, Jeong SH. Effect of Alisols Isolated from Alisma orientale Jazep·Against Several Agonists in Isolated Rat Ileum. J Korean Soc Pharm. 1981 ; 12(4) : 200-2.
  99. Lee EH. Study on Depressor Action of Alismae Water Extract. Chosun university Graduate School. 1974.
  100. Chu Y, Jiang H, Ju J, Li Y, Gong L, Wang X, Yang W, Deng Y. A metabolomic study using HPLC-TOF/MS coupled with ingenuity pathway analysis:Intervention effects of Rhizoma Alismatis on spontaneous hypertensive rats. J Pharm Biomed Anal. 2016 ; 117 : 446-52. https://doi.org/10.1016/j.jpba.2015.09.026
  101. Hattori T, Fujitsuka N, Kurogi A, Shindo S. Sairei-to may inhibit the synthesis of endothelin-1 in nephritic glomeruli. Nihon Jinzo Gakkai Shi. 1997 ; 39(2) : 121-8.
  102. Lin WS. Diagnostic value of Rhizoma alismatis mixture in Meniere's disease. Zhong xi yi jie he za zhi. 1991 ; 11(12) : 717-8.
  103. Cao ZG, Liu JH, Radman AM, Wu JZ, Ying CP, Zhou SW. An experimental study of effect of different extracts of Alisma orientalis on urinary calcium oxalate stones formation in rats. Zhongguo Zhong Yao Za Zhi. 2003 ; 28(11) : 1072-5.
  104. Cao ZG, Liu JH, Zhou SW, Wu W, Yin CP, Wu JZ. The effects of the active constituents of Alisma orientalis on renal stone formation and bikunin expression in rat urolithiasis model. Zhonghua Yi Xue Za Zhi. 2004 ; 84(15) : 1276-9.
  105. Choi JS. Experimental Study on the Effects of Alismatis Lhizoma on Hyperlipidemia. Graduate school of Kyung-san University. 1998.
  106. Kim HJ. Reserach of treating Heperlipidemia and atherosclerosis by Replenish qi, Tonify the Kidney, Fortify the Spleen, Dispel Phlegm Medicine. Hebei Medical University Graduate School. 1999.
  107. Dan H, Wu J, Peng M, Hu X, Song C, Zhou Z, Yu S, Fang N. Hypolipidemic effects of Alismatis rhizome on lipid profile in mice fed high-fat diet. Saudi Med J. 2011 ; 32(7) : 701-7.
  108. Li S, Jin S, Song C, Chen C, Zhang Y, Xiang Y, Xu Y, Feng Y, Wan Q, Jiang H. The metabolic change of serum lysophosphatidylcholines involved in the lipid lowering effect of triterpenes from Alismatis rhizoma on high-fat diet induced hyperlipidemia mice. J Ethnopharmacol. 2016 ; 177 : 10-8. https://doi.org/10.1016/j.jep.2015.11.017
  109. Song C, Huang X, Lu K, Peng M, Yu S, Fang N. The rationality of the hypolipidemic effect of alismatis rhizoma decoction, a classical chinese medicine formula in high-fat diet-induced hyperlipidemic mice. Iran J Pharm Res. 2014 ; 13(2) : 641-9.
  110. Yin XJ, He QY. Compatibility regularity of compound traditional Chinese medicine patents based on association principle and entropy method. Zhongguo Zhong Yao Za Zhi. 2015 ; 40(3) : 550-5.
  111. Hong JS. Effect of crude drugs on proliferation and differentiation of 3T3-L1 cells. Woosuk university Graduate School. 1993.
  112. Lee JC, Lee E, Lee YC. Effects of Rhizoma Alismatis on Lipid Composition and TBARS Concentration in Rat Fed High Fat Diet. Kor J Herbol. 2008 ; 23(3) : 113-7.
  113. Jeong HS. Efficacy of Alismatis Orientale Rhizoma on Obesity induced by High Fat Diet. Kor J Herbol. 2013 ; 28(3) : 95-106. https://doi.org/10.6116/kjh.2013.28.3.95
  114. Joo JS, Chae WS, Shin MS, Na CS. A literatural study on acupoints and herbs for treating obesity by herbal acupuncture. Kor J Acu. 2004 ; 20(3) : 147-62.
  115. Jin GS. An Analysis of the Tendency to Research for Obesity. Daejeon university Graduate School. 2004.
  116. Yoon WH, Lee KH. Screening of Anti-atopic Herbs Having Phosphodiesterase 4 and 7 Inhibition. Korean J Pharm. 2014 ; 45(3) : 268-74.
  117. Lee JW, Kobayashi Y, Nakamichi Y, Udagawa N, Takahashi N, Im NK, Woo JT. Alisol-B, a novel phyto-steroid, suppresses the RANKL-induced osteoclast formation and prevents bone loss in mice. Biochem Pharmacol. 2010 ; 80(3) : 352-61. https://doi.org/10.1016/j.bcp.2010.04.014
  118. Kim KJ. Osteoclast Differentiation Inhibitors Screening for New Drug Development of Bone Disease and Studying Their Action Mechanisms. Suncheon university Graduate School. 2015.
  119. Gao Z, Lu Y, Halmurat Upur, Jing J, Xu D. Study of osteoporosis treatment principles used historically by ancient physicians in Chinese Medicine. Chin J Integr Med. 2013 ; 19(11) : 862-8. https://doi.org/10.1007/s11655-013-1328-z
  120. Lee JH, Kwon OS, Jin HG, Woo ER, Kim YS, Kim HP. The rhizomes of Alisma orientale and alisol derivatives inhibit allergic response and experimental atopic dermatitis. Biol Pharm Bull. 2012 ; 35(9) : 1581-7. https://doi.org/10.1248/bpb.b110689
  121. Li J, Lu Z, Wu N, Zhou J, Shi Y. A scanning electron microscopy and computer image processing morphometric study of the pharmacological regulation of patency of the peritoneal stomata. Ann Anat. 1996 ; 178(5) : 443-7. https://doi.org/10.1016/S0940-9602(96)80137-3
  122. Ding SP, Li JC, Xu J, Mao LG. Study on the mechanism of regulation on the peritoneal lymphatic stomata with Chinese herbal medicine. World J Gastroenterol. 2002 ; 8(1) : 188-92. https://doi.org/10.3748/wjg.v8.i1.188
  123. He XY. Effects of Alisma plantago L on hyperlipemia, atherosclerosis and fatty liver. Zhong Xi Yi Jie He Za Zhi. 1981 ; 1(2) : 114-7.
  124. Lee MJ, Chang GT, Han YJ. The Study for Precocious Puberty in Recent Journals of Traditional Chinese Medicine. J Korean Orient Ped. 2008 ; 22(1) : 163-87.
  125. Ko ST. Crude Drugs Acting on the Renal Function. On Atractylis, Hoelen, Alisma and Polyporus. J Pharm Soc Korea. 1975 ; 19(2) : 65-78.
  126. Lee SM. Analysis of Alismatis Rhizoma Extracts and derivatice's Anti cancer effect. Chungnam national university Graduate School. 2000.
  127. Han BH, Yoo SY, Park MH, Lee HJ. Antioxidant activity screening on crude drugs. J Pharmacogn. 1981 ; 12 :66.
  128. Kim KS, Lee CH, Cho JH, Jang JB, Lee KS. A review of the Literature on single herb for treatment of colporrhea. J Orient Gynecol. 2005 ; 18(4) : 153-64.
  129. Ko ST. Diuretic Action of Alismae Water Extract in the Dog. J Cho-Seon Univ. 1975 ; 1975 : 511-21.
  130. Chen DQ, Feng YL, Tian T, Chen H, Yin L, Zhao YY, Lin RC. Diuretic and anti-diuretic activities of fractions of Alismatis rhizoma. J Ethnopharmacol. 2014 ; 157 : 114-8. https://doi.org/10.1016/j.jep.2014.09.022
  131. Feng YL, Chen H, Tian T, Chen DQ, Zhao YY, Lin RC. Diuretic and anti-diuretic activities of the ethanol and aqueous extracts of Alismatis rhizoma. J Ethnopharmacol. 2014 ; 154(2) : 386-90. https://doi.org/10.1016/j.jep.2014.04.017
  132. Lim HJ. Effects of alisma orientale S. and Zea mays L. extracts on the water uptake in the intact frog. Chungnam national university Graduate School. 1983.
  133. Ko ST. On the Diuretic Action of Alismae Rhizoma = Study on the Development of Drugs from Natural Resources(Ⅰ). J Health Schol Assoc. 1975 ; 4 : 1-7.
  134. Choi HI. Study on the diuretic action of three indigenous crude drugs euphorbia sieboldiana hara plantaginis semen and alismatis rhizoma. Kor J Vet Med Association. 1962 ; 6(3) : 1-13.
  135. Roh HS, Seok JH, Jeong JY, Lee JK, Kim TS, Choi HK, Ha HY. Repeated Dose Oral Toxicity Study of Alismatis Rhizoma in SD Rats. J Korean Orient Ophthalmol Otorhinolaryngol Dermatol. 2014 ; 27(1) : 79-90. https://doi.org/10.6114/jkood.2014.27.1.079
  136. Satoh K, Yasuda I, Nagai F, Ushiyama K, Akiyama K, Kano I. The effects of crude drugs using diuretic on horse kidney (Na+ + K+) - adenosine triphosphatase. Yakugaku Zasshi. 1991 ; 111(2) : 138-45. https://doi.org/10.1248/yakushi1947.111.2_138
  137. Huang MQ, Xu W, Wu SS, Lu JJ, Chen XP. A 90-day subchronic oral toxicity study of triterpene-enriched extract from Alismatis Rhizoma in rats. Food Chem Toxicol. 2013 ; 58 : 318-23. https://doi.org/10.1016/j.fct.2013.05.009
  138. Yu Y, Ma C, Bi K, Yang G, Xie P, Wang J, Chen XH. A metabonomic analysis of urine from rats treated with rhizoma alismatis using ultra-performance liquid chromatography/mass spectrometry. Rapid Commun Mass Spectrom. 2011 ; 25(18) : 2633-40. https://doi.org/10.1002/rcm.5163
  139. Park JH, Seo BI. A philological study on poisoning and side effects of Alismatis Rhizoma. JJeajoong Orient Med Assoc. 2012 ; 10(1) : 147-56.
  140. Wang CF, Cheng XD, Gu JF, Yuan JR, Zhao BJ, Zhang L, Chen J, Feng L, Jia XB. Research development of the chemical material basis of Alisma orientalis and its toxicity. Zhongguo Zhong Yao Za Zhi. 2015 ; 40(5) : 840-6.
  141. Kubo M, Matsuda H, Tomohiro N, Yoshikawa M. Studies on Alismatis rhizoma. I. Anti-allergic effects of methanol extract and six terpene components from Alismatis rhizoma (dried rhizome of Alisma orientale). Biol Pharm Bull. 1997 ; 20(5) : 511-6. https://doi.org/10.1248/bpb.20.511
  142. Matsuda H, Tomohiro N, Yoshikawa M, Kubo M. Studies on Alismatis Rhizoma. II. Anti-complementary activities of methanol extract and terpene components from Alismatis Rhizoma (dried rhizome of Alisma orientale). Biol Pharm Bull. 1998 ; 21(12) : 1317-21. https://doi.org/10.1248/bpb.21.1317
  143. Fu QL, Hu YY, Feng Q, Wang XN, Peng JH, Cui T. Analysis of major herbs in Chinese herbal formula Jianpi Huoxue Decoction for improving intestinal permeability based on uniform design. Zhong Xi Yi Jie He Xue Bao. 2011 ; 9(11) : 1234-41. https://doi.org/10.3736/jcim20111112
  144. Dai Y, Hang B, Huang Z, Li P. Anti-inflammatory activities and effect of rhizoma Alismatis on immune system. Zhongguo Zhong Yao Za Zhi. 1991 ; 16(10) : 622-5.
  145. Lee JM, Lee BR. The Experimental Study about Antioxidant Activities of Alismatis Rhizoma Herbal Acupuncutre. J Korean Acu Mox Med Soc. 2003 ; 20(1) : 159-76.
  146. Kim KH, Kwun MJ, Choi JY, Ahn KS, Oh SR, Lee YG, Christman JW, Sadikot RT, Han CW, Joo M. Therapeutic Effect of the Tuber of Alisma orientale on Lipopolysaccharide-Induced Acute Lung Injury. Evid Based Complement Alternat Med. 2013 ; 2013 : 863892.
  147. World Health Organization. WHO International Standard Terminologies on Traditional Medicine in the Western Pacific Region. Manila : WHO Regional Office for the Western Pacific. 2007 : 45, 98, 100, 127, 166, 170, 171.
  148. Oriental Medicine Dictionary Compilation Committee. The Oriental Medicine Dictionary. Seoul : Jungdam Publishing. 2010 : 359, 628, 816, 839, 1100, 1563-4, 1842.
  149. Medline Plus. Kidney Failure. National Institutes of Health Retrieved Jan. 1, 2013, Avaliable from : https://www.nlm.nih.gov/medlineplus/kidneyfailure.html
  150. The Korean Society of Pathologists. Pathology. Seoul : Komoonsa Publishing. 2010 : 694, 787.
  151. Choi YC. Lipid, blood pressure, glucose, and health behavior of normal group and obese group. Daegu haany university Graduate School. 2000.
  152. Sin MG. JeongHwa Imsang Bonchohak. Seoul : Young-Lim Press. 2015 : 679.
  153. State Administration of Traditional chinese medicine of the People's Republic of China. Chinese Herbal Medicine 8. Shanghai : Shanghai Scientific and Technical Publishers. 1999 : 3-4.
  154. Herbal Formula Science Editorial Committee of Korean Medicine schools. Bangjae-hak. Seoul : Young-Lim Press. 2006 : 298, 504.
  155. Lee JH. HanBangJinRyoYohBang. Seoul : Eui-Bang. 2004 : 217.